Detection of Zinc(II) by a Fluorescence Chemosensor Based on Benzofuran in Aqueous Media and Live Cells

Hyo Jung Jang; Ahran Kim; Jae Min Jung; Misun Lee; Mi Hee Lim; Cheal Kim

doi:10.1002/bkcs.11608

Detection of Zinc(II) by a Fluorescence Chemosensor Based on Benzofuran in Aqueous Media and Live Cells

Hyo Jung Jang, Ahran Kim, Jae Min Jung, Misun Lee, Mi Hee Lim, Cheal Kim

Dept. of Fine Chemistry

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

A fluorescence chemosensor HBC ((E)-3-((2-hydroxybenzylidene)amino)benzofuran-2-carboxamide) for detection of Zn²⁺ was designed by the condensation combination of 3-aminobenzofuran-2-carboxamide and salicylaldehyde. Sensor HBC showed an excellent selective “off–on” fluorescent response toward Zn²⁺. Detection limit (1.08 μM) for Zn²⁺ was much lower than the WHO standard (76.0 μM). Importantly, HBC could recognize and quantify Zn²⁺ in real samples and live cells. Detection process of HBC for Zn²⁺ was explained by ESI-mass, Job plot, UV–Vis and ¹H NMR titrations, and theoretical calculations.

Original language	English
Pages (from-to)	1373-1379
Number of pages	7
Journal	Bulletin of the Korean Chemical Society
Volume	39
Issue number	12
DOIs	https://doi.org/10.1002/bkcs.11608
State	Published - Dec 2018

Keywords

Cell imaging
Fluorescence sensor
Theoretical calculations
Zinc

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10.1002/bkcs.11608

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title = "Detection of Zinc(II) by a Fluorescence Chemosensor Based on Benzofuran in Aqueous Media and Live Cells",

abstract = "A fluorescence chemosensor HBC ((E)-3-((2-hydroxybenzylidene)amino)benzofuran-2-carboxamide) for detection of Zn2+ was designed by the condensation combination of 3-aminobenzofuran-2-carboxamide and salicylaldehyde. Sensor HBC showed an excellent selective “off–on” fluorescent response toward Zn2+. Detection limit (1.08 μM) for Zn2+ was much lower than the WHO standard (76.0 μM). Importantly, HBC could recognize and quantify Zn2+ in real samples and live cells. Detection process of HBC for Zn2+ was explained by ESI-mass, Job plot, UV–Vis and 1H NMR titrations, and theoretical calculations.",

keywords = "Cell imaging, Fluorescence sensor, Theoretical calculations, Zinc",

author = "Jang, \{Hyo Jung\} and Ahran Kim and Jung, \{Jae Min\} and Misun Lee and Lim, \{Mi Hee\} and Cheal Kim",

note = "Publisher Copyright: {\textcopyright} 2018 Korean Chemical Society, Seoul \& Wiley-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2018",

month = dec,

doi = "10.1002/bkcs.11608",

language = "English",

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T1 - Detection of Zinc(II) by a Fluorescence Chemosensor Based on Benzofuran in Aqueous Media and Live Cells

AU - Jang, Hyo Jung

AU - Kim, Ahran

AU - Jung, Jae Min

AU - Lee, Misun

AU - Lim, Mi Hee

AU - Kim, Cheal

PY - 2018/12

Y1 - 2018/12

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AB - A fluorescence chemosensor HBC ((E)-3-((2-hydroxybenzylidene)amino)benzofuran-2-carboxamide) for detection of Zn2+ was designed by the condensation combination of 3-aminobenzofuran-2-carboxamide and salicylaldehyde. Sensor HBC showed an excellent selective “off–on” fluorescent response toward Zn2+. Detection limit (1.08 μM) for Zn2+ was much lower than the WHO standard (76.0 μM). Importantly, HBC could recognize and quantify Zn2+ in real samples and live cells. Detection process of HBC for Zn2+ was explained by ESI-mass, Job plot, UV–Vis and 1H NMR titrations, and theoretical calculations.

KW - Cell imaging

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KW - Theoretical calculations

KW - Zinc

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IS - 12

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Detection of Zinc(II) by a Fluorescence Chemosensor Based on Benzofuran in Aqueous Media and Live Cells

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Keywords

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