A benzyl carbazate-based fluorescent chemosensor for detecting Zn2+: Application to zebrafish

Sehoon Kim; Hangyul Lee; Haeri So; Hyojin Lee; Ki Tae Kim; Cheal Kim

doi:10.1016/j.saa.2019.117787

A benzyl carbazate-based fluorescent chemosensor for detecting Zn²⁺: Application to zebrafish

Sehoon Kim, Hangyul Lee, Haeri So, Hyojin Lee, Ki Tae Kim, Cheal Kim

Seoul National University of Science and Technology (SNUST)

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

A benzyl carbazate-based fluorescent chemosensor BCS was designed and synthesized for detection of Zn²⁺ in aqueous media. BCS displayed a notable fluorescence increase with Zn²⁺. Detection limit (1.12 μM) of BCS for zinc ion was much lower than the standard of World Health Organization. BCS was used to analyze the amounts of Zn²⁺ in water samples. Importantly, sensor BCS could be used to image Zn²⁺ in zebrafish, and a fluorescent test strip of sensor BCS for detecting Zn²⁺ could be useful for practical purpose. Sensing process of Zn²⁺ by BCS was demonstrated by DFT calculations, based on an effect of chelation-enhanced fluorescence.

Original language	English
Article number	117787
Journal	Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Volume	228
DOIs	https://doi.org/10.1016/j.saa.2019.117787
State	Published - 5 Mar 2020

Keywords

Benzyl carbazate
DFT calculation
Fluorescent chemosensor
Test strip
Zebrafish
Zinc ion

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10.1016/j.saa.2019.117787

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title = "A benzyl carbazate-based fluorescent chemosensor for detecting Zn2+: Application to zebrafish",

abstract = "A benzyl carbazate-based fluorescent chemosensor BCS was designed and synthesized for detection of Zn2+ in aqueous media. BCS displayed a notable fluorescence increase with Zn2+. Detection limit (1.12 μM) of BCS for zinc ion was much lower than the standard of World Health Organization. BCS was used to analyze the amounts of Zn2+ in water samples. Importantly, sensor BCS could be used to image Zn2+ in zebrafish, and a fluorescent test strip of sensor BCS for detecting Zn2+ could be useful for practical purpose. Sensing process of Zn2+ by BCS was demonstrated by DFT calculations, based on an effect of chelation-enhanced fluorescence.",

keywords = "Benzyl carbazate, DFT calculation, Fluorescent chemosensor, Test strip, Zebrafish, Zinc ion",

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T1 - A benzyl carbazate-based fluorescent chemosensor for detecting Zn2+

T2 - Application to zebrafish

AU - Kim, Sehoon

AU - Lee, Hangyul

AU - So, Haeri

AU - Lee, Hyojin

AU - Kim, Ki Tae

AU - Kim, Cheal

PY - 2020/3/5

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AB - A benzyl carbazate-based fluorescent chemosensor BCS was designed and synthesized for detection of Zn2+ in aqueous media. BCS displayed a notable fluorescence increase with Zn2+. Detection limit (1.12 μM) of BCS for zinc ion was much lower than the standard of World Health Organization. BCS was used to analyze the amounts of Zn2+ in water samples. Importantly, sensor BCS could be used to image Zn2+ in zebrafish, and a fluorescent test strip of sensor BCS for detecting Zn2+ could be useful for practical purpose. Sensing process of Zn2+ by BCS was demonstrated by DFT calculations, based on an effect of chelation-enhanced fluorescence.

KW - Benzyl carbazate

KW - DFT calculation

KW - Fluorescent chemosensor

KW - Test strip

KW - Zebrafish

KW - Zinc ion

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A benzyl carbazate-based fluorescent chemosensor for detecting Zn²⁺: Application to zebrafish

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Keywords

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