Catalytic Alkyne Arylation Using Traceless Directing Groups

Jung Woo Park; Bubwoong Kang; Vy M. Dong

doi:10.1002/anie.201804955

Catalytic Alkyne Arylation Using Traceless Directing Groups

Jung Woo Park, Bubwoong Kang, Vy M. Dong

Dept. of Fine Chemistry

University of California at Irvine

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

By using Pd⁰/Mandyphos, we achieved a three-component aminoarylation of alkynes to generate enamines, which are then hydrolyzed to either α-arylphenones or α,α-diarylketones. This Pd-catalyzed method overcomes established known pathways to enable the use of amines as traceless directing groups for C−C bond formation.

Original language	English
Pages (from-to)	13598-13602
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	57
Issue number	41
DOIs	https://doi.org/10.1002/anie.201804955
State	Published - 8 Oct 2018

Keywords

alkynes
aminoarylation
multicomponent coupling
palladium
regiocontrol

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10.1002/anie.201804955

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title = "Catalytic Alkyne Arylation Using Traceless Directing Groups",

abstract = "By using Pd0/Mandyphos, we achieved a three-component aminoarylation of alkynes to generate enamines, which are then hydrolyzed to either α-arylphenones or α,α-diarylketones. This Pd-catalyzed method overcomes established known pathways to enable the use of amines as traceless directing groups for C−C bond formation.",

keywords = "alkynes, aminoarylation, multicomponent coupling, palladium, regiocontrol",

author = "Park, \{Jung Woo\} and Bubwoong Kang and Dong, \{Vy M.\}",

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AU - Park, Jung Woo

AU - Kang, Bubwoong

AU - Dong, Vy M.

PY - 2018/10/8

Y1 - 2018/10/8

N2 - By using Pd0/Mandyphos, we achieved a three-component aminoarylation of alkynes to generate enamines, which are then hydrolyzed to either α-arylphenones or α,α-diarylketones. This Pd-catalyzed method overcomes established known pathways to enable the use of amines as traceless directing groups for C−C bond formation.

AB - By using Pd0/Mandyphos, we achieved a three-component aminoarylation of alkynes to generate enamines, which are then hydrolyzed to either α-arylphenones or α,α-diarylketones. This Pd-catalyzed method overcomes established known pathways to enable the use of amines as traceless directing groups for C−C bond formation.

KW - alkynes

KW - aminoarylation

KW - multicomponent coupling

KW - palladium

KW - regiocontrol

UR - https://www.scopus.com/pages/publications/85053554362

U2 - 10.1002/anie.201804955

DO - 10.1002/anie.201804955

M3 - Article

C2 - 30066448

AN - SCOPUS:85053554362

SN - 1433-7851

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 41

ER -

Catalytic Alkyne Arylation Using Traceless Directing Groups

Abstract

Keywords

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