Developing a new chemosensor targeting zinc ion based on two types of quinoline platform

Ahran Kim; Hangyul Lee; Dongju Yun; Ukhyun Jung; Ki Tae Kim; Cheal Kim

doi:10.1016/j.saa.2020.118652

Developing a new chemosensor targeting zinc ion based on two types of quinoline platform

Ahran Kim, Hangyul Lee, Dongju Yun, Ukhyun Jung, Ki Tae Kim, Cheal Kim

Seoul National University of Science and Technology (SNUST)

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

A chemosensor DQ (2-(2-(quinolin-2-yl)hydrazinyl)-N-(quinolin-8-yl)acetamide), based on two quinoline moieties, has been synthesized. DQ could detect zinc ion through fluorescence turn-on in aqueous media. Limit of detection was calculated as 0.07 μM, far lower than the standard of WHO for zinc ion. The practicality of DQ was demonstrated via the successful results of reusability with EDTA, easy detection on the test strip, and precise quantification in real water samples. Additionally, sensor DQ could be applied to bioimaging of zinc ion in zebrafish. Sensing process of zinc ion by DQ was studied through fluorescence and UV–Vis spectroscopy, ¹H NMR titration, and ESI-mass spectrometry.

Original language	English
Article number	118652
Journal	Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Volume	241
DOIs	https://doi.org/10.1016/j.saa.2020.118652
State	Published - 5 Nov 2020

Keywords

Chemosensor
Fluorescence
Quinoline
Zebrafish
Zinc

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title = "Developing a new chemosensor targeting zinc ion based on two types of quinoline platform",

abstract = "A chemosensor DQ (2-(2-(quinolin-2-yl)hydrazinyl)-N-(quinolin-8-yl)acetamide), based on two quinoline moieties, has been synthesized. DQ could detect zinc ion through fluorescence turn-on in aqueous media. Limit of detection was calculated as 0.07 μM, far lower than the standard of WHO for zinc ion. The practicality of DQ was demonstrated via the successful results of reusability with EDTA, easy detection on the test strip, and precise quantification in real water samples. Additionally, sensor DQ could be applied to bioimaging of zinc ion in zebrafish. Sensing process of zinc ion by DQ was studied through fluorescence and UV–Vis spectroscopy, 1H NMR titration, and ESI-mass spectrometry.",

keywords = "Chemosensor, Fluorescence, Quinoline, Zebrafish, Zinc",

author = "Ahran Kim and Hangyul Lee and Dongju Yun and Ukhyun Jung and Kim, \{Ki Tae\} and Cheal Kim",

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doi = "10.1016/j.saa.2020.118652",

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T1 - Developing a new chemosensor targeting zinc ion based on two types of quinoline platform

AU - Kim, Ahran

AU - Lee, Hangyul

AU - Yun, Dongju

AU - Jung, Ukhyun

AU - Kim, Ki Tae

AU - Kim, Cheal

PY - 2020/11/5

Y1 - 2020/11/5

N2 - A chemosensor DQ (2-(2-(quinolin-2-yl)hydrazinyl)-N-(quinolin-8-yl)acetamide), based on two quinoline moieties, has been synthesized. DQ could detect zinc ion through fluorescence turn-on in aqueous media. Limit of detection was calculated as 0.07 μM, far lower than the standard of WHO for zinc ion. The practicality of DQ was demonstrated via the successful results of reusability with EDTA, easy detection on the test strip, and precise quantification in real water samples. Additionally, sensor DQ could be applied to bioimaging of zinc ion in zebrafish. Sensing process of zinc ion by DQ was studied through fluorescence and UV–Vis spectroscopy, 1H NMR titration, and ESI-mass spectrometry.

AB - A chemosensor DQ (2-(2-(quinolin-2-yl)hydrazinyl)-N-(quinolin-8-yl)acetamide), based on two quinoline moieties, has been synthesized. DQ could detect zinc ion through fluorescence turn-on in aqueous media. Limit of detection was calculated as 0.07 μM, far lower than the standard of WHO for zinc ion. The practicality of DQ was demonstrated via the successful results of reusability with EDTA, easy detection on the test strip, and precise quantification in real water samples. Additionally, sensor DQ could be applied to bioimaging of zinc ion in zebrafish. Sensing process of zinc ion by DQ was studied through fluorescence and UV–Vis spectroscopy, 1H NMR titration, and ESI-mass spectrometry.

KW - Chemosensor

KW - Fluorescence

KW - Quinoline

KW - Zebrafish

KW - Zinc

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SN - 1386-1425

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JO - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy

JF - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy

M1 - 118652

ER -

Developing a new chemosensor targeting zinc ion based on two types of quinoline platform

Abstract

Keywords

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