Detecting and bioimaging of hypochlorite by a conjugated fluorescent chemosensor based on thioamide

Ahran Kim; Minji Lee; Hangyul Lee; Haeri So; Soomin Jeong; Ki Tae Kim; Cheal Kim

doi:10.1016/j.jphotochem.2021.113531

Detecting and bioimaging of hypochlorite by a conjugated fluorescent chemosensor based on thioamide

Ahran Kim
, Minji Lee
, Hangyul Lee
, Haeri So
, Soomin Jeong
, Ki Tae Kim
, Cheal Kim

Seoul National University of Science and Technology (SNUST)

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

A novel thioamide-based conjugated probe SNC, (E)-2-((E)-3-(4-(dimethylamino)phenyl)allylidene)-N,N-dimethylhydrazine-1-carbothioamide, has been designed. Probe SNC could selectively recognize ClO^- in aqueous media through fluorescence turn-off and sensitively detect ClO^- down to 0.90 μM. In addition, successful detection of hypochlorite was achieved for practical applications in living zebrafish and water samples, and the detection limit turned out to be 2.26 μM. Detection process between SNC and hypochlorite was illustrated through UV–Vis spectroscopy, ¹H NMR titration, ESI-mass and DFT study.

Original language	English
Article number	113531
Journal	Journal of Photochemistry and Photobiology A: Chemistry
Volume	421
DOIs	https://doi.org/10.1016/j.jphotochem.2021.113531
State	Published - 1 Dec 2021

Keywords

Chemosensor
Computational theory
Hypochlorite
Thioamide
Zebrafish

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10.1016/j.jphotochem.2021.113531

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title = "Detecting and bioimaging of hypochlorite by a conjugated fluorescent chemosensor based on thioamide",

abstract = "A novel thioamide-based conjugated probe SNC, (E)-2-((E)-3-(4-(dimethylamino)phenyl)allylidene)-N,N-dimethylhydrazine-1-carbothioamide, has been designed. Probe SNC could selectively recognize ClO- in aqueous media through fluorescence turn-off and sensitively detect ClO- down to 0.90 μM. In addition, successful detection of hypochlorite was achieved for practical applications in living zebrafish and water samples, and the detection limit turned out to be 2.26 μM. Detection process between SNC and hypochlorite was illustrated through UV–Vis spectroscopy, 1H NMR titration, ESI-mass and DFT study.",

keywords = "Chemosensor, Computational theory, Hypochlorite, Thioamide, Zebrafish",

author = "Ahran Kim and Minji Lee and Hangyul Lee and Haeri So and Soomin Jeong and Kim, \{Ki Tae\} and Cheal Kim",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",

year = "2021",

month = dec,

day = "1",

doi = "10.1016/j.jphotochem.2021.113531",

language = "English",

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journal = "Journal of Photochemistry and Photobiology A: Chemistry",

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TY - JOUR

T1 - Detecting and bioimaging of hypochlorite by a conjugated fluorescent chemosensor based on thioamide

AU - Kim, Ahran

AU - Lee, Minji

AU - Lee, Hangyul

AU - So, Haeri

AU - Jeong, Soomin

AU - Kim, Ki Tae

AU - Kim, Cheal

PY - 2021/12/1

Y1 - 2021/12/1

N2 - A novel thioamide-based conjugated probe SNC, (E)-2-((E)-3-(4-(dimethylamino)phenyl)allylidene)-N,N-dimethylhydrazine-1-carbothioamide, has been designed. Probe SNC could selectively recognize ClO- in aqueous media through fluorescence turn-off and sensitively detect ClO- down to 0.90 μM. In addition, successful detection of hypochlorite was achieved for practical applications in living zebrafish and water samples, and the detection limit turned out to be 2.26 μM. Detection process between SNC and hypochlorite was illustrated through UV–Vis spectroscopy, 1H NMR titration, ESI-mass and DFT study.

AB - A novel thioamide-based conjugated probe SNC, (E)-2-((E)-3-(4-(dimethylamino)phenyl)allylidene)-N,N-dimethylhydrazine-1-carbothioamide, has been designed. Probe SNC could selectively recognize ClO- in aqueous media through fluorescence turn-off and sensitively detect ClO- down to 0.90 μM. In addition, successful detection of hypochlorite was achieved for practical applications in living zebrafish and water samples, and the detection limit turned out to be 2.26 μM. Detection process between SNC and hypochlorite was illustrated through UV–Vis spectroscopy, 1H NMR titration, ESI-mass and DFT study.

KW - Chemosensor

KW - Computational theory

KW - Hypochlorite

KW - Thioamide

KW - Zebrafish

UR - https://www.scopus.com/pages/publications/85114703653

U2 - 10.1016/j.jphotochem.2021.113531

DO - 10.1016/j.jphotochem.2021.113531

M3 - Article

AN - SCOPUS:85114703653

SN - 1010-6030

VL - 421

JO - Journal of Photochemistry and Photobiology A: Chemistry

JF - Journal of Photochemistry and Photobiology A: Chemistry

M1 - 113531

ER -

Detecting and bioimaging of hypochlorite by a conjugated fluorescent chemosensor based on thioamide

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Keywords

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