Development of label-free biosensor based on aptamer- Modified si nanowire field effect transistor (FET) using top-down approach and sol-gel method

J. H. Lee, J. H. Roh, K. S. Shin, D. S. Lee, J. A. Lee, S. Y. Kim, Y. H. Cho

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

In this study, Si-NWs with the length of 200 jim, width of 200 nm, and height of 50 nm were fabricated using basic MEMS processes such as photolithography, RIE and KOH etching. They had high sensitivity and showed the FET characteristics due to high surface-to-volume ratio. Also, high affinity aptamers for prostate specific antigen (PSA) were immobilized on Si-NW using sol-gel method and then the real-time measurement of electrical signal of free-PSA and total-PSA which was guideline of prostate cancer was carried out according to PSA concentration.

Original languageEnglish
Title of host publication17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
PublisherChemical and Biological Microsystems Society
Pages206-208
Number of pages3
ISBN (Print)9781632666246
StatePublished - 2013
Event17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 - Freiburg, Germany
Duration: 27 Oct 201331 Oct 2013

Publication series

Name17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
Volume1

Conference

Conference17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
Country/TerritoryGermany
CityFreiburg
Period27/10/1331/10/13

Keywords

  • Aptamer
  • Field effect transistor (FET)
  • Prostate specific antigen (psa)
  • Silicon nanowire (Si-NW)
  • Sol-gel

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