Development of label-free biosensor based on aptamer- Modified si nanowire field effect transistor (FET) using top-down approach and sol-gel method

J. H. Lee; J. H. Roh; K. S. Shin; D. S. Lee; J. A. Lee; S. Y. Kim; Y. H. Cho

Development of label-free biosensor based on aptamer- Modified si nanowire field effect transistor (FET) using top-down approach and sol-gel method

J. H. Lee
, J. H. Roh
, K. S. Shin
, D. S. Lee
, J. A. Lee
, S. Y. Kim
, Y. H. Cho

Dept. of Mechanical System and Design Engineering

Seoul National University of Science and Technology (SNUST)
Korea Electronics Technology Institute
PCL Inc
Dongguk University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

In this study, Si-NWs with the length of 200 jim, width of 200 nm, and height of 50 nm were fabricated using basic MEMS processes such as photolithography, RIE and KOH etching. They had high sensitivity and showed the FET characteristics due to high surface-to-volume ratio. Also, high affinity aptamers for prostate specific antigen (PSA) were immobilized on Si-NW using sol-gel method and then the real-time measurement of electrical signal of free-PSA and total-PSA which was guideline of prostate cancer was carried out according to PSA concentration.

Original language	English
Title of host publication	17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
Publisher	Chemical and Biological Microsystems Society
Pages	206-208
Number of pages	3
ISBN (Print)	9781632666246
State	Published - 2013
Event	17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 - Freiburg, Germany Duration: 27 Oct 2013 → 31 Oct 2013

Publication series

Name	17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
Volume	1

Conference

Conference	17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
Country/Territory	Germany
City	Freiburg
Period	27/10/13 → 31/10/13

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Aptamer
Field effect transistor (FET)
Prostate specific antigen (psa)
Silicon nanowire (Si-NW)
Sol-gel

Cite this

Lee, J. H., Roh, J. H., Shin, K. S., Lee, D. S., Lee, J. A., Kim, S. Y., & Cho, Y. H. (2013). Development of label-free biosensor based on aptamer- Modified si nanowire field effect transistor (FET) using top-down approach and sol-gel method. In 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 (pp. 206-208). (17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013; Vol. 1). Chemical and Biological Microsystems Society.

Lee, J. H. ; Roh, J. H. ; Shin, K. S. et al. / Development of label-free biosensor based on aptamer- Modified si nanowire field effect transistor (FET) using top-down approach and sol-gel method. 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. Chemical and Biological Microsystems Society, 2013. pp. 206-208 (17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013).

@inproceedings{210aff69946b47488bd9225cc3c64efd,

title = "Development of label-free biosensor based on aptamer- Modified si nanowire field effect transistor (FET) using top-down approach and sol-gel method",

abstract = "In this study, Si-NWs with the length of 200 jim, width of 200 nm, and height of 50 nm were fabricated using basic MEMS processes such as photolithography, RIE and KOH etching. They had high sensitivity and showed the FET characteristics due to high surface-to-volume ratio. Also, high affinity aptamers for prostate specific antigen (PSA) were immobilized on Si-NW using sol-gel method and then the real-time measurement of electrical signal of free-PSA and total-PSA which was guideline of prostate cancer was carried out according to PSA concentration.",

keywords = "Aptamer, Field effect transistor (FET), Prostate specific antigen (psa), Silicon nanowire (Si-NW), Sol-gel",

author = "Lee, \{J. H.\} and Roh, \{J. H.\} and Shin, \{K. S.\} and Lee, \{D. S.\} and Lee, \{J. A.\} and Kim, \{S. Y.\} and Cho, \{Y. H.\}",

year = "2013",

language = "English",

isbn = "9781632666246",

series = "17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013",

publisher = "Chemical and Biological Microsystems Society",

pages = "206--208",

booktitle = "17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013",

note = "17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 ; Conference date: 27-10-2013 Through 31-10-2013",

}

Lee, JH, Roh, JH, Shin, KS, Lee, DS, Lee, JA, Kim, SY & Cho, YH 2013, Development of label-free biosensor based on aptamer- Modified si nanowire field effect transistor (FET) using top-down approach and sol-gel method. in 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013, vol. 1, Chemical and Biological Microsystems Society, pp. 206-208, 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013, Freiburg, Germany, 27/10/13.

Development of label-free biosensor based on aptamer- Modified si nanowire field effect transistor (FET) using top-down approach and sol-gel method. / Lee, J. H.; Roh, J. H.; Shin, K. S. et al.
17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. Chemical and Biological Microsystems Society, 2013. p. 206-208 (17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013; Vol. 1).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Development of label-free biosensor based on aptamer- Modified si nanowire field effect transistor (FET) using top-down approach and sol-gel method

AU - Lee, J. H.

AU - Roh, J. H.

AU - Shin, K. S.

AU - Lee, D. S.

AU - Lee, J. A.

AU - Kim, S. Y.

AU - Cho, Y. H.

PY - 2013

Y1 - 2013

N2 - In this study, Si-NWs with the length of 200 jim, width of 200 nm, and height of 50 nm were fabricated using basic MEMS processes such as photolithography, RIE and KOH etching. They had high sensitivity and showed the FET characteristics due to high surface-to-volume ratio. Also, high affinity aptamers for prostate specific antigen (PSA) were immobilized on Si-NW using sol-gel method and then the real-time measurement of electrical signal of free-PSA and total-PSA which was guideline of prostate cancer was carried out according to PSA concentration.

AB - In this study, Si-NWs with the length of 200 jim, width of 200 nm, and height of 50 nm were fabricated using basic MEMS processes such as photolithography, RIE and KOH etching. They had high sensitivity and showed the FET characteristics due to high surface-to-volume ratio. Also, high affinity aptamers for prostate specific antigen (PSA) were immobilized on Si-NW using sol-gel method and then the real-time measurement of electrical signal of free-PSA and total-PSA which was guideline of prostate cancer was carried out according to PSA concentration.

KW - Aptamer

KW - Field effect transistor (FET)

KW - Prostate specific antigen (psa)

KW - Silicon nanowire (Si-NW)

KW - Sol-gel

UR - https://www.scopus.com/pages/publications/84907355395

M3 - Conference contribution

AN - SCOPUS:84907355395

SN - 9781632666246

T3 - 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013

SP - 206

EP - 208

BT - 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013

PB - Chemical and Biological Microsystems Society

T2 - 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013

Y2 - 27 October 2013 through 31 October 2013

ER -

Lee JH, Roh JH, Shin KS, Lee DS, Lee JA, Kim SY et al. Development of label-free biosensor based on aptamer- Modified si nanowire field effect transistor (FET) using top-down approach and sol-gel method. In 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. Chemical and Biological Microsystems Society. 2013. p. 206-208. (17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013).

Development of label-free biosensor based on aptamer- Modified si nanowire field effect transistor (FET) using top-down approach and sol-gel method

Abstract

Publication series

Conference

UN SDGs

Keywords

Other files and links

Fingerprint

Cite this