A study of cancer cell metastasis using microfluidic transmigration device

Y. Fu; A. M.J. Vandongen; T. Bourouina; W. T. Park; M. Y. Je; J. M. Tsai; D. L. Kwong; A. Q. Liu

doi:10.1109/MEMSYS.2012.6170300

A study of cancer cell metastasis using microfluidic transmigration device

Y. Fu
, A. M.J. Vandongen
, T. Bourouina
, W. T. Park
, M. Y. Je
, J. M. Tsai
, D. L. Kwong
, A. Q. Liu

Dept. of Mechanical & Automotive Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

3 Scopus citations

Abstract

Metastasis of cancer cell was studied using microfluidic device. Migration of cells in the microchannel array mimics their transmigration in tissue capillaries during in vivo metastasis. Details of the morphological changes were recorded through high resolution imaging. Results showed that the deformation of cell nucleus is critical for the transmigration of breast cancer cell MDA-MB-231. Condensation of chromatin by drug plicamycinon significantly impaired their deformation abilities and subsequently reduced the transmigration by 2 to 3 fold for microchannel smaller than 10 μm x 5 μm. As transmigration is critical for cancer metastasis, the results will be useful in designing new anti-cancer therapy.

Original language	English
Title of host publication	2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012
Pages	773-776
Number of pages	4
DOIs	https://doi.org/10.1109/MEMSYS.2012.6170300
State	Published - 2012
Event	2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012 - Paris, France Duration: 29 Jan 2012 → 2 Feb 2012

Publication series

Name	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN (Print)	1084-6999

Conference

Conference	2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012
Country/Territory	France
City	Paris
Period	29/01/12 → 2/02/12

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1109/MEMSYS.2012.6170300

Cite this

Fu, Y., Vandongen, A. M. J., Bourouina, T., Park, W. T., Je, M. Y., Tsai, J. M., Kwong, D. L., & Liu, A. Q. (2012). A study of cancer cell metastasis using microfluidic transmigration device. In 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012 (pp. 773-776). Article 6170300 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). https://doi.org/10.1109/MEMSYS.2012.6170300

@inproceedings{43bdd837c3ec46b99df6f5a86b5f174a,

title = "A study of cancer cell metastasis using microfluidic transmigration device",

abstract = "Metastasis of cancer cell was studied using microfluidic device. Migration of cells in the microchannel array mimics their transmigration in tissue capillaries during in vivo metastasis. Details of the morphological changes were recorded through high resolution imaging. Results showed that the deformation of cell nucleus is critical for the transmigration of breast cancer cell MDA-MB-231. Condensation of chromatin by drug plicamycinon significantly impaired their deformation abilities and subsequently reduced the transmigration by 2 to 3 fold for microchannel smaller than 10 μm x 5 μm. As transmigration is critical for cancer metastasis, the results will be useful in designing new anti-cancer therapy.",

author = "Y. Fu and Vandongen, \{A. M.J.\} and T. Bourouina and Park, \{W. T.\} and Je, \{M. Y.\} and Tsai, \{J. M.\} and Kwong, \{D. L.\} and Liu, \{A. Q.\}",

year = "2012",

doi = "10.1109/MEMSYS.2012.6170300",

language = "English",

isbn = "9781467303248",

series = "Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)",

pages = "773--776",

booktitle = "2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012",

note = "2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012 ; Conference date: 29-01-2012 Through 02-02-2012",

}

Fu, Y, Vandongen, AMJ, Bourouina, T, Park, WT, Je, MY, Tsai, JM, Kwong, DL & Liu, AQ 2012, A study of cancer cell metastasis using microfluidic transmigration device. in 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012., 6170300, Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), pp. 773-776, 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012, Paris, France, 29/01/12. https://doi.org/10.1109/MEMSYS.2012.6170300

A study of cancer cell metastasis using microfluidic transmigration device. / Fu, Y.; Vandongen, A. M.J.; Bourouina, T. et al.
2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012. 2012. p. 773-776 6170300 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - A study of cancer cell metastasis using microfluidic transmigration device

AU - Fu, Y.

AU - Vandongen, A. M.J.

AU - Bourouina, T.

AU - Park, W. T.

AU - Je, M. Y.

AU - Tsai, J. M.

AU - Kwong, D. L.

AU - Liu, A. Q.

PY - 2012

Y1 - 2012

N2 - Metastasis of cancer cell was studied using microfluidic device. Migration of cells in the microchannel array mimics their transmigration in tissue capillaries during in vivo metastasis. Details of the morphological changes were recorded through high resolution imaging. Results showed that the deformation of cell nucleus is critical for the transmigration of breast cancer cell MDA-MB-231. Condensation of chromatin by drug plicamycinon significantly impaired their deformation abilities and subsequently reduced the transmigration by 2 to 3 fold for microchannel smaller than 10 μm x 5 μm. As transmigration is critical for cancer metastasis, the results will be useful in designing new anti-cancer therapy.

AB - Metastasis of cancer cell was studied using microfluidic device. Migration of cells in the microchannel array mimics their transmigration in tissue capillaries during in vivo metastasis. Details of the morphological changes were recorded through high resolution imaging. Results showed that the deformation of cell nucleus is critical for the transmigration of breast cancer cell MDA-MB-231. Condensation of chromatin by drug plicamycinon significantly impaired their deformation abilities and subsequently reduced the transmigration by 2 to 3 fold for microchannel smaller than 10 μm x 5 μm. As transmigration is critical for cancer metastasis, the results will be useful in designing new anti-cancer therapy.

UR - https://www.scopus.com/pages/publications/84860439523

U2 - 10.1109/MEMSYS.2012.6170300

DO - 10.1109/MEMSYS.2012.6170300

M3 - Conference contribution

AN - SCOPUS:84860439523

SN - 9781467303248

T3 - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)

SP - 773

EP - 776

BT - 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012

T2 - 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012

Y2 - 29 January 2012 through 2 February 2012

ER -

Fu Y, Vandongen AMJ, Bourouina T, Park WT, Je MY, Tsai JM et al. A study of cancer cell metastasis using microfluidic transmigration device. In 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012. 2012. p. 773-776. 6170300. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). doi: 10.1109/MEMSYS.2012.6170300

A study of cancer cell metastasis using microfluidic transmigration device

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