A highly selective turn-on chemosensor capable of monitoring Zn2+ concentrations in living cells and aqueous solution

Gyeong Jin Park; Hyun Kim; Jae Jun Lee; Yong Sung Kim; Sun Young Lee; Suyeon Lee; Insup Noh; Cheal Kim

doi:10.1016/j.snb.2015.03.108

A highly selective turn-on chemosensor capable of monitoring Zn²⁺ concentrations in living cells and aqueous solution

Gyeong Jin Park, Hyun Kim, Jae Jun Lee, Yong Sung Kim, Sun Young Lee, Suyeon Lee, Insup Noh, Cheal Kim

Seoul National University of Science and Technology (SNUST)

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

A new simple "off-on fluorescence type" chemosensor 1 (2-(N-(2-hydroxyethyl)-N-((pyridin-2-yl)methyl)amino)-N-(quinolin-8-yl)acetamide) has been synthesized for Zn²⁺. The sensor 1 comprises of the quinoline as fluorophore and the 2-((pyridin-2-yl)methylamino)ethanol as both binding site and water-soluble functional group. 1 showed a remarkable fluorescence enhancement in the presence of Zn²⁺ in aqueous solution, which was reversible with the addition of ethylenediaminetetraacetic acid (EDTA). The detection limit (0.02 μM) of 1 for Zn²⁺ is far lower than World Health Organization guideline (76 μM) in drinking water. Importantly, the chemosensor 1 could be used to detect and quantify Zn²⁺ in living cells and water samples. Moreover, the sensing mechanism was supported by theoretical calculations. Therefore, this sensor has the ability to be a practical system for monitoring Zn²⁺ concentrations in biological and aqueous samples.

Original language	English
Pages (from-to)	568-576
Number of pages	9
Journal	Sensors and Actuators, B: Chemical
Volume	215
DOIs	https://doi.org/10.1016/j.snb.2015.03.108
State	Published - 1 Aug 2015

Keywords

Cell imaging
CHEF
Chemosensor
Determination of Zn ion
Fluorescence

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.snb.2015.03.108

Cite this

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title = "A highly selective turn-on chemosensor capable of monitoring Zn2+ concentrations in living cells and aqueous solution",

abstract = "A new simple {"}off-on fluorescence type{"} chemosensor 1 (2-(N-(2-hydroxyethyl)-N-((pyridin-2-yl)methyl)amino)-N-(quinolin-8-yl)acetamide) has been synthesized for Zn2+. The sensor 1 comprises of the quinoline as fluorophore and the 2-((pyridin-2-yl)methylamino)ethanol as both binding site and water-soluble functional group. 1 showed a remarkable fluorescence enhancement in the presence of Zn2+ in aqueous solution, which was reversible with the addition of ethylenediaminetetraacetic acid (EDTA). The detection limit (0.02 μM) of 1 for Zn2+ is far lower than World Health Organization guideline (76 μM) in drinking water. Importantly, the chemosensor 1 could be used to detect and quantify Zn2+ in living cells and water samples. Moreover, the sensing mechanism was supported by theoretical calculations. Therefore, this sensor has the ability to be a practical system for monitoring Zn2+ concentrations in biological and aqueous samples.",

keywords = "Cell imaging, CHEF, Chemosensor, Determination of Zn ion, Fluorescence",

author = "Park, \{Gyeong Jin\} and Hyun Kim and Lee, \{Jae Jun\} and Kim, \{Yong Sung\} and Lee, \{Sun Young\} and Suyeon Lee and Insup Noh and Cheal Kim",

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doi = "10.1016/j.snb.2015.03.108",

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AU - Park, Gyeong Jin

AU - Kim, Hyun

AU - Lee, Jae Jun

AU - Kim, Yong Sung

AU - Lee, Sun Young

AU - Lee, Suyeon

AU - Noh, Insup

AU - Kim, Cheal

PY - 2015/8/1

Y1 - 2015/8/1

N2 - A new simple "off-on fluorescence type" chemosensor 1 (2-(N-(2-hydroxyethyl)-N-((pyridin-2-yl)methyl)amino)-N-(quinolin-8-yl)acetamide) has been synthesized for Zn2+. The sensor 1 comprises of the quinoline as fluorophore and the 2-((pyridin-2-yl)methylamino)ethanol as both binding site and water-soluble functional group. 1 showed a remarkable fluorescence enhancement in the presence of Zn2+ in aqueous solution, which was reversible with the addition of ethylenediaminetetraacetic acid (EDTA). The detection limit (0.02 μM) of 1 for Zn2+ is far lower than World Health Organization guideline (76 μM) in drinking water. Importantly, the chemosensor 1 could be used to detect and quantify Zn2+ in living cells and water samples. Moreover, the sensing mechanism was supported by theoretical calculations. Therefore, this sensor has the ability to be a practical system for monitoring Zn2+ concentrations in biological and aqueous samples.

AB - A new simple "off-on fluorescence type" chemosensor 1 (2-(N-(2-hydroxyethyl)-N-((pyridin-2-yl)methyl)amino)-N-(quinolin-8-yl)acetamide) has been synthesized for Zn2+. The sensor 1 comprises of the quinoline as fluorophore and the 2-((pyridin-2-yl)methylamino)ethanol as both binding site and water-soluble functional group. 1 showed a remarkable fluorescence enhancement in the presence of Zn2+ in aqueous solution, which was reversible with the addition of ethylenediaminetetraacetic acid (EDTA). The detection limit (0.02 μM) of 1 for Zn2+ is far lower than World Health Organization guideline (76 μM) in drinking water. Importantly, the chemosensor 1 could be used to detect and quantify Zn2+ in living cells and water samples. Moreover, the sensing mechanism was supported by theoretical calculations. Therefore, this sensor has the ability to be a practical system for monitoring Zn2+ concentrations in biological and aqueous samples.

KW - Cell imaging

KW - CHEF

KW - Chemosensor

KW - Determination of Zn ion

KW - Fluorescence

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