Fluorescent determination of zinc by a quinoline-based chemosensor in aqueous media and zebrafish

Ju Byeong Chae; Dongju Yun; Sehoon Kim; Hyojin Lee; Mingeun Kim; Mi Hee Lim; Ki Tae Kim; Cheal Kim

doi:10.1016/j.saa.2019.04.044

Fluorescent determination of zinc by a quinoline-based chemosensor in aqueous media and zebrafish

Ju Byeong Chae
, Dongju Yun
, Sehoon Kim
, Hyojin Lee
, Mingeun Kim
, Mi Hee Lim
, Ki Tae Kim
, Cheal Kim

Seoul National University of Science and Technology (SNUST)
Korea Advanced Institute of Science and Technology

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

A quinoline-based fluorescence sensor QDTD was developed for Zn ²⁺ . QDTD can detect Zn ²⁺ by fluorescence turn-on. Detecting limit (0.27 μM) of QDTD for Zn ²⁺ was far below WHO standard (76.0 μM). For the practical application, compound QDTD could be used to determine Zn ²⁺ in real samples and applied to the test kit. More importantly, QDTD was expertly applied for Zn ²⁺ imaging in HeLa cells and zebrafish with good membrane-permeability. Detection mechanism of Zn ²⁺ ion by compound QDTD was suggested through the analytical tools like ¹ H NMR titration, ESI-MS, Job plot, fluorescent and UV–vis titration, and theoretical calculations, and through the synthesis and applications of a model compound AAQA.

Original language	English
Pages (from-to)	74-82
Number of pages	9
Journal	Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Volume	219
DOIs	https://doi.org/10.1016/j.saa.2019.04.044
State	Published - 5 Aug 2019

Keywords

Fluorescence chemosensor
Theoretical calculations
Zebrafish
Zinc ion

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10.1016/j.saa.2019.04.044

Cite this

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title = "Fluorescent determination of zinc by a quinoline-based chemosensor in aqueous media and zebrafish",

abstract = " A quinoline-based fluorescence sensor QDTD was developed for Zn 2+ . QDTD can detect Zn 2+ by fluorescence turn-on. Detecting limit (0.27 μM) of QDTD for Zn 2+ was far below WHO standard (76.0 μM). For the practical application, compound QDTD could be used to determine Zn 2+ in real samples and applied to the test kit. More importantly, QDTD was expertly applied for Zn 2+ imaging in HeLa cells and zebrafish with good membrane-permeability. Detection mechanism of Zn 2+ ion by compound QDTD was suggested through the analytical tools like 1 H NMR titration, ESI-MS, Job plot, fluorescent and UV–vis titration, and theoretical calculations, and through the synthesis and applications of a model compound AAQA.",

keywords = "Fluorescence chemosensor, Theoretical calculations, Zebrafish, Zinc ion",

author = "Chae, \{Ju Byeong\} and Dongju Yun and Sehoon Kim and Hyojin Lee and Mingeun Kim and Lim, \{Mi Hee\} and Kim, \{Ki Tae\} and Cheal Kim",

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year = "2019",

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doi = "10.1016/j.saa.2019.04.044",

language = "English",

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journal = "Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy",

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TY - JOUR

T1 - Fluorescent determination of zinc by a quinoline-based chemosensor in aqueous media and zebrafish

AU - Chae, Ju Byeong

AU - Yun, Dongju

AU - Kim, Sehoon

AU - Lee, Hyojin

AU - Kim, Mingeun

AU - Lim, Mi Hee

AU - Kim, Ki Tae

AU - Kim, Cheal

PY - 2019/8/5

Y1 - 2019/8/5

N2 - A quinoline-based fluorescence sensor QDTD was developed for Zn 2+ . QDTD can detect Zn 2+ by fluorescence turn-on. Detecting limit (0.27 μM) of QDTD for Zn 2+ was far below WHO standard (76.0 μM). For the practical application, compound QDTD could be used to determine Zn 2+ in real samples and applied to the test kit. More importantly, QDTD was expertly applied for Zn 2+ imaging in HeLa cells and zebrafish with good membrane-permeability. Detection mechanism of Zn 2+ ion by compound QDTD was suggested through the analytical tools like 1 H NMR titration, ESI-MS, Job plot, fluorescent and UV–vis titration, and theoretical calculations, and through the synthesis and applications of a model compound AAQA.

AB - A quinoline-based fluorescence sensor QDTD was developed for Zn 2+ . QDTD can detect Zn 2+ by fluorescence turn-on. Detecting limit (0.27 μM) of QDTD for Zn 2+ was far below WHO standard (76.0 μM). For the practical application, compound QDTD could be used to determine Zn 2+ in real samples and applied to the test kit. More importantly, QDTD was expertly applied for Zn 2+ imaging in HeLa cells and zebrafish with good membrane-permeability. Detection mechanism of Zn 2+ ion by compound QDTD was suggested through the analytical tools like 1 H NMR titration, ESI-MS, Job plot, fluorescent and UV–vis titration, and theoretical calculations, and through the synthesis and applications of a model compound AAQA.

KW - Fluorescence chemosensor

KW - Theoretical calculations

KW - Zebrafish

KW - Zinc ion

UR - https://www.scopus.com/pages/publications/85064539273

U2 - 10.1016/j.saa.2019.04.044

DO - 10.1016/j.saa.2019.04.044

M3 - Article

C2 - 31030049

AN - SCOPUS:85064539273

SN - 1386-1425

VL - 219

SP - 74

EP - 82

JO - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy

JF - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy

ER -

Fluorescent determination of zinc by a quinoline-based chemosensor in aqueous media and zebrafish

Abstract

Keywords

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