Cucurbit[6]uril-based polymer nanocapsules as a non-covalent and modular bioimaging platform for multimodal: In vivo imaging

Sungwan Kim; Gyeongwon Yun; Suman Khan; Jinhwan Kim; James Murray; Yeong Mi Lee; Won Jong Kim; Gyudong Lee; Sungjee Kim; Dinesh Shetty; Joo Hyun Kang; Jung Young Kim; Kyeng Min Park; Kimoon Kim

doi:10.1039/c7mh00038c

Cucurbit[6]uril-based polymer nanocapsules as a non-covalent and modular bioimaging platform for multimodal: In vivo imaging

Sungwan Kim
, Gyeongwon Yun
, Suman Khan
, Jinhwan Kim
, James Murray
, Yeong Mi Lee
, Won Jong Kim
, Gyudong Lee
, Sungjee Kim
, Dinesh Shetty
, Joo Hyun Kang
, Jung Young Kim
, Kyeng Min Park
, Kimoon Kim

Dept. of Biomedical Sciences

Institute for Basic Science
Pohang University of Science and Technology
Korea Institute of Radiological and Medical Sciences
University of Science and Technology UST

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Cucurbit[6]uril (CB[6])-based polymer nanocapsules (CB[6]PNs) were used as a multimodal platform for cancer-targeted in vivo bioimaging. By taking advantage of the strong and robust host-guest interaction between CB[6] and spermidine (spmd) under in vivo conditions, the surface of the CB[6]PNs was non-covalently modified with various spmd-conjugated functionalities in a modular manner. The CB[6]PNs modified with imaging probes and targeting ligands showed tumor targeted PET and NIR imaging in mice. This proof of concept demonstrates the potential of non-covalently modified nanomaterials in real world in vivo systems.

Original language	English
Pages (from-to)	450-455
Number of pages	6
Journal	Materials Horizons
Volume	4
Issue number	3
DOIs	https://doi.org/10.1039/c7mh00038c
State	Published - 2017

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1039/c7mh00038c

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title = "Cucurbit[6]uril-based polymer nanocapsules as a non-covalent and modular bioimaging platform for multimodal: In vivo imaging",

abstract = "Cucurbit[6]uril (CB[6])-based polymer nanocapsules (CB[6]PNs) were used as a multimodal platform for cancer-targeted in vivo bioimaging. By taking advantage of the strong and robust host-guest interaction between CB[6] and spermidine (spmd) under in vivo conditions, the surface of the CB[6]PNs was non-covalently modified with various spmd-conjugated functionalities in a modular manner. The CB[6]PNs modified with imaging probes and targeting ligands showed tumor targeted PET and NIR imaging in mice. This proof of concept demonstrates the potential of non-covalently modified nanomaterials in real world in vivo systems.",

author = "Sungwan Kim and Gyeongwon Yun and Suman Khan and Jinhwan Kim and James Murray and Lee, \{Yeong Mi\} and Kim, \{Won Jong\} and Gyudong Lee and Sungjee Kim and Dinesh Shetty and Kang, \{Joo Hyun\} and Kim, \{Jung Young\} and Park, \{Kyeng Min\} and Kimoon Kim",

note = "Publisher Copyright: {\textcopyright} 2017 The Royal Society of Chemistry.",

year = "2017",

doi = "10.1039/c7mh00038c",

language = "English",

volume = "4",

pages = "450--455",

journal = "Materials Horizons",

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T1 - Cucurbit[6]uril-based polymer nanocapsules as a non-covalent and modular bioimaging platform for multimodal

T2 - In vivo imaging

AU - Kim, Sungwan

AU - Yun, Gyeongwon

AU - Khan, Suman

AU - Kim, Jinhwan

AU - Murray, James

AU - Lee, Yeong Mi

AU - Kim, Won Jong

AU - Lee, Gyudong

AU - Kim, Sungjee

AU - Shetty, Dinesh

AU - Kang, Joo Hyun

AU - Kim, Jung Young

AU - Park, Kyeng Min

AU - Kim, Kimoon

PY - 2017

Y1 - 2017

N2 - Cucurbit[6]uril (CB[6])-based polymer nanocapsules (CB[6]PNs) were used as a multimodal platform for cancer-targeted in vivo bioimaging. By taking advantage of the strong and robust host-guest interaction between CB[6] and spermidine (spmd) under in vivo conditions, the surface of the CB[6]PNs was non-covalently modified with various spmd-conjugated functionalities in a modular manner. The CB[6]PNs modified with imaging probes and targeting ligands showed tumor targeted PET and NIR imaging in mice. This proof of concept demonstrates the potential of non-covalently modified nanomaterials in real world in vivo systems.

AB - Cucurbit[6]uril (CB[6])-based polymer nanocapsules (CB[6]PNs) were used as a multimodal platform for cancer-targeted in vivo bioimaging. By taking advantage of the strong and robust host-guest interaction between CB[6] and spermidine (spmd) under in vivo conditions, the surface of the CB[6]PNs was non-covalently modified with various spmd-conjugated functionalities in a modular manner. The CB[6]PNs modified with imaging probes and targeting ligands showed tumor targeted PET and NIR imaging in mice. This proof of concept demonstrates the potential of non-covalently modified nanomaterials in real world in vivo systems.

UR - https://www.scopus.com/pages/publications/85021815345

U2 - 10.1039/c7mh00038c

DO - 10.1039/c7mh00038c

M3 - Article

AN - SCOPUS:85021815345

SN - 2051-6347

VL - 4

SP - 450

EP - 455

JO - Materials Horizons

JF - Materials Horizons

IS - 3

ER -

Cucurbit[6]uril-based polymer nanocapsules as a non-covalent and modular bioimaging platform for multimodal: In vivo imaging

Abstract

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