TY - GEN
T1 - Development of continuous cell lysis and separation device using repulsive force generated by ion concentration polarization
AU - Jeon, Hyungkook
AU - Lim, Geunbae
N1 - Publisher Copyright:
© 14CBMS.
PY - 2014
Y1 - 2014
N2 - In this paper, we report a novel continuous cell lysis and separation device using the electrical repulsion in the depletion region formed by ion concentration polarization (ICP). In the depletion region, strong electrophoretic force is applied to charged materials due to the concentrated electric field. Using the strong electrophoretic force, we lysed cells and separated molecule dyes whose size range is order of 1 nm in the same device. Therefore, the developed multifunctional microfluidic chip is expected to be a very useful tool as an integrated system for analyzing biomolecules in cells such as DNAs and proteins.
AB - In this paper, we report a novel continuous cell lysis and separation device using the electrical repulsion in the depletion region formed by ion concentration polarization (ICP). In the depletion region, strong electrophoretic force is applied to charged materials due to the concentrated electric field. Using the strong electrophoretic force, we lysed cells and separated molecule dyes whose size range is order of 1 nm in the same device. Therefore, the developed multifunctional microfluidic chip is expected to be a very useful tool as an integrated system for analyzing biomolecules in cells such as DNAs and proteins.
KW - Cell lysis
KW - Integrated analysis system
KW - Ion concentration polarization
KW - Separation
UR - https://www.scopus.com/pages/publications/84941670179
M3 - Conference contribution
AN - SCOPUS:84941670179
T3 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
SP - 2459
EP - 2461
BT - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PB - Chemical and Biological Microsystems Society
T2 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Y2 - 26 October 2014 through 30 October 2014
ER -