Highly sensitive dansyl-based chemosensor for detection of Cu2+ in aqueous solution and zebrafish

Ju Byeong Chae; Dongju Yun; Hangyul Lee; Hyojin Lee; Ki Tae Kim; Cheal Kim

doi:10.1021/acsomega.9b00970

Highly sensitive dansyl-based chemosensor for detection of Cu²⁺ in aqueous solution and zebrafish

Ju Byeong Chae, Dongju Yun, Hangyul Lee, Hyojin Lee, Ki Tae Kim, Cheal Kim

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

A new dansyl-based chemosensor (2-(4-((5-(dimethylamino)naphthalen-1-yl)sulfonyl)piperazin-1-yl)-N-(quinolin-8-yl)acetamide) (DC) for detecting Cu²⁺ was synthesized and characterized. DC showed great selectivity to Cu²⁺ by a fluorescent "on-off" detection method. Job plot, ESI-mass spectroscopy, and ¹H NMR titration suggested a 1 to 1 binding mode between DC and Cu²⁺. The detection limit was determined to be 43 nM, which is greatly below the WHO guidelines. In addition, DC can be applied to real samples and zebrafish imaging. The fluorescence quenching mechanism was proposed as the enhancement of intramolecular charge transfer with calculations.

Original language	English
Pages (from-to)	12537-12543
Number of pages	7
Journal	ACS Omega
Volume	4
Issue number	7
DOIs	https://doi.org/10.1021/acsomega.9b00970
State	Published - 24 Jul 2019

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title = "Highly sensitive dansyl-based chemosensor for detection of Cu2+ in aqueous solution and zebrafish",

abstract = "A new dansyl-based chemosensor (2-(4-((5-(dimethylamino)naphthalen-1-yl)sulfonyl)piperazin-1-yl)-N-(quinolin-8-yl)acetamide) (DC) for detecting Cu2+ was synthesized and characterized. DC showed great selectivity to Cu2+ by a fluorescent {"}on-off{"} detection method. Job plot, ESI-mass spectroscopy, and 1H NMR titration suggested a 1 to 1 binding mode between DC and Cu2+. The detection limit was determined to be 43 nM, which is greatly below the WHO guidelines. In addition, DC can be applied to real samples and zebrafish imaging. The fluorescence quenching mechanism was proposed as the enhancement of intramolecular charge transfer with calculations.",

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AU - Chae, Ju Byeong

AU - Yun, Dongju

AU - Lee, Hangyul

AU - Lee, Hyojin

AU - Kim, Ki Tae

AU - Kim, Cheal

PY - 2019/7/24

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N2 - A new dansyl-based chemosensor (2-(4-((5-(dimethylamino)naphthalen-1-yl)sulfonyl)piperazin-1-yl)-N-(quinolin-8-yl)acetamide) (DC) for detecting Cu2+ was synthesized and characterized. DC showed great selectivity to Cu2+ by a fluorescent "on-off" detection method. Job plot, ESI-mass spectroscopy, and 1H NMR titration suggested a 1 to 1 binding mode between DC and Cu2+. The detection limit was determined to be 43 nM, which is greatly below the WHO guidelines. In addition, DC can be applied to real samples and zebrafish imaging. The fluorescence quenching mechanism was proposed as the enhancement of intramolecular charge transfer with calculations.

AB - A new dansyl-based chemosensor (2-(4-((5-(dimethylamino)naphthalen-1-yl)sulfonyl)piperazin-1-yl)-N-(quinolin-8-yl)acetamide) (DC) for detecting Cu2+ was synthesized and characterized. DC showed great selectivity to Cu2+ by a fluorescent "on-off" detection method. Job plot, ESI-mass spectroscopy, and 1H NMR titration suggested a 1 to 1 binding mode between DC and Cu2+. The detection limit was determined to be 43 nM, which is greatly below the WHO guidelines. In addition, DC can be applied to real samples and zebrafish imaging. The fluorescence quenching mechanism was proposed as the enhancement of intramolecular charge transfer with calculations.

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Highly sensitive dansyl-based chemosensor for detection of Cu²⁺ in aqueous solution and zebrafish

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