A method for the synthesis of pyridines from aldehydes, alkynes and NH4OAc involving Rh-catalyzed hydroacylation andN-annulation

Yong Kyun Sim; Hyejeong Lee; Jung Woo Park; Dong Su Kim; Chul Ho Jun

doi:10.1039/c2cc36956g

A method for the synthesis of pyridines from aldehydes, alkynes and NH₄OAc involving Rh-catalyzed hydroacylation andN-annulation

Yong Kyun Sim, Hyejeong Lee, Jung Woo Park, Dong Su Kim, Chul Ho Jun

Dept. of Fine Chemistry

Yonsei University

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

A new method for regiocontrolled pyridine synthesis has been developed involving sequential Rh(i)-catalyzed chelation-assisted hydroacylation of alkynes with aldehydes followed by Rh(iii)-promotedN-annulation of the resulting α,β-enones with another alkyne and NH₃.

Original language	English
Pages (from-to)	11787-11789
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	96
DOIs	https://doi.org/10.1039/c2cc36956g
State	Published - 7 Nov 2012

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title = "A method for the synthesis of pyridines from aldehydes, alkynes and NH4OAc involving Rh-catalyzed hydroacylation andN-annulation",

abstract = "A new method for regiocontrolled pyridine synthesis has been developed involving sequential Rh(i)-catalyzed chelation-assisted hydroacylation of alkynes with aldehydes followed by Rh(iii)-promotedN-annulation of the resulting α,β-enones with another alkyne and NH3.",

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T1 - A method for the synthesis of pyridines from aldehydes, alkynes and NH4OAc involving Rh-catalyzed hydroacylation andN-annulation

AU - Sim, Yong Kyun

AU - Lee, Hyejeong

AU - Park, Jung Woo

AU - Kim, Dong Su

AU - Jun, Chul Ho

PY - 2012/11/7

Y1 - 2012/11/7

N2 - A new method for regiocontrolled pyridine synthesis has been developed involving sequential Rh(i)-catalyzed chelation-assisted hydroacylation of alkynes with aldehydes followed by Rh(iii)-promotedN-annulation of the resulting α,β-enones with another alkyne and NH3.

AB - A new method for regiocontrolled pyridine synthesis has been developed involving sequential Rh(i)-catalyzed chelation-assisted hydroacylation of alkynes with aldehydes followed by Rh(iii)-promotedN-annulation of the resulting α,β-enones with another alkyne and NH3.

UR - https://www.scopus.com/pages/publications/84868539417

U2 - 10.1039/c2cc36956g

DO - 10.1039/c2cc36956g

M3 - Article

AN - SCOPUS:84868539417

SN - 1359-7345

VL - 48

SP - 11787

EP - 11789

JO - Chemical Communications

JF - Chemical Communications

IS - 96

ER -

A method for the synthesis of pyridines from aldehydes, alkynes and NH₄OAc involving Rh-catalyzed hydroacylation andN-annulation

Abstract

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