Effects of lysophosphatidic acid on sodium currents in rat dorsal root ganglion neurons

Woo Seung Lee; Min Pyo Hong; Tae Hoon Kim; Yong Kyoo Shin; Chung Soo Lee; Mijung Park; Jin Ho Song

doi:10.1016/j.brainres.2004.12.026

Effects of lysophosphatidic acid on sodium currents in rat dorsal root ganglion neurons

Woo Seung Lee, Min Pyo Hong, Tae Hoon Kim, Yong Kyoo Shin, Chung Soo Lee, Mijung Park, Jin Ho Song

Dept. of Optometry

Chung-Ang University

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Lysophosphatidic acid (LPA), a simple phospholipid, induces pain. To elucidate an involvement of ion channel mechanism in the LPA-induced pain, its effects on sodium currents in rat dorsal root ganglion (DRG) neurons were investigated. LPA suppressed tetrodotoxin-sensitive (TTX-S) sodium current, but increased tetrodotoxin-resistant (TTX-R) sodium current, when currents were evoked by step depolarizations to 0 mV from a holding potential of -80 mV. In both types of currents, LPA produced a hyperpolarizing shift of both activation and inactivation voltages. LPA had a negligible effect on the maximal conductance of TTX-S current, but increased that of TTX-R current. The results suggest that the enhancement of TTX-R current may contribute to the LPA-induced pain.

Original language	English
Pages (from-to)	100-104
Number of pages	5
Journal	Brain Research
Volume	1035
Issue number	1
DOIs	https://doi.org/10.1016/j.brainres.2004.12.026
State	Published - 21 Feb 2005

Keywords

Dorsal root ganglion
Lysophosphatidic acid
Sodium current
Tetrodotoxin-resistant
Tetrodotoxin-sensitive

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10.1016/j.brainres.2004.12.026

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title = "Effects of lysophosphatidic acid on sodium currents in rat dorsal root ganglion neurons",

abstract = "Lysophosphatidic acid (LPA), a simple phospholipid, induces pain. To elucidate an involvement of ion channel mechanism in the LPA-induced pain, its effects on sodium currents in rat dorsal root ganglion (DRG) neurons were investigated. LPA suppressed tetrodotoxin-sensitive (TTX-S) sodium current, but increased tetrodotoxin-resistant (TTX-R) sodium current, when currents were evoked by step depolarizations to 0 mV from a holding potential of -80 mV. In both types of currents, LPA produced a hyperpolarizing shift of both activation and inactivation voltages. LPA had a negligible effect on the maximal conductance of TTX-S current, but increased that of TTX-R current. The results suggest that the enhancement of TTX-R current may contribute to the LPA-induced pain.",

keywords = "Dorsal root ganglion, Lysophosphatidic acid, Sodium current, Tetrodotoxin-resistant, Tetrodotoxin-sensitive",

author = "Lee, \{Woo Seung\} and Hong, \{Min Pyo\} and Kim, \{Tae Hoon\} and Shin, \{Yong Kyoo\} and Lee, \{Chung Soo\} and Mijung Park and Song, \{Jin Ho\}",

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AU - Lee, Woo Seung

AU - Hong, Min Pyo

AU - Kim, Tae Hoon

AU - Shin, Yong Kyoo

AU - Lee, Chung Soo

AU - Park, Mijung

AU - Song, Jin Ho

PY - 2005/2/21

Y1 - 2005/2/21

N2 - Lysophosphatidic acid (LPA), a simple phospholipid, induces pain. To elucidate an involvement of ion channel mechanism in the LPA-induced pain, its effects on sodium currents in rat dorsal root ganglion (DRG) neurons were investigated. LPA suppressed tetrodotoxin-sensitive (TTX-S) sodium current, but increased tetrodotoxin-resistant (TTX-R) sodium current, when currents were evoked by step depolarizations to 0 mV from a holding potential of -80 mV. In both types of currents, LPA produced a hyperpolarizing shift of both activation and inactivation voltages. LPA had a negligible effect on the maximal conductance of TTX-S current, but increased that of TTX-R current. The results suggest that the enhancement of TTX-R current may contribute to the LPA-induced pain.

AB - Lysophosphatidic acid (LPA), a simple phospholipid, induces pain. To elucidate an involvement of ion channel mechanism in the LPA-induced pain, its effects on sodium currents in rat dorsal root ganglion (DRG) neurons were investigated. LPA suppressed tetrodotoxin-sensitive (TTX-S) sodium current, but increased tetrodotoxin-resistant (TTX-R) sodium current, when currents were evoked by step depolarizations to 0 mV from a holding potential of -80 mV. In both types of currents, LPA produced a hyperpolarizing shift of both activation and inactivation voltages. LPA had a negligible effect on the maximal conductance of TTX-S current, but increased that of TTX-R current. The results suggest that the enhancement of TTX-R current may contribute to the LPA-induced pain.

KW - Dorsal root ganglion

KW - Lysophosphatidic acid

KW - Sodium current

KW - Tetrodotoxin-resistant

KW - Tetrodotoxin-sensitive

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Effects of lysophosphatidic acid on sodium currents in rat dorsal root ganglion neurons

Abstract

Keywords

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