Development of assessment technology for a rat myocardial infarct model using integrated PET/CT and MRI images

Sang Keun Woo; Gi Jeong Cheon; Kyeong Min Kim; Won Ho Lee; Yong Jin Lee; Min Hwan Kim; Joo Hyun Kang; Young Hoon Ji; Chang Woon Choi; Sang Moo Lim

doi:10.1109/NSSMIC.2010.5874283

Development of assessment technology for a rat myocardial infarct model using integrated PET/CT and MRI images

Sang Keun Woo
, Gi Jeong Cheon
, Kyeong Min Kim
, Won Ho Lee
, Yong Jin Lee
, Min Hwan Kim
, Joo Hyun Kang
, Young Hoon Ji
, Chang Woon Choi
, Sang Moo Lim

Dept. of Biomedical Sciences

Molecular Imaging Research Center
Korea Institute of Radiological and Medical Sciences

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

The aim of this study was to improve quantitative assessment of rat myocardial infarct size using attenuation corrected PET polar map with gated CT image and MRI polarmap. The PET/CT images obtained with a small animal PET/CT scanner. Gating was realized with the help of an external trigger device. Contrast enhanced FLASH sequence MRI image was acquired with a 3-T clinical MRI using ECG triggering. The SUV PET image pixel size was percent variation was calculated anterior wall (ANT), septal wall (SEP), inferior wall (INF) and lateral wall (LAT) in polar map. Homogeneity was calculated no corrected PET (NC), attenuation corrected PET with CT image (AC-CT) and AC gated PET with gated CT image (gAC-gCT). TTC staining measures tissue viability used to evaluate real infarct size. The reference infarct size was defined by infarction area percentage of the total left myocardium. The infarct size for optimal size was repeated varying threshold values. The NC and AC-CT image percent variation of ANT, SEP, INF and LAT was 0.42%, 1.61%, 0.41% and 0.86% respectively. The gAC-gCT image percent variation of ANT, SEP, INF and LAT was 3.74% 1.21% 3.28% and 4.29% respectively. The gated CT AC gated PET polar map homogeneity was improved myocardial activity in anterior, inferior and lateral region. MRI based polar map with FLASH sequence at threshold lower 60% provide good result of infarct size measurement. Integrated myocardial analysis technology of high sensitive PET and high resolution MRI images may potentially facilitate the improvement of volume and attenuation correction information in cardiology.

Original language	English
Title of host publication	IEEE Nuclear Science Symposuim and Medical Imaging Conference, NSS/MIC 2010
Pages	2710-2713
Number of pages	4
DOIs	https://doi.org/10.1109/NSSMIC.2010.5874283
State	Published - 2010
Event	2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010 - Knoxville, TN, United States Duration: 30 Oct 2010 → 6 Nov 2010

Publication series

Name	IEEE Nuclear Science Symposium Conference Record
ISSN (Print)	1095-7863

Conference

Conference	2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010
Country/Territory	United States
City	Knoxville, TN
Period	30/10/10 → 6/11/10

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10.1109/NSSMIC.2010.5874283

Cite this

Woo, S. K., Cheon, G. J., Kim, K. M., Lee, W. H., Lee, Y. J., Kim, M. H., Kang, J. H., Ji, Y. H., Choi, C. W., & Lim, S. M. (2010). Development of assessment technology for a rat myocardial infarct model using integrated PET/CT and MRI images. In IEEE Nuclear Science Symposuim and Medical Imaging Conference, NSS/MIC 2010 (pp. 2710-2713). Article 5874283 (IEEE Nuclear Science Symposium Conference Record). https://doi.org/10.1109/NSSMIC.2010.5874283

@inproceedings{8aba92cc94394b809b87e3e80d8b89a5,

title = "Development of assessment technology for a rat myocardial infarct model using integrated PET/CT and MRI images",

abstract = "The aim of this study was to improve quantitative assessment of rat myocardial infarct size using attenuation corrected PET polar map with gated CT image and MRI polarmap. The PET/CT images obtained with a small animal PET/CT scanner. Gating was realized with the help of an external trigger device. Contrast enhanced FLASH sequence MRI image was acquired with a 3-T clinical MRI using ECG triggering. The SUV PET image pixel size was percent variation was calculated anterior wall (ANT), septal wall (SEP), inferior wall (INF) and lateral wall (LAT) in polar map. Homogeneity was calculated no corrected PET (NC), attenuation corrected PET with CT image (AC-CT) and AC gated PET with gated CT image (gAC-gCT). TTC staining measures tissue viability used to evaluate real infarct size. The reference infarct size was defined by infarction area percentage of the total left myocardium. The infarct size for optimal size was repeated varying threshold values. The NC and AC-CT image percent variation of ANT, SEP, INF and LAT was 0.42\%, 1.61\%, 0.41\% and 0.86\% respectively. The gAC-gCT image percent variation of ANT, SEP, INF and LAT was 3.74\% 1.21\% 3.28\% and 4.29\% respectively. The gated CT AC gated PET polar map homogeneity was improved myocardial activity in anterior, inferior and lateral region. MRI based polar map with FLASH sequence at threshold lower 60\% provide good result of infarct size measurement. Integrated myocardial analysis technology of high sensitive PET and high resolution MRI images may potentially facilitate the improvement of volume and attenuation correction information in cardiology.",

author = "Woo, \{Sang Keun\} and Cheon, \{Gi Jeong\} and Kim, \{Kyeong Min\} and Lee, \{Won Ho\} and Lee, \{Yong Jin\} and Kim, \{Min Hwan\} and Kang, \{Joo Hyun\} and Ji, \{Young Hoon\} and Choi, \{Chang Woon\} and Lim, \{Sang Moo\}",

year = "2010",

doi = "10.1109/NSSMIC.2010.5874283",

language = "English",

isbn = "9781424491063",

series = "IEEE Nuclear Science Symposium Conference Record",

pages = "2710--2713",

booktitle = "IEEE Nuclear Science Symposuim and Medical Imaging Conference, NSS/MIC 2010",

note = "2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010 ; Conference date: 30-10-2010 Through 06-11-2010",

