TY - JOUR
T1 - A Reconfigurable and Portable Highly Sensitive Biosensor Platform for ISFET and Enzyme-Based Sensors
AU - Lee, Ikho
AU - Lee, Seung Woo
AU - Lee, Ki Young
AU - Park, Chanoh
AU - Kim, Donghoon
AU - Lee, Jeong Soo
AU - Yi, Hyunjung
AU - Kim, Byungsub
N1 - Publisher Copyright:
© 2016 IEEE.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - This paper presents a portable low-cost biosensor platform for ion-sensitive field-effect transistor (ISFET) and enzyme-based sensors. To meet various demands of diagnosis, our portable platform is designed to perform cyclic voltammetry, amperometry, and linear sweep voltammetry for enzyme-based sensor and ISFET sensor. For compatibility with various sensors which require various electrical driving schemes, our system can be easily reconfigured by simple switches. In addition, with disposable printed-circuit-board packages, sensors can be easily replaced. Our platform was tested with various sensors in various measurement methods. In cyclic voltammetry test with a model analyte K3Fe(CN)6, a graph provided by our system has 4.79% relative error at a current peak compared with the data acquired by a 18 times more expensive commercial system. In cyclic voltammetry and amperometry tests with the laccase enzyme-based sensors, our system achieved sensitivities of 341 and 500 μA/mM/cm2, respectively. By running a sensitive SiNW ISFET on our platform in linear sweep voltammetry, we could build a low-cost portable pH sensor system.
AB - This paper presents a portable low-cost biosensor platform for ion-sensitive field-effect transistor (ISFET) and enzyme-based sensors. To meet various demands of diagnosis, our portable platform is designed to perform cyclic voltammetry, amperometry, and linear sweep voltammetry for enzyme-based sensor and ISFET sensor. For compatibility with various sensors which require various electrical driving schemes, our system can be easily reconfigured by simple switches. In addition, with disposable printed-circuit-board packages, sensors can be easily replaced. Our platform was tested with various sensors in various measurement methods. In cyclic voltammetry test with a model analyte K3Fe(CN)6, a graph provided by our system has 4.79% relative error at a current peak compared with the data acquired by a 18 times more expensive commercial system. In cyclic voltammetry and amperometry tests with the laccase enzyme-based sensors, our system achieved sensitivities of 341 and 500 μA/mM/cm2, respectively. By running a sensitive SiNW ISFET on our platform in linear sweep voltammetry, we could build a low-cost portable pH sensor system.
KW - Amperometry
KW - Biosensor platform
KW - Cyclic voltammetry
KW - Enzyme-based catechol sensor
KW - Linear sweep voltammetry
KW - SiNW ISFET
UR - http://www.scopus.com/inward/record.url?scp=84968877301&partnerID=8YFLogxK
U2 - 10.1109/JSEN.2016.2541698
DO - 10.1109/JSEN.2016.2541698
M3 - Article
AN - SCOPUS:84968877301
SN - 1530-437X
VL - 16
SP - 4443
EP - 4451
JO - IEEE Sensors Journal
JF - IEEE Sensors Journal
IS - 11
M1 - 2541698
ER -