Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: Structure-activity relationships

So Young Kang; Ki Yong Lee; Sang Hyun Sung; Mi Jung Park; Young Choong Kim

doi:10.1021/np000441w

Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: Structure-activity relationships

So Young Kang, Ki Yong Lee, Sang Hyun Sung, Mi Jung Park, Young Choong Kim

Dept. of Optometry

Seoul National University

Research output: Contribution to journal › Article › peer-review

232 Scopus citations

Abstract

Acetylcholinesterase (AChE) inhibitory activity-guided fractionation of Angelica gigas led to isolation and identification of a new coumarin, peucedanone (12), and isolation of 11 known coumarins. Among them, decursinol (1) represented the highest inhibitory activity toward AChE in vitro. The correlation of the inhibitory activities of the coumarins toward AChE with their chemical structures was studied.

Original language	English
Pages (from-to)	683-685
Number of pages	3
Journal	Journal of Natural Products
Volume	64
Issue number	5
DOIs	https://doi.org/10.1021/np000441w
State	Published - May 2001

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10.1021/np000441w

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abstract = "Acetylcholinesterase (AChE) inhibitory activity-guided fractionation of Angelica gigas led to isolation and identification of a new coumarin, peucedanone (12), and isolation of 11 known coumarins. Among them, decursinol (1) represented the highest inhibitory activity toward AChE in vitro. The correlation of the inhibitory activities of the coumarins toward AChE with their chemical structures was studied.",

author = "Kang, \{So Young\} and Lee, \{Ki Yong\} and Sung, \{Sang Hyun\} and Park, \{Mi Jung\} and Kim, \{Young Choong\}",

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AU - Park, Mi Jung

AU - Kim, Young Choong

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AB - Acetylcholinesterase (AChE) inhibitory activity-guided fractionation of Angelica gigas led to isolation and identification of a new coumarin, peucedanone (12), and isolation of 11 known coumarins. Among them, decursinol (1) represented the highest inhibitory activity toward AChE in vitro. The correlation of the inhibitory activities of the coumarins toward AChE with their chemical structures was studied.

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Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: Structure-activity relationships

Abstract

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