Alginate-chitosan Hydrogel Patch with Beta-glucan Nanoemulsion for Antibacterial Applications

Yonghyun Choi; Jaehee Jang; Hyung Jun Koo; Masayoshi Tanaka; Keun Heon Lee; Jonghoon Choi

doi:10.1007/s12257-020-0177-4

Alginate-chitosan Hydrogel Patch with Beta-glucan Nanoemulsion for Antibacterial Applications

Yonghyun Choi, Jaehee Jang, Hyung Jun Koo, Masayoshi Tanaka, Keun Heon Lee, Jonghoon Choi

Dept. of Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Natural polymer materials have high biocompatibility and are not toxic because they can decompose into metabolites in the body; thus, they are widely used as medical polymer materials as well as porous support materials. As a biopolymer, alginate has a negative charge; in contrast, chitosan has a positive charge. Therefore, when the two substances are mixed, they form a relatively stable structure by ionic bonding. Beta-glucan is known to contribute to material stability and have high skin penetration, skin moisturizing and soothing effects, and burn and wound healing effects. In this study, antimicrobial activity was assessed by preparing alginate-chitosan hydrogel patches containing beta-glucan nanoemulsions. This could contribute to the development of wound dressings with antibacterial properties.

Original language	English
Pages (from-to)	71-77
Number of pages	7
Journal	Biotechnology and Bioprocess Engineering
Volume	26
Issue number	1
DOIs	https://doi.org/10.1007/s12257-020-0177-4
State	Published - Jan 2021

Keywords

alginate
antibacterial
beta-glucan
biopolymer
chitosan

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10.1007/s12257-020-0177-4

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title = "Alginate-chitosan Hydrogel Patch with Beta-glucan Nanoemulsion for Antibacterial Applications",

abstract = "Natural polymer materials have high biocompatibility and are not toxic because they can decompose into metabolites in the body; thus, they are widely used as medical polymer materials as well as porous support materials. As a biopolymer, alginate has a negative charge; in contrast, chitosan has a positive charge. Therefore, when the two substances are mixed, they form a relatively stable structure by ionic bonding. Beta-glucan is known to contribute to material stability and have high skin penetration, skin moisturizing and soothing effects, and burn and wound healing effects. In this study, antimicrobial activity was assessed by preparing alginate-chitosan hydrogel patches containing beta-glucan nanoemulsions. This could contribute to the development of wound dressings with antibacterial properties.",

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T1 - Alginate-chitosan Hydrogel Patch with Beta-glucan Nanoemulsion for Antibacterial Applications

AU - Choi, Yonghyun

AU - Jang, Jaehee

AU - Koo, Hyung Jun

AU - Tanaka, Masayoshi

AU - Lee, Keun Heon

AU - Choi, Jonghoon

PY - 2021/1

Y1 - 2021/1

N2 - Natural polymer materials have high biocompatibility and are not toxic because they can decompose into metabolites in the body; thus, they are widely used as medical polymer materials as well as porous support materials. As a biopolymer, alginate has a negative charge; in contrast, chitosan has a positive charge. Therefore, when the two substances are mixed, they form a relatively stable structure by ionic bonding. Beta-glucan is known to contribute to material stability and have high skin penetration, skin moisturizing and soothing effects, and burn and wound healing effects. In this study, antimicrobial activity was assessed by preparing alginate-chitosan hydrogel patches containing beta-glucan nanoemulsions. This could contribute to the development of wound dressings with antibacterial properties.

AB - Natural polymer materials have high biocompatibility and are not toxic because they can decompose into metabolites in the body; thus, they are widely used as medical polymer materials as well as porous support materials. As a biopolymer, alginate has a negative charge; in contrast, chitosan has a positive charge. Therefore, when the two substances are mixed, they form a relatively stable structure by ionic bonding. Beta-glucan is known to contribute to material stability and have high skin penetration, skin moisturizing and soothing effects, and burn and wound healing effects. In this study, antimicrobial activity was assessed by preparing alginate-chitosan hydrogel patches containing beta-glucan nanoemulsions. This could contribute to the development of wound dressings with antibacterial properties.

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KW - beta-glucan

KW - biopolymer

KW - chitosan

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JO - Biotechnology and Bioprocess Engineering

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Alginate-chitosan Hydrogel Patch with Beta-glucan Nanoemulsion for Antibacterial Applications

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