(+)-Alpha-viniferin, a stilbene trimer from Caragana chamlague, inhibits acetylcholinesterase.

Sang Hyun Sung; So Young Kang; Ki Yong Lee; Mi Jung Park; Jeong Hun Kim; Jong Hee Park; Young Chul Kim; Jinwoong Kim; Young Choong Kim

doi:10.1248/bpb.25.125

(+)-Alpha-viniferin, a stilbene trimer from Caragana chamlague, inhibits acetylcholinesterase.

Sang Hyun Sung
, So Young Kang
, Ki Yong Lee
, Mi Jung Park
, Jeong Hun Kim
, Jong Hee Park
, Young Chul Kim
, Jinwoong Kim
, Young Choong Kim

Dept. of Optometry

Seoul National University

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

In the course of screening natural products for anti-acetylcholinesterase (AChE) activity, we found that a total methanolic extract of the underground parts of Caragana chamlague (Leguminosae) had significant inhibition towards AChE. Bioactivity-guided fractionation of the total methanolic extract resulted in the isolation and identification of two active stilbene oligomers, (+)-alpha-viniferin (1) and kobophenol A (2). Both 1 and 2 inhibited AChE activity in a dose-dependent manner, and the IC50 values of 1 and 2 were 2.0 and 115.8 microM, respectively. The AChE inhibitory activity of 1 was specific, reversible and noncompetitive.

Original language	English
Pages (from-to)	125-127
Number of pages	3
Journal	Biological & pharmaceutical bulletin
Volume	25
Issue number	1
DOIs	https://doi.org/10.1248/bpb.25.125
State	Published - Jan 2002

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title = "(+)-Alpha-viniferin, a stilbene trimer from Caragana chamlague, inhibits acetylcholinesterase.",

abstract = "In the course of screening natural products for anti-acetylcholinesterase (AChE) activity, we found that a total methanolic extract of the underground parts of Caragana chamlague (Leguminosae) had significant inhibition towards AChE. Bioactivity-guided fractionation of the total methanolic extract resulted in the isolation and identification of two active stilbene oligomers, (+)-alpha-viniferin (1) and kobophenol A (2). Both 1 and 2 inhibited AChE activity in a dose-dependent manner, and the IC50 values of 1 and 2 were 2.0 and 115.8 microM, respectively. The AChE inhibitory activity of 1 was specific, reversible and noncompetitive.",

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doi = "10.1248/bpb.25.125",

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T1 - (+)-Alpha-viniferin, a stilbene trimer from Caragana chamlague, inhibits acetylcholinesterase.

AU - Sung, Sang Hyun

AU - Kang, So Young

AU - Lee, Ki Yong

AU - Park, Mi Jung

AU - Kim, Jeong Hun

AU - Park, Jong Hee

AU - Kim, Young Chul

AU - Kim, Jinwoong

AU - Kim, Young Choong

PY - 2002/1

Y1 - 2002/1

N2 - In the course of screening natural products for anti-acetylcholinesterase (AChE) activity, we found that a total methanolic extract of the underground parts of Caragana chamlague (Leguminosae) had significant inhibition towards AChE. Bioactivity-guided fractionation of the total methanolic extract resulted in the isolation and identification of two active stilbene oligomers, (+)-alpha-viniferin (1) and kobophenol A (2). Both 1 and 2 inhibited AChE activity in a dose-dependent manner, and the IC50 values of 1 and 2 were 2.0 and 115.8 microM, respectively. The AChE inhibitory activity of 1 was specific, reversible and noncompetitive.

AB - In the course of screening natural products for anti-acetylcholinesterase (AChE) activity, we found that a total methanolic extract of the underground parts of Caragana chamlague (Leguminosae) had significant inhibition towards AChE. Bioactivity-guided fractionation of the total methanolic extract resulted in the isolation and identification of two active stilbene oligomers, (+)-alpha-viniferin (1) and kobophenol A (2). Both 1 and 2 inhibited AChE activity in a dose-dependent manner, and the IC50 values of 1 and 2 were 2.0 and 115.8 microM, respectively. The AChE inhibitory activity of 1 was specific, reversible and noncompetitive.

UR - https://www.scopus.com/pages/publications/0036364160

U2 - 10.1248/bpb.25.125

DO - 10.1248/bpb.25.125

M3 - Article

C2 - 11824541

AN - SCOPUS:0036364160

SN - 0918-6158

VL - 25

SP - 125

EP - 127

JO - Biological & pharmaceutical bulletin

JF - Biological & pharmaceutical bulletin

IS - 1

ER -

(+)-Alpha-viniferin, a stilbene trimer from Caragana chamlague, inhibits acetylcholinesterase.

Abstract

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