Effects of ATP on TTX-sensitive and TTX-resistant sodium currents in rat sensory neurons

Jin Ho Song; Yong Kyoo Shin; Chung Soo Lee; Hyoweon Bang; Mijung Park

doi:10.1097/00001756-200112040-00011

Effects of ATP on TTX-sensitive and TTX-resistant sodium currents in rat sensory neurons

Jin Ho Song, Yong Kyoo Shin, Chung Soo Lee, Hyoweon Bang, Mijung Park

Dept. of Optometry

Chung-Ang University

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Differential effects of ATP on tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) sodium currents in ratat dorsal root ganglion neurons were studied using the whole-cell variation of path-clamp technique. Currents were evoked by step depolarizations to 0mV from a holding potential of -80mV. ATP suppressed TTX-S sodium currents while it increased TTX-R sodium currents. The effects were concentration-dependent and were reversible upon washout with ATP-free external solution. ATP-γ-S, a hydrolysis-resistant ATP analog, also affected two types of sodium currents similarly to ATP, excluding the possibility that the effects were caused by the products of ATP hydrolysis, namely adenosine. ATP by modulating sodium currents may exert profound effects on the transmission of sensory information such as nociception.

Original language	English
Pages (from-to)	3659-3662
Number of pages	4
Journal	NeuroReport
Volume	12
Issue number	17
DOIs	https://doi.org/10.1097/00001756-200112040-00011
State	Published - 4 Dec 2001

Keywords

ATP
Dorsal root ganglion
Pain
Sodium current
Tetrodotoxin

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10.1097/00001756-200112040-00011

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title = "Effects of ATP on TTX-sensitive and TTX-resistant sodium currents in rat sensory neurons",

abstract = "Differential effects of ATP on tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) sodium currents in ratat dorsal root ganglion neurons were studied using the whole-cell variation of path-clamp technique. Currents were evoked by step depolarizations to 0mV from a holding potential of -80mV. ATP suppressed TTX-S sodium currents while it increased TTX-R sodium currents. The effects were concentration-dependent and were reversible upon washout with ATP-free external solution. ATP-γ-S, a hydrolysis-resistant ATP analog, also affected two types of sodium currents similarly to ATP, excluding the possibility that the effects were caused by the products of ATP hydrolysis, namely adenosine. ATP by modulating sodium currents may exert profound effects on the transmission of sensory information such as nociception.",

keywords = "ATP, Dorsal root ganglion, Pain, Sodium current, Tetrodotoxin",

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AU - Song, Jin Ho

AU - Shin, Yong Kyoo

AU - Lee, Chung Soo

AU - Bang, Hyoweon

AU - Park, Mijung

PY - 2001/12/4

Y1 - 2001/12/4

N2 - Differential effects of ATP on tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) sodium currents in ratat dorsal root ganglion neurons were studied using the whole-cell variation of path-clamp technique. Currents were evoked by step depolarizations to 0mV from a holding potential of -80mV. ATP suppressed TTX-S sodium currents while it increased TTX-R sodium currents. The effects were concentration-dependent and were reversible upon washout with ATP-free external solution. ATP-γ-S, a hydrolysis-resistant ATP analog, also affected two types of sodium currents similarly to ATP, excluding the possibility that the effects were caused by the products of ATP hydrolysis, namely adenosine. ATP by modulating sodium currents may exert profound effects on the transmission of sensory information such as nociception.

AB - Differential effects of ATP on tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) sodium currents in ratat dorsal root ganglion neurons were studied using the whole-cell variation of path-clamp technique. Currents were evoked by step depolarizations to 0mV from a holding potential of -80mV. ATP suppressed TTX-S sodium currents while it increased TTX-R sodium currents. The effects were concentration-dependent and were reversible upon washout with ATP-free external solution. ATP-γ-S, a hydrolysis-resistant ATP analog, also affected two types of sodium currents similarly to ATP, excluding the possibility that the effects were caused by the products of ATP hydrolysis, namely adenosine. ATP by modulating sodium currents may exert profound effects on the transmission of sensory information such as nociception.

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Effects of ATP on TTX-sensitive and TTX-resistant sodium currents in rat sensory neurons

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