A water-soluble carboxylic-functionalized chemosensor for detecting Al3+ in aqueous media and living cells: Experimental and theoretical studies

Jae Jun Lee; Gyeong Jin Park; Yong Sung Kim; Sun Young Lee; Hyun Ji Lee; Insup Noh; Cheal Kim

doi:10.1016/j.bios.2015.02.038

A water-soluble carboxylic-functionalized chemosensor for detecting Al³⁺ in aqueous media and living cells: Experimental and theoretical studies

Jae Jun Lee, Gyeong Jin Park, Yong Sung Kim, Sun Young Lee, Hyun Ji Lee, Insup Noh, Cheal Kim

Seoul National University of Science and Technology (SNUST)

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

A new water-soluble carboxylic-functionalized chemosensor 1 was designed and synthesized. 1 exhibited the selective fluorescence enhancement toward aluminum ions with a 1:1 complexation stoichiometry in aqueous solution. The detection limit (24nM) of 1 for Al³⁺ is about two order lower than the WHO guideline (7.41μM) for the drinking water. 1 was successfully applied to living cells and real samples for detecting Al³⁺. Moreover, the sensing mechanism originated from the inhibited excited-state intramolecular proton transfer (ESIPT) process and the chelation-enhanced fluorescence (CHEF) effect, as supported by theoretical calculations.

Original language	English
Pages (from-to)	226-229
Number of pages	4
Journal	Biosensors and Bioelectronics
Volume	69
DOIs	https://doi.org/10.1016/j.bios.2015.02.038
State	Published - 5 Jul 2015

Keywords

Aluminum
Bio-imaging
Carboxylic-functionalized
Theoretical calculations
Water-soluble

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10.1016/j.bios.2015.02.038

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title = "A water-soluble carboxylic-functionalized chemosensor for detecting Al3+ in aqueous media and living cells: Experimental and theoretical studies",

abstract = "A new water-soluble carboxylic-functionalized chemosensor 1 was designed and synthesized. 1 exhibited the selective fluorescence enhancement toward aluminum ions with a 1:1 complexation stoichiometry in aqueous solution. The detection limit (24nM) of 1 for Al3+ is about two order lower than the WHO guideline (7.41μM) for the drinking water. 1 was successfully applied to living cells and real samples for detecting Al3+. Moreover, the sensing mechanism originated from the inhibited excited-state intramolecular proton transfer (ESIPT) process and the chelation-enhanced fluorescence (CHEF) effect, as supported by theoretical calculations.",

keywords = "Aluminum, Bio-imaging, Carboxylic-functionalized, Theoretical calculations, Water-soluble",

author = "\{Jun Lee\}, Jae and \{Jin Park\}, Gyeong and \{Sung Kim\}, Yong and \{Young Lee\}, Sun and \{Ji Lee\}, Hyun and Insup Noh and Cheal Kim",

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doi = "10.1016/j.bios.2015.02.038",

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AU - Jun Lee, Jae

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AU - Young Lee, Sun

AU - Ji Lee, Hyun

AU - Noh, Insup

AU - Kim, Cheal

PY - 2015/7/5

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AB - A new water-soluble carboxylic-functionalized chemosensor 1 was designed and synthesized. 1 exhibited the selective fluorescence enhancement toward aluminum ions with a 1:1 complexation stoichiometry in aqueous solution. The detection limit (24nM) of 1 for Al3+ is about two order lower than the WHO guideline (7.41μM) for the drinking water. 1 was successfully applied to living cells and real samples for detecting Al3+. Moreover, the sensing mechanism originated from the inhibited excited-state intramolecular proton transfer (ESIPT) process and the chelation-enhanced fluorescence (CHEF) effect, as supported by theoretical calculations.

KW - Aluminum

KW - Bio-imaging

KW - Carboxylic-functionalized

KW - Theoretical calculations

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A water-soluble carboxylic-functionalized chemosensor for detecting Al³⁺ in aqueous media and living cells: Experimental and theoretical studies

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Keywords

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