Antithrombic effects of Piper retrofractum in a rat model of acute thrombosis: modulation of endothelial adhesion molecules and inflammatory factors

Seon Ha Jo; Soo Yeon Park; Jinhee Lee; Yuri Gwon; Ji Yeon Kim

doi:10.1007/s10068-024-01625-w

Antithrombic effects of Piper retrofractum in a rat model of acute thrombosis: modulation of endothelial adhesion molecules and inflammatory factors

Seon Ha Jo, Soo Yeon Park, Jinhee Lee, Yuri Gwon, Ji Yeon Kim

Dept. of Food Science and Technology

Research output: Contribution to journal › Article › peer-review

Abstract

Piper retrofractum (PR) is a tropical plant used as a spice in Southeast Asia. This study investigated the antithrombotic effect of PR in rats with acute thrombosis induced by collagen and epinephrine (CE). The rats were divided into four groups, control (CON), CE, PR15, and PR30, with PR administered at 15 and 30 mg/kg body weight. PR treatment significantly reduced paralysis time compared to the CE. The activated partial thromboplastin time in the PR15 group tended to decrease compared to the CE. Histologically, the both sample groups exhibited reduced blood clots within lung tissues and decreased E-selectin expression in aortic tissue. PR also tended to decrease cyclooxygenase levels and significantly reduce intracellular adhesion molecule 1 levels. PR has demonstrated potential for inhibiting thrombosis by regulating coagulation factors, adhesion molecules, and cyclooxygenase. This finding suggests its potential application as a therapeutic agent for lowering the risk of cardiovascular diseases.

Original language	English
Pages (from-to)	269-276
Number of pages	8
Journal	Food Science and Biotechnology
Volume	34
Issue number	1
DOIs	https://doi.org/10.1007/s10068-024-01625-w
State	Published - Jan 2025

Keywords

Coagulation
Collagen
Piper retrofractum
Piperine
Thrombosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s10068-024-01625-w

Cite this

@article{cbf9855cea01436c8695e61e7f612c3d,

title = "Antithrombic effects of Piper retrofractum in a rat model of acute thrombosis: modulation of endothelial adhesion molecules and inflammatory factors",

abstract = "Piper retrofractum (PR) is a tropical plant used as a spice in Southeast Asia. This study investigated the antithrombotic effect of PR in rats with acute thrombosis induced by collagen and epinephrine (CE). The rats were divided into four groups, control (CON), CE, PR15, and PR30, with PR administered at 15 and 30 mg/kg body weight. PR treatment significantly reduced paralysis time compared to the CE. The activated partial thromboplastin time in the PR15 group tended to decrease compared to the CE. Histologically, the both sample groups exhibited reduced blood clots within lung tissues and decreased E-selectin expression in aortic tissue. PR also tended to decrease cyclooxygenase levels and significantly reduce intracellular adhesion molecule 1 levels. PR has demonstrated potential for inhibiting thrombosis by regulating coagulation factors, adhesion molecules, and cyclooxygenase. This finding suggests its potential application as a therapeutic agent for lowering the risk of cardiovascular diseases.",

keywords = "Coagulation, Collagen, Piper retrofractum, Piperine, Thrombosis",

author = "Jo, \{Seon Ha\} and Park, \{Soo Yeon\} and Jinhee Lee and Yuri Gwon and Kim, \{Ji Yeon\}",

note = "Publisher Copyright: {\textcopyright} The Korean Society of Food Science and Technology 2024.",

year = "2025",

month = jan,

doi = "10.1007/s10068-024-01625-w",

language = "English",

volume = "34",

pages = "269--276",

journal = "Food Science and Biotechnology",

issn = "1226-7708",

number = "1",

}

TY - JOUR

T1 - Antithrombic effects of Piper retrofractum in a rat model of acute thrombosis

T2 - modulation of endothelial adhesion molecules and inflammatory factors

AU - Jo, Seon Ha

AU - Park, Soo Yeon

AU - Lee, Jinhee

AU - Gwon, Yuri

AU - Kim, Ji Yeon

N1 - Publisher Copyright: © The Korean Society of Food Science and Technology 2024.

PY - 2025/1

Y1 - 2025/1

N2 - Piper retrofractum (PR) is a tropical plant used as a spice in Southeast Asia. This study investigated the antithrombotic effect of PR in rats with acute thrombosis induced by collagen and epinephrine (CE). The rats were divided into four groups, control (CON), CE, PR15, and PR30, with PR administered at 15 and 30 mg/kg body weight. PR treatment significantly reduced paralysis time compared to the CE. The activated partial thromboplastin time in the PR15 group tended to decrease compared to the CE. Histologically, the both sample groups exhibited reduced blood clots within lung tissues and decreased E-selectin expression in aortic tissue. PR also tended to decrease cyclooxygenase levels and significantly reduce intracellular adhesion molecule 1 levels. PR has demonstrated potential for inhibiting thrombosis by regulating coagulation factors, adhesion molecules, and cyclooxygenase. This finding suggests its potential application as a therapeutic agent for lowering the risk of cardiovascular diseases.

AB - Piper retrofractum (PR) is a tropical plant used as a spice in Southeast Asia. This study investigated the antithrombotic effect of PR in rats with acute thrombosis induced by collagen and epinephrine (CE). The rats were divided into four groups, control (CON), CE, PR15, and PR30, with PR administered at 15 and 30 mg/kg body weight. PR treatment significantly reduced paralysis time compared to the CE. The activated partial thromboplastin time in the PR15 group tended to decrease compared to the CE. Histologically, the both sample groups exhibited reduced blood clots within lung tissues and decreased E-selectin expression in aortic tissue. PR also tended to decrease cyclooxygenase levels and significantly reduce intracellular adhesion molecule 1 levels. PR has demonstrated potential for inhibiting thrombosis by regulating coagulation factors, adhesion molecules, and cyclooxygenase. This finding suggests its potential application as a therapeutic agent for lowering the risk of cardiovascular diseases.

KW - Coagulation

KW - Collagen

KW - Piper retrofractum

KW - Piperine

KW - Thrombosis

UR - http://www.scopus.com/inward/record.url?scp=85197855401&partnerID=8YFLogxK

U2 - 10.1007/s10068-024-01625-w

DO - 10.1007/s10068-024-01625-w

M3 - Article

AN - SCOPUS:85197855401

SN - 1226-7708

VL - 34

SP - 269

EP - 276

JO - Food Science and Biotechnology

JF - Food Science and Biotechnology

IS - 1

ER -

Antithrombic effects of Piper retrofractum in a rat model of acute thrombosis: modulation of endothelial adhesion molecules and inflammatory factors

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this