A novel “off-on” type fluorescent chemosensor for detection of Zn2+ and its zinc complex for “on-off” fluorescent sensing of sulfide in aqueous solution, in vitro and in vivo

Jae Min Jung; Ji Hye Kang; Jiyeon Han; Hyojin Lee; Mi Hee Lim; Ki Tae Kim; Cheal Kim

doi:10.1016/j.snb.2018.03.063

A novel “off-on” type fluorescent chemosensor for detection of Zn²⁺ and its zinc complex for “on-off” fluorescent sensing of sulfide in aqueous solution, in vitro and in vivo

Jae Min Jung
, Ji Hye Kang
, Jiyeon Han
, Hyojin Lee
, Mi Hee Lim
, Ki Tae Kim
, Cheal Kim

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

We reported a new quinoline-based fluorescent probe 1 for Zn²⁺ and S²⁻. 1 showed a highly selective fluorescence enhancement toward Zn²⁺ over other metal ions including Cd²⁺, and the resulting 1-Zn²⁺ complex could detect only S²⁻ among the various anions. The detection limits (0.09 μM and 0.88 μM) for Zn²⁺ and S²⁻ were much lower than recommended values (76 μM for Zn²⁺ and 14.8 μM for S²⁻) by WHO. Their recognition mechanisms were explained by Job plots, UV–vis titrations, ¹H NMR titrations, ESI-mass, and theoretical calculations. Moreover, compound 1 with the great photostability and low biotoxicity showed sequentially off-on-off fluorescent bio-imaging of Zn²⁺ and S²⁻ in both HeLa cells and live zebrafish larvae.

Original language	English
Pages (from-to)	58-69
Number of pages	12
Journal	Sensors and Actuators, B: Chemical
Volume	267
DOIs	https://doi.org/10.1016/j.snb.2018.03.063
State	Published - 15 Aug 2018

Keywords

Cell and zebrafish imaging
Fluorescent chemosensor
Sulfide
Theoretical calculations
Zinc ion

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10.1016/j.snb.2018.03.063

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title = "A novel “off-on” type fluorescent chemosensor for detection of Zn2+ and its zinc complex for “on-off” fluorescent sensing of sulfide in aqueous solution, in vitro and in vivo",

abstract = "We reported a new quinoline-based fluorescent probe 1 for Zn2+ and S2−. 1 showed a highly selective fluorescence enhancement toward Zn2+ over other metal ions including Cd2+, and the resulting 1-Zn2+ complex could detect only S2− among the various anions. The detection limits (0.09 μM and 0.88 μM) for Zn2+ and S2− were much lower than recommended values (76 μM for Zn2+ and 14.8 μM for S2−) by WHO. Their recognition mechanisms were explained by Job plots, UV–vis titrations, 1H NMR titrations, ESI-mass, and theoretical calculations. Moreover, compound 1 with the great photostability and low biotoxicity showed sequentially off-on-off fluorescent bio-imaging of Zn2+ and S2− in both HeLa cells and live zebrafish larvae.",

keywords = "Cell and zebrafish imaging, Fluorescent chemosensor, Sulfide, Theoretical calculations, Zinc ion",

author = "Jung, \{Jae Min\} and Kang, \{Ji Hye\} and Jiyeon Han and Hyojin Lee and Lim, \{Mi Hee\} and Kim, \{Ki Tae\} and Cheal Kim",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier B.V.",

year = "2018",

month = aug,

day = "15",

doi = "10.1016/j.snb.2018.03.063",

language = "English",

volume = "267",

pages = "58--69",

journal = "Sensors and Actuators, B: Chemical",

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A novel “off-on” type fluorescent chemosensor for detection of Zn²⁺ and its zinc complex for “on-off” fluorescent sensing of sulfide in aqueous solution, in vitro and in vivo. / Jung, Jae Min; Kang, Ji Hye; Han, Jiyeon et al.
In: Sensors and Actuators, B: Chemical, Vol. 267, 15.08.2018, p. 58-69.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - A novel “off-on” type fluorescent chemosensor for detection of Zn2+ and its zinc complex for “on-off” fluorescent sensing of sulfide in aqueous solution, in vitro and in vivo

AU - Jung, Jae Min

AU - Kang, Ji Hye

AU - Han, Jiyeon

AU - Lee, Hyojin

AU - Lim, Mi Hee

AU - Kim, Ki Tae

AU - Kim, Cheal

PY - 2018/8/15

Y1 - 2018/8/15

N2 - We reported a new quinoline-based fluorescent probe 1 for Zn2+ and S2−. 1 showed a highly selective fluorescence enhancement toward Zn2+ over other metal ions including Cd2+, and the resulting 1-Zn2+ complex could detect only S2− among the various anions. The detection limits (0.09 μM and 0.88 μM) for Zn2+ and S2− were much lower than recommended values (76 μM for Zn2+ and 14.8 μM for S2−) by WHO. Their recognition mechanisms were explained by Job plots, UV–vis titrations, 1H NMR titrations, ESI-mass, and theoretical calculations. Moreover, compound 1 with the great photostability and low biotoxicity showed sequentially off-on-off fluorescent bio-imaging of Zn2+ and S2− in both HeLa cells and live zebrafish larvae.

AB - We reported a new quinoline-based fluorescent probe 1 for Zn2+ and S2−. 1 showed a highly selective fluorescence enhancement toward Zn2+ over other metal ions including Cd2+, and the resulting 1-Zn2+ complex could detect only S2− among the various anions. The detection limits (0.09 μM and 0.88 μM) for Zn2+ and S2− were much lower than recommended values (76 μM for Zn2+ and 14.8 μM for S2−) by WHO. Their recognition mechanisms were explained by Job plots, UV–vis titrations, 1H NMR titrations, ESI-mass, and theoretical calculations. Moreover, compound 1 with the great photostability and low biotoxicity showed sequentially off-on-off fluorescent bio-imaging of Zn2+ and S2− in both HeLa cells and live zebrafish larvae.

KW - Cell and zebrafish imaging

KW - Fluorescent chemosensor

KW - Sulfide

KW - Theoretical calculations

KW - Zinc ion

UR - https://www.scopus.com/pages/publications/85045071572

U2 - 10.1016/j.snb.2018.03.063

DO - 10.1016/j.snb.2018.03.063

M3 - Article

AN - SCOPUS:85045071572

SN - 0925-4005

VL - 267

SP - 58

EP - 69

JO - Sensors and Actuators, B: Chemical

JF - Sensors and Actuators, B: Chemical

ER -

A novel “off-on” type fluorescent chemosensor for detection of Zn²⁺ and its zinc complex for “on-off” fluorescent sensing of sulfide in aqueous solution, in vitro and in vivo

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Keywords

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