Application of bioluminescence imaging to therapeutic intervention of herpes simplex virus type I - Thymidine kinase/ganciclovir in glioma

Su Jin Jang; Joo Hyun Kang; Kwang Il Kim; Tae Sup Lee; Yong Jin Lee; Kyo Chul Lee; Kwang Sun Woo; Wee Sup Chung; Hee Chung Kwon; Chun Jeih Ryu; Tae Hyun Choi; Chang Woon Choi; Sang Moo Lim; Gi Jeong Cheon

doi:10.1016/j.canlet.2010.04.028

Application of bioluminescence imaging to therapeutic intervention of herpes simplex virus type I - Thymidine kinase/ganciclovir in glioma

Su Jin Jang
, Joo Hyun Kang
, Kwang Il Kim
, Tae Sup Lee
, Yong Jin Lee
, Kyo Chul Lee
, Kwang Sun Woo
, Wee Sup Chung
, Hee Chung Kwon
, Chun Jeih Ryu
, Tae Hyun Choi
, Chang Woon Choi
, Sang Moo Lim
, Gi Jeong Cheon

Dept. of Biomedical Sciences

Korea Institute of Radiological and Medical Sciences
Sejong University

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Lentiviral vector containing the HSV1-tk and firefly luciferase (fLuc) gene was infected into C6 and C6-TL expressing HSV1-tk and fLuc gene was generated. C6-TL showed higher [¹²⁵I]IVDU uptake than C6. The survival rate of C6-TL decreased more rapidly with increasing GCV dose and was well correlated with fLuc activity. The images of microPET clearly demonstrated higher uptake of [¹⁸F]FHBG into the C6-TL tumor. Inhibition of tumor growth was observed in C6-TL tumor-bearing mice treated with GCV through tumor size measurement and bioluminescence imaging. The therapeutic effect of HSV1-tk/GCV system can be monitored using bioluminescent imaging and tumor size measurement.

Original language	English
Pages (from-to)	84-90
Number of pages	7
Journal	Cancer Letters
Volume	297
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2010.04.028
State	Published - Nov 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Glioma
HSV1-tk
Luciferase
Molecular imaging
Suicidal gene therapy

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10.1016/j.canlet.2010.04.028

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Jang, S. J., Kang, J. H., Kim, K. I., Lee, T. S., Lee, Y. J., Lee, K. C., Woo, K. S., Chung, W. S., Kwon, H. C., Ryu, C. J., Choi, T. H., Choi, C. W., Lim, S. M., & Cheon, G. J. (2010). Application of bioluminescence imaging to therapeutic intervention of herpes simplex virus type I - Thymidine kinase/ganciclovir in glioma. Cancer Letters, 297(1), 84-90. https://doi.org/10.1016/j.canlet.2010.04.028

@article{cf2c16e3e4cc43b9a7acc75db0a2be18,

title = "Application of bioluminescence imaging to therapeutic intervention of herpes simplex virus type I - Thymidine kinase/ganciclovir in glioma",

abstract = "Lentiviral vector containing the HSV1-tk and firefly luciferase (fLuc) gene was infected into C6 and C6-TL expressing HSV1-tk and fLuc gene was generated. C6-TL showed higher [125I]IVDU uptake than C6. The survival rate of C6-TL decreased more rapidly with increasing GCV dose and was well correlated with fLuc activity. The images of microPET clearly demonstrated higher uptake of [18F]FHBG into the C6-TL tumor. Inhibition of tumor growth was observed in C6-TL tumor-bearing mice treated with GCV through tumor size measurement and bioluminescence imaging. The therapeutic effect of HSV1-tk/GCV system can be monitored using bioluminescent imaging and tumor size measurement.",

keywords = "Glioma, HSV1-tk, Luciferase, Molecular imaging, Suicidal gene therapy",

