A highly selective CHEF-type chemosensor for monitoring Zn2+ in aqueous solution and living cells

Jae Jun Lee; Seul Ah Lee; Hyun Kim; Letuyen Nguyen; Insup Noh; Cheal Kim

doi:10.1039/c5ra05080d

A highly selective CHEF-type chemosensor for monitoring Zn²⁺ in aqueous solution and living cells

Jae Jun Lee, Seul Ah Lee, Hyun Kim, Letuyen Nguyen, Insup Noh, Cheal Kim

Seoul National University of Science and Technology (SNUST)

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

A new simple quinolone-based chemosensor 1 was synthesized for Zn²⁺. 1 exhibited selective fluorescence enhancement in the presence of Zn²⁺ with a 1:1 stoichiometry in aqueous solution, which was reversible with the addition of ethylenediaminetetraacetic acid (EDTA). The detection limit (0.019 μM) of 1 for Zn²⁺ is far lower than the World Health Organization guideline (76 μM) in drinking water. 1 was successfully applied to quantify and image Zn²⁺ in water samples and living cells. The sensing mechanism of Zn²⁺ by 1via the chelation-enhanced fluorescence (CHEF) effect was supported by theoretical calculations. Therefore, 1 could be used in a practical system for monitoring Zn²⁺ in aqueous solution.

Original language	English
Pages (from-to)	41905-41913
Number of pages	9
Journal	RSC Advances
Volume	5
Issue number	52
DOIs	https://doi.org/10.1039/c5ra05080d
State	Published - 2015

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title = "A highly selective CHEF-type chemosensor for monitoring Zn2+ in aqueous solution and living cells",

abstract = "A new simple quinolone-based chemosensor 1 was synthesized for Zn2+. 1 exhibited selective fluorescence enhancement in the presence of Zn2+ with a 1:1 stoichiometry in aqueous solution, which was reversible with the addition of ethylenediaminetetraacetic acid (EDTA). The detection limit (0.019 μM) of 1 for Zn2+ is far lower than the World Health Organization guideline (76 μM) in drinking water. 1 was successfully applied to quantify and image Zn2+ in water samples and living cells. The sensing mechanism of Zn2+ by 1via the chelation-enhanced fluorescence (CHEF) effect was supported by theoretical calculations. Therefore, 1 could be used in a practical system for monitoring Zn2+ in aqueous solution.",

author = "Lee, \{Jae Jun\} and Lee, \{Seul Ah\} and Hyun Kim and Letuyen Nguyen and Insup Noh and Cheal Kim",

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doi = "10.1039/c5ra05080d",

language = "English",

volume = "5",

pages = "41905--41913",

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T1 - A highly selective CHEF-type chemosensor for monitoring Zn2+ in aqueous solution and living cells

AU - Lee, Jae Jun

AU - Lee, Seul Ah

AU - Kim, Hyun

AU - Nguyen, Letuyen

AU - Noh, Insup

AU - Kim, Cheal

PY - 2015

Y1 - 2015

N2 - A new simple quinolone-based chemosensor 1 was synthesized for Zn2+. 1 exhibited selective fluorescence enhancement in the presence of Zn2+ with a 1:1 stoichiometry in aqueous solution, which was reversible with the addition of ethylenediaminetetraacetic acid (EDTA). The detection limit (0.019 μM) of 1 for Zn2+ is far lower than the World Health Organization guideline (76 μM) in drinking water. 1 was successfully applied to quantify and image Zn2+ in water samples and living cells. The sensing mechanism of Zn2+ by 1via the chelation-enhanced fluorescence (CHEF) effect was supported by theoretical calculations. Therefore, 1 could be used in a practical system for monitoring Zn2+ in aqueous solution.

AB - A new simple quinolone-based chemosensor 1 was synthesized for Zn2+. 1 exhibited selective fluorescence enhancement in the presence of Zn2+ with a 1:1 stoichiometry in aqueous solution, which was reversible with the addition of ethylenediaminetetraacetic acid (EDTA). The detection limit (0.019 μM) of 1 for Zn2+ is far lower than the World Health Organization guideline (76 μM) in drinking water. 1 was successfully applied to quantify and image Zn2+ in water samples and living cells. The sensing mechanism of Zn2+ by 1via the chelation-enhanced fluorescence (CHEF) effect was supported by theoretical calculations. Therefore, 1 could be used in a practical system for monitoring Zn2+ in aqueous solution.

UR - https://www.scopus.com/pages/publications/84929379326

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DO - 10.1039/c5ra05080d

M3 - Article

AN - SCOPUS:84929379326

SN - 2046-2069

VL - 5

SP - 41905

EP - 41913

JO - RSC Advances

JF - RSC Advances

IS - 52

ER -

A highly selective CHEF-type chemosensor for monitoring Zn²⁺ in aqueous solution and living cells

Abstract

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