Abstract
The effect of cerivastatin (CER) on the permeability of lipid-raft-mimetic membrane was
investigated. CER is a drug candidate to treat dyslipidemia and cardiovascular diseases.
Sphingomyelin (SM) was used to form the outer layer of liposomes of which inner layer was
prepared with dioleoylphosphatidic-acid. The permeability of the SM layer was estimated by
measuring the release of the pyranine encapsulated in the liposome. The change of the
permeability was analyzed with the presence of CER dispersion in PBS buffer, especially its
hydrophobic group. The results of this study seem to be useful in deriving the drug candidate for
cardiovascular disease.
investigated. CER is a drug candidate to treat dyslipidemia and cardiovascular diseases.
Sphingomyelin (SM) was used to form the outer layer of liposomes of which inner layer was
prepared with dioleoylphosphatidic-acid. The permeability of the SM layer was estimated by
measuring the release of the pyranine encapsulated in the liposome. The change of the
permeability was analyzed with the presence of CER dispersion in PBS buffer, especially its
hydrophobic group. The results of this study seem to be useful in deriving the drug candidate for
cardiovascular disease.
| Original language | English |
|---|---|
| Article number | BN.1369 |
| Pages (from-to) | 1-5 |
| Number of pages | 5 |
| Journal | Bionature |
| Volume | 43 |
| Issue number | 2 |
| DOIs | |
| State | Published - Sep 2023 |