author = "Jang, \{Su Jin\} and Kang, \{Joo Hyun\} and Kim, \{Kwang Il\} and Lee, \{Tae Sup\} and Lee, \{Yong Jin\} and Lee, \{Kyo Chul\} and Woo, \{Kwang Sun\} and Chung, \{Wee Sup\} and Kwon, \{Hee Chung\} and Ryu, \{Chun Jeih\} and Choi, \{Tae Hyun\} and Choi, \{Chang Woon\} and Lim, \{Sang Moo\} and Cheon, \{Gi Jeong\}",

year = "2010",

month = nov,

doi = "10.1016/j.canlet.2010.04.028",

language = "English",

volume = "297",

pages = "84--90",

journal = "Cancer Letters",

issn = "0304-3835",

number = "1",

}

Jang, SJ, Kang, JH, Kim, KI, Lee, TS, Lee, YJ, Lee, KC, Woo, KS, Chung, WS, Kwon, HC, Ryu, CJ, Choi, TH, Choi, CW, Lim, SM & Cheon, GJ 2010, 'Application of bioluminescence imaging to therapeutic intervention of herpes simplex virus type I - Thymidine kinase/ganciclovir in glioma', Cancer Letters, vol. 297, no. 1, pp. 84-90. https://doi.org/10.1016/j.canlet.2010.04.028

TY - JOUR

T1 - Application of bioluminescence imaging to therapeutic intervention of herpes simplex virus type I - Thymidine kinase/ganciclovir in glioma

AU - Jang, Su Jin

AU - Kang, Joo Hyun

AU - Kim, Kwang Il

AU - Lee, Tae Sup

AU - Lee, Yong Jin

AU - Lee, Kyo Chul

AU - Woo, Kwang Sun

AU - Chung, Wee Sup

AU - Kwon, Hee Chung

AU - Ryu, Chun Jeih

AU - Choi, Tae Hyun

AU - Choi, Chang Woon

AU - Lim, Sang Moo

AU - Cheon, Gi Jeong

PY - 2010/11

Y1 - 2010/11

N2 - Lentiviral vector containing the HSV1-tk and firefly luciferase (fLuc) gene was infected into C6 and C6-TL expressing HSV1-tk and fLuc gene was generated. C6-TL showed higher [125I]IVDU uptake than C6. The survival rate of C6-TL decreased more rapidly with increasing GCV dose and was well correlated with fLuc activity. The images of microPET clearly demonstrated higher uptake of [18F]FHBG into the C6-TL tumor. Inhibition of tumor growth was observed in C6-TL tumor-bearing mice treated with GCV through tumor size measurement and bioluminescence imaging. The therapeutic effect of HSV1-tk/GCV system can be monitored using bioluminescent imaging and tumor size measurement.

AB - Lentiviral vector containing the HSV1-tk and firefly luciferase (fLuc) gene was infected into C6 and C6-TL expressing HSV1-tk and fLuc gene was generated. C6-TL showed higher [125I]IVDU uptake than C6. The survival rate of C6-TL decreased more rapidly with increasing GCV dose and was well correlated with fLuc activity. The images of microPET clearly demonstrated higher uptake of [18F]FHBG into the C6-TL tumor. Inhibition of tumor growth was observed in C6-TL tumor-bearing mice treated with GCV through tumor size measurement and bioluminescence imaging. The therapeutic effect of HSV1-tk/GCV system can be monitored using bioluminescent imaging and tumor size measurement.

KW - Glioma

KW - HSV1-tk

KW - Luciferase

KW - Molecular imaging

KW - Suicidal gene therapy

UR - https://www.scopus.com/pages/publications/77956229309

U2 - 10.1016/j.canlet.2010.04.028

DO - 10.1016/j.canlet.2010.04.028

M3 - Article

C2 - 20819721

AN - SCOPUS:77956229309

SN - 0304-3835

VL - 297

SP - 84

EP - 90

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Application of bioluminescence imaging to therapeutic intervention of herpes simplex virus type I - Thymidine kinase/ganciclovir in glioma

Abstract

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Keywords

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