Experimental condition and registration method for the tumor detection of lung metastasis small animal PET and CT whole body images

Sang Keun Woo; Kyung Min Kim; Taesup Lee; June Yeop Kim; Jae Ho Jung; Kwang Sun Woo; Wee Sup Jung; Joo Hyun Kang; Gi Jeong Cheon; Chang Woon Choi; Sang Moo Lim

doi:10.1109/NSSMIC.2007.4436855

Experimental condition and registration method for the tumor detection of lung metastasis small animal PET and CT whole body images

Sang Keun Woo
, Kyung Min Kim
, Taesup Lee
, June Yeop Kim
, Jae Ho Jung
, Kwang Sun Woo
, Wee Sup Jung
, Joo Hyun Kang
, Gi Jeong Cheon
, Chang Woon Choi
, Sang Moo Lim

Dept. of Biomedical Sciences

Korea Institute of Radiological and Medical Sciences

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

4 Scopus citations

Abstract

Small animal PET scanning with ¹⁸F-FDG is increasingly used in murine tumor model. Experimental condition of animal handling impacts on the biodistribution of ¹⁸F-FDG in mouse study. The aim of this study was to optimize experimental conditions of animal handling and registration method for imaging lung metastasis tumor by using ¹⁸F-FDG small animal PET and CT. The experimental conditions for ¹⁸F-FDG biodistribution and animal PET imaging were 20 ± 2 h fasting and warming kept at 30°C. Biodistribution, standard uptake value (SUV) image and glucose SUV (SUV _G) of ¹⁸F-FDG were evaluated and blood glucose level was also measured. Female C57BL/6 mice were injected intravenously with 2 × 10⁵ of B16-F10 melanoma cells which developed metastasis rumors in lung. In lung metastasis tumor model, ¹⁸F-FDG images was obtained in optimized anesthesia condition and registered with anatomical clinical CT image. The small animal PET and CT images were registered using the hardware fiducial markers and small animal contour point in both data sets to perform a point-based rigid registration. Isoflurane 0.5 condition was chosen for lung metastasis tumor imaging. Lung metastasis tumor was clearly visualized by ¹⁸F-FDG PET image with Iso 0.5 anesthesia. Tumor imaging in lung region with ¹⁸F-FDG small animal PET should be considered feeding, temperature, and especially choice and level of anesthetic for minimizing background radioactivity. Fused imaging with small animal PET and CT image could be useful for the detection of metastatic tumor. This method improves the quantitative accuracy and interpretation of the tracer.

Original language	English
Title of host publication	2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC
Pages	3372-3375
Number of pages	4
DOIs	https://doi.org/10.1109/NSSMIC.2007.4436855
State	Published - 2007
Event	2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC - Honolulu, HI, United States Duration: 27 Oct 2007 → 3 Nov 2007

Publication series

Name	IEEE Nuclear Science Symposium Conference Record
Volume	5
ISSN (Print)	1095-7863

Conference

Conference	2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC
Country/Territory	United States
City	Honolulu, HI
Period	27/10/07 → 3/11/07

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 7 Affordable and Clean Energy
SDG 9 Industry, Innovation, and Infrastructure
SDG 12 Responsible Consumption and Production

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10.1109/NSSMIC.2007.4436855

Cite this

Woo, S. K., Kim, K. M., Lee, T., Kim, J. Y., Jung, J. H., Woo, K. S., Jung, W. S., Kang, J. H., Cheon, G. J., Choi, C. W., & Lim, S. M. (2007). Experimental condition and registration method for the tumor detection of lung metastasis small animal PET and CT whole body images. In 2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC (pp. 3372-3375). Article 4436855 (IEEE Nuclear Science Symposium Conference Record; Vol. 5). https://doi.org/10.1109/NSSMIC.2007.4436855

@inproceedings{80c151d113244765aed9f338d1ef3e08,

title = "Experimental condition and registration method for the tumor detection of lung metastasis small animal PET and CT whole body images",

abstract = "Small animal PET scanning with 18F-FDG is increasingly used in murine tumor model. Experimental condition of animal handling impacts on the biodistribution of 18F-FDG in mouse study. The aim of this study was to optimize experimental conditions of animal handling and registration method for imaging lung metastasis tumor by using 18F-FDG small animal PET and CT. The experimental conditions for 18F-FDG biodistribution and animal PET imaging were 20 ± 2 h fasting and warming kept at 30°C. Biodistribution, standard uptake value (SUV) image and glucose SUV (SUV G) of 18F-FDG were evaluated and blood glucose level was also measured. Female C57BL/6 mice were injected intravenously with 2 × 105 of B16-F10 melanoma cells which developed metastasis rumors in lung. In lung metastasis tumor model, 18F-FDG images was obtained in optimized anesthesia condition and registered with anatomical clinical CT image. The small animal PET and CT images were registered using the hardware fiducial markers and small animal contour point in both data sets to perform a point-based rigid registration. Isoflurane 0.5 condition was chosen for lung metastasis tumor imaging. Lung metastasis tumor was clearly visualized by 18F-FDG PET image with Iso 0.5 anesthesia. Tumor imaging in lung region with 18F-FDG small animal PET should be considered feeding, temperature, and especially choice and level of anesthetic for minimizing background radioactivity. Fused imaging with small animal PET and CT image could be useful for the detection of metastatic tumor. This method improves the quantitative accuracy and interpretation of the tracer.",

author = "Woo, \{Sang Keun\} and Kim, \{Kyung Min\} and Taesup Lee and Kim, \{June Yeop\} and Jung, \{Jae Ho\} and Woo, \{Kwang Sun\} and Jung, \{Wee Sup\} and Kang, \{Joo Hyun\} and Cheon, \{Gi Jeong\} and Choi, \{Chang Woon\} and Lim, \{Sang Moo\}",

year = "2007",

doi = "10.1109/NSSMIC.2007.4436855",

language = "English",

isbn = "1424409233",

series = "IEEE Nuclear Science Symposium Conference Record",

pages = "3372--3375",

booktitle = "2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC",

note = "2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC ; Conference date: 27-10-2007 Through 03-11-2007",

