Detection of zinc (II) and hypochlorite by a thiourea-based chemosensor via two emission channels and its application in vivo

Haeri So; Hanna Cho; Hangyul Lee; Minh Cong Tran; Ki Tae Kim; Cheal Kim

doi:10.1016/j.microc.2020.104788

Detection of zinc (II) and hypochlorite by a thiourea-based chemosensor via two emission channels and its application in vivo

Haeri So, Hanna Cho, Hangyul Lee, Minh Cong Tran, Ki Tae Kim, Cheal Kim

Seoul National University of Science and Technology (SNUST)

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

A novel thiourea-based chemosensor THB (N-benzhydryl-2-(thiophene-2-carbonyl)hydrazine-1-carbothioamide) was designed and investigated. THB had the capability to detect zinc ion and hypochlorite in a near-perfect aqueous media via different fluorescent emission channels. Limits of detection (LOD) were determined to be 0.67 µM for zinc ion and 0.28 µM for hypochlorite. Importantly, THB could successfully monitor both zinc ion and hypochlorite in zebrafish. Response mechanisms of THB to zinc ion and hypochlorite were demonstrated by ¹H NMR titrations, theoretical calculations, fluorescent and UV–vis spectral variations, and ESI-mass.

Original language	English
Article number	104788
Journal	Microchemical Journal
Volume	155
DOIs	https://doi.org/10.1016/j.microc.2020.104788
State	Published - Jun 2020

Keywords

Fluorometric analysis
Hypochlorite
Theoretical calculations
Water sample
Zebrafish
Zinc ion

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10.1016/j.microc.2020.104788

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title = "Detection of zinc (II) and hypochlorite by a thiourea-based chemosensor via two emission channels and its application in vivo",

abstract = "A novel thiourea-based chemosensor THB (N-benzhydryl-2-(thiophene-2-carbonyl)hydrazine-1-carbothioamide) was designed and investigated. THB had the capability to detect zinc ion and hypochlorite in a near-perfect aqueous media via different fluorescent emission channels. Limits of detection (LOD) were determined to be 0.67 µM for zinc ion and 0.28 µM for hypochlorite. Importantly, THB could successfully monitor both zinc ion and hypochlorite in zebrafish. Response mechanisms of THB to zinc ion and hypochlorite were demonstrated by 1H NMR titrations, theoretical calculations, fluorescent and UV–vis spectral variations, and ESI-mass.",

keywords = "Fluorometric analysis, Hypochlorite, Theoretical calculations, Water sample, Zebrafish, Zinc ion",

author = "Haeri So and Hanna Cho and Hangyul Lee and Tran, \{Minh Cong\} and Kim, \{Ki Tae\} and Cheal Kim",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",

year = "2020",

month = jun,

doi = "10.1016/j.microc.2020.104788",

language = "English",

volume = "155",

journal = "Microchemical Journal",

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TY - JOUR

T1 - Detection of zinc (II) and hypochlorite by a thiourea-based chemosensor via two emission channels and its application in vivo

AU - So, Haeri

AU - Cho, Hanna

AU - Lee, Hangyul

AU - Tran, Minh Cong

AU - Kim, Ki Tae

AU - Kim, Cheal

PY - 2020/6

Y1 - 2020/6

N2 - A novel thiourea-based chemosensor THB (N-benzhydryl-2-(thiophene-2-carbonyl)hydrazine-1-carbothioamide) was designed and investigated. THB had the capability to detect zinc ion and hypochlorite in a near-perfect aqueous media via different fluorescent emission channels. Limits of detection (LOD) were determined to be 0.67 µM for zinc ion and 0.28 µM for hypochlorite. Importantly, THB could successfully monitor both zinc ion and hypochlorite in zebrafish. Response mechanisms of THB to zinc ion and hypochlorite were demonstrated by 1H NMR titrations, theoretical calculations, fluorescent and UV–vis spectral variations, and ESI-mass.

AB - A novel thiourea-based chemosensor THB (N-benzhydryl-2-(thiophene-2-carbonyl)hydrazine-1-carbothioamide) was designed and investigated. THB had the capability to detect zinc ion and hypochlorite in a near-perfect aqueous media via different fluorescent emission channels. Limits of detection (LOD) were determined to be 0.67 µM for zinc ion and 0.28 µM for hypochlorite. Importantly, THB could successfully monitor both zinc ion and hypochlorite in zebrafish. Response mechanisms of THB to zinc ion and hypochlorite were demonstrated by 1H NMR titrations, theoretical calculations, fluorescent and UV–vis spectral variations, and ESI-mass.

KW - Fluorometric analysis

KW - Hypochlorite

KW - Theoretical calculations

KW - Water sample

KW - Zebrafish

KW - Zinc ion

UR - https://www.scopus.com/pages/publications/85081011931

U2 - 10.1016/j.microc.2020.104788

DO - 10.1016/j.microc.2020.104788

M3 - Article

AN - SCOPUS:85081011931

SN - 0026-265X

VL - 155

JO - Microchemical Journal

JF - Microchemical Journal

M1 - 104788

ER -

Detection of zinc (II) and hypochlorite by a thiourea-based chemosensor via two emission channels and its application in vivo

Abstract

Keywords

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