TY - GEN
T1 - BIOMANUFACTURING SCALE CHO CELL CLARIFICATION USING HARD PLASTIC SPIRAL INERTIAL MICROFLUIDIC DEVICE
AU - Jeon, Hyungkook
AU - Kwon, Taehong
AU - Yoon, Junghyo
AU - Han, Jongyoon
N1 - Publisher Copyright:
© 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Here, we developed a mass-producible hard plastic spiral inertial microfluidic device. Based on analysis of channel deformation, a predeveloped PDMS spiral device design was translated to its plastic version. Benefitting from material and fabrication advantages, the plastic spiral device provides reliable performance and mass-production. The developed plastic device showed a similar performance with its original PDMS version on Chinese Hamster Ovary (CHO) cell retention. Furthermore, CHO cell clarification with an industry-level-throughput (processing rate of 1 L/min per unit) was successfully demonstrated by using a multiplexed plastic device.
AB - Here, we developed a mass-producible hard plastic spiral inertial microfluidic device. Based on analysis of channel deformation, a predeveloped PDMS spiral device design was translated to its plastic version. Benefitting from material and fabrication advantages, the plastic spiral device provides reliable performance and mass-production. The developed plastic device showed a similar performance with its original PDMS version on Chinese Hamster Ovary (CHO) cell retention. Furthermore, CHO cell clarification with an industry-level-throughput (processing rate of 1 L/min per unit) was successfully demonstrated by using a multiplexed plastic device.
KW - Cell Clarification
KW - Channel deformation
KW - Inertial Microfluidics
KW - Mass-producible Plastic Device
UR - https://www.scopus.com/pages/publications/85136969459
M3 - Conference contribution
AN - SCOPUS:85136969459
T3 - MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
SP - 1211
EP - 1212
BT - MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PB - Chemical and Biological Microsystems Society
T2 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021
Y2 - 10 October 2021 through 14 October 2021
ER -