건성안에서 굴절교정술 여부가 점안제의 임상적 효능에 미치는 영향

Purpose
In this study, the effects of eye drops with different compositions on tear film stability and subjective symptoms in dry eye were examined based on refractive surgery status.

Methods
Solution A and an ophthalmic gel were instilled in dry eye patients with (26 eyes) and without (29 eyes) refractive surgery, and non-invasive tear break-up time (NIBUT), initial break-up location, subjective symptoms and near work discomfort were evaluated and compared with saline.

Results
In the non-refractive surgery group, solution A and the gel increased NIBUT over saline, lasting 30 minutes. In the refractive surgery group, the gel increased NIBUT by 25.0% for 30 minutes. In the non-refractive group, saline and the gel caused localized break-up, whereas solution A exerted even break-up in the inferior (54.9%) and central (27.4%) areas. In the refractive surgery group, the gel produced even break-up in the inferior (60%) and central (26%) areas. Solution A improved gritty and blurred vision in the non-refractive group, and all drops improved poor vision. In the refractive group, all eye drops reduced glare, but the gel increased blurred vision. Near-work discomfort decreased with saline in the non-refractive group and with all drops in the refractive group.

Conclusions
This study confirmed that eye drop effects differed according to refractive surgery status. Therefore, we suggest considering surgery status when selecting dry eye treatment.