(+)-Alpha-viniferin, a stilbene trimer from Caragana chamlague, inhibits acetylcholinesterase.

Sang Hyun Sung; So Young Kang; Ki Yong Lee; Mi Jung Park; Jeong Hun Kim; Jong Hee Park; Young Chul Kim; Jinwoong Kim; Young Choong Kim

doi:10.1248/bpb.25.125

(+)-Alpha-viniferin, a stilbene trimer from Caragana chamlague, inhibits acetylcholinesterase.

Sang Hyun Sung, So Young Kang, Ki Yong Lee, Mi Jung Park, Jeong Hun Kim, Jong Hee Park, Young Chul Kim, Jinwoong Kim, Young Choong Kim

Dept. of Optometry

Seoul National University

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

In the course of screening natural products for anti-acetylcholinesterase (AChE) activity, we found that a total methanolic extract of the underground parts of Caragana chamlague (Leguminosae) had significant inhibition towards AChE. Bioactivity-guided fractionation of the total methanolic extract resulted in the isolation and identification of two active stilbene oligomers, (+)-alpha-viniferin (1) and kobophenol A (2). Both 1 and 2 inhibited AChE activity in a dose-dependent manner, and the IC50 values of 1 and 2 were 2.0 and 115.8 microM, respectively. The AChE inhibitory activity of 1 was specific, reversible and noncompetitive.

Original language	English
Pages (from-to)	125-127
Number of pages	3
Journal	Biological & pharmaceutical bulletin
Volume	25
Issue number	1
DOIs	https://doi.org/10.1248/bpb.25.125
State	Published - Jan 2002

Access to Document

10.1248/bpb.25.125

Cite this

@article{6150369b9cfe4d5a87341292bb6dddef,

title = "(+)-Alpha-viniferin, a stilbene trimer from Caragana chamlague, inhibits acetylcholinesterase.",

abstract = "In the course of screening natural products for anti-acetylcholinesterase (AChE) activity, we found that a total methanolic extract of the underground parts of Caragana chamlague (Leguminosae) had significant inhibition towards AChE. Bioactivity-guided fractionation of the total methanolic extract resulted in the isolation and identification of two active stilbene oligomers, (+)-alpha-viniferin (1) and kobophenol A (2). Both 1 and 2 inhibited AChE activity in a dose-dependent manner, and the IC50 values of 1 and 2 were 2.0 and 115.8 microM, respectively. The AChE inhibitory activity of 1 was specific, reversible and noncompetitive.",

author = "Sung, \{Sang Hyun\} and Kang, \{So Young\} and Lee, \{Ki Yong\} and Park, \{Mi Jung\} and Kim, \{Jeong Hun\} and Park, \{Jong Hee\} and Kim, \{Young Chul\} and Jinwoong Kim and Kim, \{Young Choong\}",

year = "2002",

month = jan,

doi = "10.1248/bpb.25.125",

language = "English",

volume = "25",

pages = "125--127",

journal = "Biological \& pharmaceutical bulletin",

issn = "0918-6158",

number = "1",

}

TY - JOUR

T1 - (+)-Alpha-viniferin, a stilbene trimer from Caragana chamlague, inhibits acetylcholinesterase.

AU - Sung, Sang Hyun

AU - Kang, So Young

AU - Lee, Ki Yong

AU - Park, Mi Jung

AU - Kim, Jeong Hun

AU - Park, Jong Hee

AU - Kim, Young Chul

AU - Kim, Jinwoong

AU - Kim, Young Choong

PY - 2002/1

Y1 - 2002/1

N2 - In the course of screening natural products for anti-acetylcholinesterase (AChE) activity, we found that a total methanolic extract of the underground parts of Caragana chamlague (Leguminosae) had significant inhibition towards AChE. Bioactivity-guided fractionation of the total methanolic extract resulted in the isolation and identification of two active stilbene oligomers, (+)-alpha-viniferin (1) and kobophenol A (2). Both 1 and 2 inhibited AChE activity in a dose-dependent manner, and the IC50 values of 1 and 2 were 2.0 and 115.8 microM, respectively. The AChE inhibitory activity of 1 was specific, reversible and noncompetitive.

AB - In the course of screening natural products for anti-acetylcholinesterase (AChE) activity, we found that a total methanolic extract of the underground parts of Caragana chamlague (Leguminosae) had significant inhibition towards AChE. Bioactivity-guided fractionation of the total methanolic extract resulted in the isolation and identification of two active stilbene oligomers, (+)-alpha-viniferin (1) and kobophenol A (2). Both 1 and 2 inhibited AChE activity in a dose-dependent manner, and the IC50 values of 1 and 2 were 2.0 and 115.8 microM, respectively. The AChE inhibitory activity of 1 was specific, reversible and noncompetitive.

UR - https://www.scopus.com/pages/publications/0036364160

U2 - 10.1248/bpb.25.125

DO - 10.1248/bpb.25.125

M3 - Article

C2 - 11824541

AN - SCOPUS:0036364160

SN - 0918-6158

VL - 25

SP - 125

EP - 127

JO - Biological & pharmaceutical bulletin

JF - Biological & pharmaceutical bulletin

IS - 1

ER -

(+)-Alpha-viniferin, a stilbene trimer from Caragana chamlague, inhibits acetylcholinesterase.

Abstract

Access to Document

Other files and links

Fingerprint

Cite this