A highly selective and sensitive fluorescent turn-on Al3+ chemosensor in aqueous media and living cells: Experimental and theoretical studies

In Hong Hwang; Ye Won Choi; Kyung Beom Kim; Gyeong Jin Park; Jae Jun Lee; Le Tuyen Nguyen; Insup Noh; Cheal Kim

doi:10.1039/c5nj02334c

A highly selective and sensitive fluorescent turn-on Al³⁺ chemosensor in aqueous media and living cells: Experimental and theoretical studies

In Hong Hwang, Ye Won Choi, Kyung Beom Kim, Gyeong Jin Park, Jae Jun Lee, Le Tuyen Nguyen, Insup Noh, Cheal Kim

Seoul National University of Science and Technology (SNUST)

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

A highly selective and sensitive fluorescent chemosensor (1) based on a 2-aminobenzoic acid Schiff base has been synthesized in one step. The binding properties of 1 with metal ions were investigated by fluorescence, UV-vis, ¹H NMR and electrospray ionization mass spectra. This sensor exhibited enhanced fluorescence in the presence of Al³⁺ in aqueous solution and also in living cells. The sensing mechanism of 1 toward Al³⁺ was explained by DFT/TDDFT calculations. The binding constant was determined to be 3.1 × 10⁸ M^-1 which is one of the highest binding affinities among such simple Schiff bases for Al³⁺ in buffer solution. The calibration curve for the analytical performance of Al³⁺ was found to be linear over a concentration range with a very low detection limit of 290 nM (3σ).

Original language	English
Pages (from-to)	171-178
Number of pages	8
Journal	New Journal of Chemistry
Volume	40
Issue number	1
DOIs	https://doi.org/10.1039/c5nj02334c
State	Published - 1 Jan 2016

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title = "A highly selective and sensitive fluorescent turn-on Al3+ chemosensor in aqueous media and living cells: Experimental and theoretical studies",

abstract = "A highly selective and sensitive fluorescent chemosensor (1) based on a 2-aminobenzoic acid Schiff base has been synthesized in one step. The binding properties of 1 with metal ions were investigated by fluorescence, UV-vis, 1H NMR and electrospray ionization mass spectra. This sensor exhibited enhanced fluorescence in the presence of Al3+ in aqueous solution and also in living cells. The sensing mechanism of 1 toward Al3+ was explained by DFT/TDDFT calculations. The binding constant was determined to be 3.1 × 108 M-1 which is one of the highest binding affinities among such simple Schiff bases for Al3+ in buffer solution. The calibration curve for the analytical performance of Al3+ was found to be linear over a concentration range with a very low detection limit of 290 nM (3σ).",

author = "Hwang, \{In Hong\} and Choi, \{Ye Won\} and Kim, \{Kyung Beom\} and Park, \{Gyeong Jin\} and Lee, \{Jae Jun\} and Nguyen, \{Le Tuyen\} and Insup Noh and Cheal Kim",

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doi = "10.1039/c5nj02334c",

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AU - Hwang, In Hong

AU - Choi, Ye Won

AU - Kim, Kyung Beom

AU - Park, Gyeong Jin

AU - Lee, Jae Jun

AU - Nguyen, Le Tuyen

AU - Noh, Insup

AU - Kim, Cheal

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AB - A highly selective and sensitive fluorescent chemosensor (1) based on a 2-aminobenzoic acid Schiff base has been synthesized in one step. The binding properties of 1 with metal ions were investigated by fluorescence, UV-vis, 1H NMR and electrospray ionization mass spectra. This sensor exhibited enhanced fluorescence in the presence of Al3+ in aqueous solution and also in living cells. The sensing mechanism of 1 toward Al3+ was explained by DFT/TDDFT calculations. The binding constant was determined to be 3.1 × 108 M-1 which is one of the highest binding affinities among such simple Schiff bases for Al3+ in buffer solution. The calibration curve for the analytical performance of Al3+ was found to be linear over a concentration range with a very low detection limit of 290 nM (3σ).

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A highly selective and sensitive fluorescent turn-on Al³⁺ chemosensor in aqueous media and living cells: Experimental and theoretical studies

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