}

Woo, SK, Cheon, GJ, Kim, KM, Lee, WH, Lee, YJ, Kim, MH, Kang, JH, Ji, YH, Choi, CW & Lim, SM 2010, Development of assessment technology for a rat myocardial infarct model using integrated PET/CT and MRI images. in IEEE Nuclear Science Symposuim and Medical Imaging Conference, NSS/MIC 2010., 5874283, IEEE Nuclear Science Symposium Conference Record, pp. 2710-2713, 2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010, Knoxville, TN, United States, 30/10/10. https://doi.org/10.1109/NSSMIC.2010.5874283

Development of assessment technology for a rat myocardial infarct model using integrated PET/CT and MRI images. / Woo, Sang Keun; Cheon, Gi Jeong; Kim, Kyeong Min et al.
IEEE Nuclear Science Symposuim and Medical Imaging Conference, NSS/MIC 2010. 2010. p. 2710-2713 5874283 (IEEE Nuclear Science Symposium Conference Record).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Development of assessment technology for a rat myocardial infarct model using integrated PET/CT and MRI images

AU - Woo, Sang Keun

AU - Cheon, Gi Jeong

AU - Kim, Kyeong Min

AU - Lee, Won Ho

AU - Lee, Yong Jin

AU - Kim, Min Hwan

AU - Kang, Joo Hyun

AU - Ji, Young Hoon

AU - Choi, Chang Woon

AU - Lim, Sang Moo

PY - 2010

Y1 - 2010

N2 - The aim of this study was to improve quantitative assessment of rat myocardial infarct size using attenuation corrected PET polar map with gated CT image and MRI polarmap. The PET/CT images obtained with a small animal PET/CT scanner. Gating was realized with the help of an external trigger device. Contrast enhanced FLASH sequence MRI image was acquired with a 3-T clinical MRI using ECG triggering. The SUV PET image pixel size was percent variation was calculated anterior wall (ANT), septal wall (SEP), inferior wall (INF) and lateral wall (LAT) in polar map. Homogeneity was calculated no corrected PET (NC), attenuation corrected PET with CT image (AC-CT) and AC gated PET with gated CT image (gAC-gCT). TTC staining measures tissue viability used to evaluate real infarct size. The reference infarct size was defined by infarction area percentage of the total left myocardium. The infarct size for optimal size was repeated varying threshold values. The NC and AC-CT image percent variation of ANT, SEP, INF and LAT was 0.42%, 1.61%, 0.41% and 0.86% respectively. The gAC-gCT image percent variation of ANT, SEP, INF and LAT was 3.74% 1.21% 3.28% and 4.29% respectively. The gated CT AC gated PET polar map homogeneity was improved myocardial activity in anterior, inferior and lateral region. MRI based polar map with FLASH sequence at threshold lower 60% provide good result of infarct size measurement. Integrated myocardial analysis technology of high sensitive PET and high resolution MRI images may potentially facilitate the improvement of volume and attenuation correction information in cardiology.

AB - The aim of this study was to improve quantitative assessment of rat myocardial infarct size using attenuation corrected PET polar map with gated CT image and MRI polarmap. The PET/CT images obtained with a small animal PET/CT scanner. Gating was realized with the help of an external trigger device. Contrast enhanced FLASH sequence MRI image was acquired with a 3-T clinical MRI using ECG triggering. The SUV PET image pixel size was percent variation was calculated anterior wall (ANT), septal wall (SEP), inferior wall (INF) and lateral wall (LAT) in polar map. Homogeneity was calculated no corrected PET (NC), attenuation corrected PET with CT image (AC-CT) and AC gated PET with gated CT image (gAC-gCT). TTC staining measures tissue viability used to evaluate real infarct size. The reference infarct size was defined by infarction area percentage of the total left myocardium. The infarct size for optimal size was repeated varying threshold values. The NC and AC-CT image percent variation of ANT, SEP, INF and LAT was 0.42%, 1.61%, 0.41% and 0.86% respectively. The gAC-gCT image percent variation of ANT, SEP, INF and LAT was 3.74% 1.21% 3.28% and 4.29% respectively. The gated CT AC gated PET polar map homogeneity was improved myocardial activity in anterior, inferior and lateral region. MRI based polar map with FLASH sequence at threshold lower 60% provide good result of infarct size measurement. Integrated myocardial analysis technology of high sensitive PET and high resolution MRI images may potentially facilitate the improvement of volume and attenuation correction information in cardiology.

UR - https://www.scopus.com/pages/publications/79960327715

U2 - 10.1109/NSSMIC.2010.5874283

DO - 10.1109/NSSMIC.2010.5874283

M3 - Conference contribution

AN - SCOPUS:79960327715

SN - 9781424491063

T3 - IEEE Nuclear Science Symposium Conference Record

SP - 2710

EP - 2713

BT - IEEE Nuclear Science Symposuim and Medical Imaging Conference, NSS/MIC 2010

T2 - 2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010

Y2 - 30 October 2010 through 6 November 2010

ER -

Development of assessment technology for a rat myocardial infarct model using integrated PET/CT and MRI images

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