A strategically designed fluorescent turn-on chemodosimeter for selective detection of mercury (II) via dithioacetal deprotection reaction

Boeun Choi; Otgontsetseg Batsaikhan; Cheal Kim

doi:10.1002/jccs.70035

A strategically designed fluorescent turn-on chemodosimeter for selective detection of mercury (II) via dithioacetal deprotection reaction

Boeun Choi
, Otgontsetseg Batsaikhan
, Cheal Kim

Dept. of Fine Chemistry

Seoul National University of Science and Technology (SNUST)

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Mercury (Hg²⁺) is one of the toxic heavy metals and poses severe health risks and environmental pollution. Thus, we report on the strategic design and synthesis of a new fluorescent chemodosimeter, (Z)-3-(4-(1,3-dithian-2-yl)phenyl)-2-(naphthalen-2-yl)acrylonitrile (DTNA), for detecting Hg²⁺. In the presence of Hg²⁺, DTNA exhibited an intense cyan fluorescence turn-on, showing a significant Stokes shift (150 nm), a high quantum yield (Ф_F = 0.2721), and high selectivity with low interference from other metal ions. The Hg²⁺ recognition mechanism of DTNA was demonstrated as dithioacetal deprotection through ¹H NMR titration, ESI-MS, FT-IR, and DFT calculation. In particular, test papers coated with DTNA were successfully applied for monitoring Hg²⁺, enabling on-site detection.

Original language	English
Pages (from-to)	795-803
Number of pages	9
Journal	Journal of the Chinese Chemical Society
Volume	72
Issue number	7
DOIs	https://doi.org/10.1002/jccs.70035
State	Published - Jul 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

deprotection mechanism
fluorescence
fluorometric chemosensor
intramolecular charge transfer
mercury ion
test kit

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10.1002/jccs.70035

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title = "A strategically designed fluorescent turn-on chemodosimeter for selective detection of mercury (II) via dithioacetal deprotection reaction",

abstract = "Mercury (Hg2+) is one of the toxic heavy metals and poses severe health risks and environmental pollution. Thus, we report on the strategic design and synthesis of a new fluorescent chemodosimeter, (Z)-3-(4-(1,3-dithian-2-yl)phenyl)-2-(naphthalen-2-yl)acrylonitrile (DTNA), for detecting Hg2+. In the presence of Hg2+, DTNA exhibited an intense cyan fluorescence turn-on, showing a significant Stokes shift (150 nm), a high quantum yield (ФF = 0.2721), and high selectivity with low interference from other metal ions. The Hg2+ recognition mechanism of DTNA was demonstrated as dithioacetal deprotection through 1H NMR titration, ESI-MS, FT-IR, and DFT calculation. In particular, test papers coated with DTNA were successfully applied for monitoring Hg2+, enabling on-site detection.",

keywords = "deprotection mechanism, fluorescence, fluorometric chemosensor, intramolecular charge transfer, mercury ion, test kit",

author = "Boeun Choi and Otgontsetseg Batsaikhan and Cheal Kim",

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AU - Choi, Boeun

AU - Batsaikhan, Otgontsetseg

AU - Kim, Cheal

PY - 2025/7

Y1 - 2025/7

N2 - Mercury (Hg2+) is one of the toxic heavy metals and poses severe health risks and environmental pollution. Thus, we report on the strategic design and synthesis of a new fluorescent chemodosimeter, (Z)-3-(4-(1,3-dithian-2-yl)phenyl)-2-(naphthalen-2-yl)acrylonitrile (DTNA), for detecting Hg2+. In the presence of Hg2+, DTNA exhibited an intense cyan fluorescence turn-on, showing a significant Stokes shift (150 nm), a high quantum yield (ФF = 0.2721), and high selectivity with low interference from other metal ions. The Hg2+ recognition mechanism of DTNA was demonstrated as dithioacetal deprotection through 1H NMR titration, ESI-MS, FT-IR, and DFT calculation. In particular, test papers coated with DTNA were successfully applied for monitoring Hg2+, enabling on-site detection.

AB - Mercury (Hg2+) is one of the toxic heavy metals and poses severe health risks and environmental pollution. Thus, we report on the strategic design and synthesis of a new fluorescent chemodosimeter, (Z)-3-(4-(1,3-dithian-2-yl)phenyl)-2-(naphthalen-2-yl)acrylonitrile (DTNA), for detecting Hg2+. In the presence of Hg2+, DTNA exhibited an intense cyan fluorescence turn-on, showing a significant Stokes shift (150 nm), a high quantum yield (ФF = 0.2721), and high selectivity with low interference from other metal ions. The Hg2+ recognition mechanism of DTNA was demonstrated as dithioacetal deprotection through 1H NMR titration, ESI-MS, FT-IR, and DFT calculation. In particular, test papers coated with DTNA were successfully applied for monitoring Hg2+, enabling on-site detection.

KW - deprotection mechanism

KW - fluorescence

KW - fluorometric chemosensor

KW - intramolecular charge transfer

KW - mercury ion

KW - test kit

UR - https://www.scopus.com/pages/publications/105005410796

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DO - 10.1002/jccs.70035

M3 - Article

AN - SCOPUS:105005410796

SN - 0009-4536

VL - 72

SP - 795

EP - 803

JO - Journal of the Chinese Chemical Society

JF - Journal of the Chinese Chemical Society

IS - 7

ER -

A strategically designed fluorescent turn-on chemodosimeter for selective detection of mercury (II) via dithioacetal deprotection reaction

Abstract

UN SDGs

Keywords

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