A single chemosensor for multiple analytes: Fluorogenic detection of Zn2+ and OAc- ions in aqueous solution, and an application to bioimaging

Gyeong Jin Park; Yu Jeong Na; Hyun Yong Jo; Seul Ah Lee; Ah Ram Kim; Insup Noh; Cheal Kim

doi:10.1039/c4nj00191e

A single chemosensor for multiple analytes: Fluorogenic detection of Zn²⁺ and OAc^- ions in aqueous solution, and an application to bioimaging

Gyeong Jin Park
, Yu Jeong Na
, Hyun Yong Jo
, Seul Ah Lee
, Ah Ram Kim
, Insup Noh
, Cheal Kim

Seoul National University of Science and Technology (SNUST)

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

A new highly selective and sensitive chemosensor 1 for both Zn²⁺ and OAc^- with off-on fluorescence behavior in aqueous solution was developed. The selectivity mechanism of 1 for zinc is based on a combinational effect of the inhibition of excited-state intramolecular proton transfer and CN isomerization, and chelation-enhanced fluorescence. As a practical application, in vitro studies with fibroblasts showed fluorescence in the presence of both the receptor 1 and Zn²⁺. Moreover, the deprotonated 1 can behave as a chemosensing system for turn-on detection of OAc^- in preference over various other anions tested. Therefore, 1 can serve as 'one sensor for multiple analytes'. This journal is

Original language	English
Pages (from-to)	2587-2594
Number of pages	8
Journal	New Journal of Chemistry
Volume	38
Issue number	6
DOIs	https://doi.org/10.1039/c4nj00191e
State	Published - Jun 2014

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abstract = "A new highly selective and sensitive chemosensor 1 for both Zn2+ and OAc- with off-on fluorescence behavior in aqueous solution was developed. The selectivity mechanism of 1 for zinc is based on a combinational effect of the inhibition of excited-state intramolecular proton transfer and CN isomerization, and chelation-enhanced fluorescence. As a practical application, in vitro studies with fibroblasts showed fluorescence in the presence of both the receptor 1 and Zn2+. Moreover, the deprotonated 1 can behave as a chemosensing system for turn-on detection of OAc- in preference over various other anions tested. Therefore, 1 can serve as 'one sensor for multiple analytes'. This journal is",

author = "Park, \{Gyeong Jin\} and Na, \{Yu Jeong\} and Jo, \{Hyun Yong\} and Lee, \{Seul Ah\} and Kim, \{Ah Ram\} and Insup Noh and Cheal Kim",

year = "2014",

month = jun,

doi = "10.1039/c4nj00191e",

language = "English",

volume = "38",

pages = "2587--2594",

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T1 - A single chemosensor for multiple analytes

T2 - Fluorogenic detection of Zn2+ and OAc- ions in aqueous solution, and an application to bioimaging

AU - Park, Gyeong Jin

AU - Na, Yu Jeong

AU - Jo, Hyun Yong

AU - Lee, Seul Ah

AU - Kim, Ah Ram

AU - Noh, Insup

AU - Kim, Cheal

PY - 2014/6

Y1 - 2014/6

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AB - A new highly selective and sensitive chemosensor 1 for both Zn2+ and OAc- with off-on fluorescence behavior in aqueous solution was developed. The selectivity mechanism of 1 for zinc is based on a combinational effect of the inhibition of excited-state intramolecular proton transfer and CN isomerization, and chelation-enhanced fluorescence. As a practical application, in vitro studies with fibroblasts showed fluorescence in the presence of both the receptor 1 and Zn2+. Moreover, the deprotonated 1 can behave as a chemosensing system for turn-on detection of OAc- in preference over various other anions tested. Therefore, 1 can serve as 'one sensor for multiple analytes'. This journal is

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JF - New Journal of Chemistry

IS - 6

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A single chemosensor for multiple analytes: Fluorogenic detection of Zn²⁺ and OAc^- ions in aqueous solution, and an application to bioimaging

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