공중합체에 따른 약물 콘택트렌즈의 약물 전달 연구

In this study, poly (vinyl pyrrolidone) (PVP), poly (N-isopropylacrylamide) (PNIPAAm) and 3-(trimethoxysilyl) propyl methacrylate (TRIM) were copolymerized with hydroxyethyl methacrylate (HEMA). The effect of pH change on the drug delivery from the polymerized hydrogel lenses was analyzed. Contact lenses were thermally polymerized by varying the ratio of HEMA to PVP, PNIPAAm, and TRIM. Hydroxypropyl methylcellulose (HPMC), a source of artificial tear eye drops was used as a test drug. Drug releasing pattern was analyzed using a UV-spectrophotometer. As a result, the accumulated amount of the drug was gradually increased when the pH was increased in the anionic hydrogel (p-HEMA, p-HEMA-VP) lens. The released drug amount from cationic hydrogel (p-HEMA-NIPAAm) lens was decreased in increased pH. On the other hand, the silicone lens exhibited a drug release pattern opposite to that of the hydrogel lens due to the polymerization of the silicone functional group (-TRIM). This suggests that selective drug delivery from contact lens design is possible through solution-material ionization relationship depending on the polymerization components.