A highly selective turn-on chemosensor for Zn2+ in aqueous media and living cells

Jae Min Jung; Seong Youl Lee; Eunju Nam; Mi Hee Lim; Cheal Kim

doi:10.1016/j.snb.2017.01.076

A highly selective turn-on chemosensor for Zn²⁺ in aqueous media and living cells

Jae Min Jung, Seong Youl Lee, Eunju Nam, Mi Hee Lim, Cheal Kim

Dept. of Fine Chemistry

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

A new simple quinoline-based chemosensor 1 was synthesized for Zn²⁺. 1 showed the selective fluorescence enhancement in the presence of Zn²⁺with a 1:1 stoichiometry in a near-perfect aqueous solution (bis-tris buffer:DMSO = 999:1), which was reversible with the addition of ethylenediaminetetraacetic acid (EDTA). The detection limit (0.6 μM) of 1 for Zn²⁺was much lower than World Health Organization guideline (76 μM) in drinking water. 1 was successfully applied to quantify and image Zn²⁺in water samples, test kit and living cells. The sensing mechanism of Zn²⁺by 1 via the intramolecular charge transfer was explained by theoretical calculations.

Original language	English
Pages (from-to)	1045-1053
Number of pages	9
Journal	Sensors and Actuators, B: Chemical
Volume	244
DOIs	https://doi.org/10.1016/j.snb.2017.01.076
State	Published - 2017

Keywords

Cell imaging
Fluorescent chemosensor
Test kit
Theoretical calculations
Zinc ion

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.snb.2017.01.076

Cite this

@article{82eb6b978ef94199ac39c43b76e66ea5,

title = "A highly selective turn-on chemosensor for Zn2+ in aqueous media and living cells",

abstract = "A new simple quinoline-based chemosensor 1 was synthesized for Zn2+. 1 showed the selective fluorescence enhancement in the presence of Zn2+with a 1:1 stoichiometry in a near-perfect aqueous solution (bis-tris buffer:DMSO = 999:1), which was reversible with the addition of ethylenediaminetetraacetic acid (EDTA). The detection limit (0.6 μM) of 1 for Zn2+was much lower than World Health Organization guideline (76 μM) in drinking water. 1 was successfully applied to quantify and image Zn2+in water samples, test kit and living cells. The sensing mechanism of Zn2+by 1 via the intramolecular charge transfer was explained by theoretical calculations.",

keywords = "Cell imaging, Fluorescent chemosensor, Test kit, Theoretical calculations, Zinc ion",

author = "Jung, \{Jae Min\} and Lee, \{Seong Youl\} and Eunju Nam and Lim, \{Mi Hee\} and Cheal Kim",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",

year = "2017",

doi = "10.1016/j.snb.2017.01.076",

language = "English",

volume = "244",

pages = "1045--1053",

journal = "Sensors and Actuators, B: Chemical",

issn = "0925-4005",

}

TY - JOUR

T1 - A highly selective turn-on chemosensor for Zn2+ in aqueous media and living cells

AU - Jung, Jae Min

AU - Lee, Seong Youl

AU - Nam, Eunju

AU - Lim, Mi Hee

AU - Kim, Cheal

PY - 2017

Y1 - 2017

N2 - A new simple quinoline-based chemosensor 1 was synthesized for Zn2+. 1 showed the selective fluorescence enhancement in the presence of Zn2+with a 1:1 stoichiometry in a near-perfect aqueous solution (bis-tris buffer:DMSO = 999:1), which was reversible with the addition of ethylenediaminetetraacetic acid (EDTA). The detection limit (0.6 μM) of 1 for Zn2+was much lower than World Health Organization guideline (76 μM) in drinking water. 1 was successfully applied to quantify and image Zn2+in water samples, test kit and living cells. The sensing mechanism of Zn2+by 1 via the intramolecular charge transfer was explained by theoretical calculations.

AB - A new simple quinoline-based chemosensor 1 was synthesized for Zn2+. 1 showed the selective fluorescence enhancement in the presence of Zn2+with a 1:1 stoichiometry in a near-perfect aqueous solution (bis-tris buffer:DMSO = 999:1), which was reversible with the addition of ethylenediaminetetraacetic acid (EDTA). The detection limit (0.6 μM) of 1 for Zn2+was much lower than World Health Organization guideline (76 μM) in drinking water. 1 was successfully applied to quantify and image Zn2+in water samples, test kit and living cells. The sensing mechanism of Zn2+by 1 via the intramolecular charge transfer was explained by theoretical calculations.

KW - Cell imaging

KW - Fluorescent chemosensor

KW - Test kit

KW - Theoretical calculations

KW - Zinc ion

UR - http://www.scopus.com/inward/record.url?scp=85010213678&partnerID=8YFLogxK

U2 - 10.1016/j.snb.2017.01.076

DO - 10.1016/j.snb.2017.01.076

M3 - Article

AN - SCOPUS:85010213678

SN - 0925-4005

VL - 244

SP - 1045

EP - 1053

JO - Sensors and Actuators, B: Chemical

JF - Sensors and Actuators, B: Chemical

ER -