TY - GEN
T1 - Fully-automated and field-deployable blood separation platform using multi-dimensional double spiral (MDDS) inertial microfluidics
AU - Jeon, Hyungkook
AU - Han, Jongyoon
N1 - Publisher Copyright:
© 2020 CBMS-0001
PY - 2020
Y1 - 2020
N2 - Here, we developed a fully-automated and field-deployable sample separation platform based on a new type of spiral inertial microfluidic device, multi-dimensional double spiral (MDDS) device, and the check-valve-based recirculation method. Benefitting from enhanced separation performance of the MDDS device and advantages of the recirculation method, efficient leukocyte separation was achieved from microliter quantities of blood (50 μL) in a fully-automated and rapid manner without any cell damage. In addition, the platform can be operated by hand-power, which renders it readily field-deployable. Furthermore, we designed a solid plastic version (in lieu of PDMS) of the MDDS device to increase reliability and manufacturability.
AB - Here, we developed a fully-automated and field-deployable sample separation platform based on a new type of spiral inertial microfluidic device, multi-dimensional double spiral (MDDS) device, and the check-valve-based recirculation method. Benefitting from enhanced separation performance of the MDDS device and advantages of the recirculation method, efficient leukocyte separation was achieved from microliter quantities of blood (50 μL) in a fully-automated and rapid manner without any cell damage. In addition, the platform can be operated by hand-power, which renders it readily field-deployable. Furthermore, we designed a solid plastic version (in lieu of PDMS) of the MDDS device to increase reliability and manufacturability.
KW - Field-Deployable Platform
KW - Inertial Microfluidics
KW - Leukocyte Isolation
KW - Plastic Microfluidic Device
UR - http://www.scopus.com/inward/record.url?scp=85098278528&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85098278528
T3 - MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
SP - 725
EP - 726
BT - MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PB - Chemical and Biological Microsystems Society
T2 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020
Y2 - 4 October 2020 through 9 October 2020
ER -