A Practical Hydrazine-Carbothioamide-Based Fluorescent Probe for the Detection of Zn2+: Applications to Paper Strip, Zebrafish and Water Samples

Boeon Suh; Dongkyun Gil; Sojeong Yoon; Ki Tae Kim; Cheal Kim

doi:10.3390/chemosensors10010032

A Practical Hydrazine-Carbothioamide-Based Fluorescent Probe for the Detection of Zn²⁺: Applications to Paper Strip, Zebrafish and Water Samples

Boeon Suh
, Dongkyun Gil
, Sojeong Yoon
, Ki Tae Kim
, Cheal Kim

Seoul National University of Science and Technology (SNUST)

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

A practical hydrazine-carbothioamide-based fluorescent chemosensor TCC (N-(4-chlorophenyl)-2-(thiophene-2-carbonyl)hydrazine-1-carbothioamide) was applied for Zn²⁺ detection. TCC exhibited selective fluorescence emission for Zn²⁺ and did not show any interference with other metal ions. In particular, TCC was utilized for the detection of Zn²⁺ in paper strips, zebrafish and real water samples. TCC could detect Zn²⁺ down to 0.39 µM in the solution phase and 51.13 µM in zebrafish. The association ratio between TCC and Zn²⁺ was determined to be 2:1 by ESI-mass and Job plot. The sensing mechanism of TCC for Zn²⁺ was illustrated to be a chelation-enhanced fluorescence process through spectroscopic experiments and theoretical calculations.

Original language	English
Article number	32
Journal	Chemosensors
Volume	10
Issue number	1
DOIs	https://doi.org/10.3390/chemosensors10010032
State	Published - Jan 2022

Keywords

Carbothioamide
Chemosensor
Hydrazine
Test-strip
Zebrafish
Zinc ion

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10.3390/chemosensors10010032

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title = "A Practical Hydrazine-Carbothioamide-Based Fluorescent Probe for the Detection of Zn2+: Applications to Paper Strip, Zebrafish and Water Samples",

abstract = "A practical hydrazine-carbothioamide-based fluorescent chemosensor TCC (N-(4-chlorophenyl)-2-(thiophene-2-carbonyl)hydrazine-1-carbothioamide) was applied for Zn2+ detection. TCC exhibited selective fluorescence emission for Zn2+ and did not show any interference with other metal ions. In particular, TCC was utilized for the detection of Zn2+ in paper strips, zebrafish and real water samples. TCC could detect Zn2+ down to 0.39 µM in the solution phase and 51.13 µM in zebrafish. The association ratio between TCC and Zn2+ was determined to be 2:1 by ESI-mass and Job plot. The sensing mechanism of TCC for Zn2+ was illustrated to be a chelation-enhanced fluorescence process through spectroscopic experiments and theoretical calculations.",

keywords = "Carbothioamide, Chemosensor, Hydrazine, Test-strip, Zebrafish, Zinc ion",

author = "Boeon Suh and Dongkyun Gil and Sojeong Yoon and Kim, \{Ki Tae\} and Cheal Kim",

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doi = "10.3390/chemosensors10010032",

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T2 - Applications to Paper Strip, Zebrafish and Water Samples

AU - Suh, Boeon

AU - Gil, Dongkyun

AU - Yoon, Sojeong

AU - Kim, Ki Tae

AU - Kim, Cheal

PY - 2022/1

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AB - A practical hydrazine-carbothioamide-based fluorescent chemosensor TCC (N-(4-chlorophenyl)-2-(thiophene-2-carbonyl)hydrazine-1-carbothioamide) was applied for Zn2+ detection. TCC exhibited selective fluorescence emission for Zn2+ and did not show any interference with other metal ions. In particular, TCC was utilized for the detection of Zn2+ in paper strips, zebrafish and real water samples. TCC could detect Zn2+ down to 0.39 µM in the solution phase and 51.13 µM in zebrafish. The association ratio between TCC and Zn2+ was determined to be 2:1 by ESI-mass and Job plot. The sensing mechanism of TCC for Zn2+ was illustrated to be a chelation-enhanced fluorescence process through spectroscopic experiments and theoretical calculations.

KW - Carbothioamide

KW - Chemosensor

KW - Hydrazine

KW - Test-strip

KW - Zebrafish

KW - Zinc ion

UR - https://www.scopus.com/pages/publications/85123603107

U2 - 10.3390/chemosensors10010032

DO - 10.3390/chemosensors10010032

M3 - Article

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SN - 2227-9040

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ER -

A Practical Hydrazine-Carbothioamide-Based Fluorescent Probe for the Detection of Zn²⁺: Applications to Paper Strip, Zebrafish and Water Samples

Abstract

Keywords

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