}

Woo, SK, Kim, KM, Lee, T, Kim, JY, Jung, JH, Woo, KS, Jung, WS, Kang, JH, Cheon, GJ, Choi, CW & Lim, SM 2007, Experimental condition and registration method for the tumor detection of lung metastasis small animal PET and CT whole body images. in 2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC., 4436855, IEEE Nuclear Science Symposium Conference Record, vol. 5, pp. 3372-3375, 2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC, Honolulu, HI, United States, 27/10/07. https://doi.org/10.1109/NSSMIC.2007.4436855

Experimental condition and registration method for the tumor detection of lung metastasis small animal PET and CT whole body images. / Woo, Sang Keun; Kim, Kyung Min; Lee, Taesup et al.
2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC. 2007. p. 3372-3375 4436855 (IEEE Nuclear Science Symposium Conference Record; Vol. 5).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T1 - Experimental condition and registration method for the tumor detection of lung metastasis small animal PET and CT whole body images

AU - Woo, Sang Keun

AU - Kim, Kyung Min

AU - Lee, Taesup

AU - Kim, June Yeop

AU - Jung, Jae Ho

AU - Woo, Kwang Sun

AU - Jung, Wee Sup

AU - Kang, Joo Hyun

AU - Cheon, Gi Jeong

AU - Choi, Chang Woon

AU - Lim, Sang Moo

PY - 2007

Y1 - 2007

N2 - Small animal PET scanning with 18F-FDG is increasingly used in murine tumor model. Experimental condition of animal handling impacts on the biodistribution of 18F-FDG in mouse study. The aim of this study was to optimize experimental conditions of animal handling and registration method for imaging lung metastasis tumor by using 18F-FDG small animal PET and CT. The experimental conditions for 18F-FDG biodistribution and animal PET imaging were 20 ± 2 h fasting and warming kept at 30°C. Biodistribution, standard uptake value (SUV) image and glucose SUV (SUV G) of 18F-FDG were evaluated and blood glucose level was also measured. Female C57BL/6 mice were injected intravenously with 2 × 105 of B16-F10 melanoma cells which developed metastasis rumors in lung. In lung metastasis tumor model, 18F-FDG images was obtained in optimized anesthesia condition and registered with anatomical clinical CT image. The small animal PET and CT images were registered using the hardware fiducial markers and small animal contour point in both data sets to perform a point-based rigid registration. Isoflurane 0.5 condition was chosen for lung metastasis tumor imaging. Lung metastasis tumor was clearly visualized by 18F-FDG PET image with Iso 0.5 anesthesia. Tumor imaging in lung region with 18F-FDG small animal PET should be considered feeding, temperature, and especially choice and level of anesthetic for minimizing background radioactivity. Fused imaging with small animal PET and CT image could be useful for the detection of metastatic tumor. This method improves the quantitative accuracy and interpretation of the tracer.

AB - Small animal PET scanning with 18F-FDG is increasingly used in murine tumor model. Experimental condition of animal handling impacts on the biodistribution of 18F-FDG in mouse study. The aim of this study was to optimize experimental conditions of animal handling and registration method for imaging lung metastasis tumor by using 18F-FDG small animal PET and CT. The experimental conditions for 18F-FDG biodistribution and animal PET imaging were 20 ± 2 h fasting and warming kept at 30°C. Biodistribution, standard uptake value (SUV) image and glucose SUV (SUV G) of 18F-FDG were evaluated and blood glucose level was also measured. Female C57BL/6 mice were injected intravenously with 2 × 105 of B16-F10 melanoma cells which developed metastasis rumors in lung. In lung metastasis tumor model, 18F-FDG images was obtained in optimized anesthesia condition and registered with anatomical clinical CT image. The small animal PET and CT images were registered using the hardware fiducial markers and small animal contour point in both data sets to perform a point-based rigid registration. Isoflurane 0.5 condition was chosen for lung metastasis tumor imaging. Lung metastasis tumor was clearly visualized by 18F-FDG PET image with Iso 0.5 anesthesia. Tumor imaging in lung region with 18F-FDG small animal PET should be considered feeding, temperature, and especially choice and level of anesthetic for minimizing background radioactivity. Fused imaging with small animal PET and CT image could be useful for the detection of metastatic tumor. This method improves the quantitative accuracy and interpretation of the tracer.

UR - https://www.scopus.com/pages/publications/48349099567

U2 - 10.1109/NSSMIC.2007.4436855

DO - 10.1109/NSSMIC.2007.4436855

M3 - Conference contribution

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SN - 1424409233

SN - 9781424409235

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BT - 2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC

T2 - 2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC

Y2 - 27 October 2007 through 3 November 2007

ER -

Woo SK, Kim KM, Lee T, Kim JY, Jung JH, Woo KS et al. Experimental condition and registration method for the tumor detection of lung metastasis small animal PET and CT whole body images. In 2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC. 2007. p. 3372-3375. 4436855. (IEEE Nuclear Science Symposium Conference Record). doi: 10.1109/NSSMIC.2007.4436855

Experimental condition and registration method for the tumor detection of lung metastasis small animal PET and CT whole body images

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