Abstract
Based on our study with o-quinone generation and its adduct formation, a series of alkyl and arylcarbamate pro-drugs of vanillyl alcohol was designed, prepared and tested for their biochemical activity.
Compounds MPC-003, MPC-007 and MPC-011 inhibited melanin synthesis weakly in B16 cell. Aralkyl dicarbamate MPC-004 was active for the mushroom tyrosinase and failed to inhibit melanin synthesis in B16cell. The preparation of the other analogs based on current findings is ongoing. These carbamate pro-drugs of vanillyl alcohol may prove therapeutic as melanin synthesis inhibitors
Compounds MPC-003, MPC-007 and MPC-011 inhibited melanin synthesis weakly in B16 cell. Aralkyl dicarbamate MPC-004 was active for the mushroom tyrosinase and failed to inhibit melanin synthesis in B16cell. The preparation of the other analogs based on current findings is ongoing. These carbamate pro-drugs of vanillyl alcohol may prove therapeutic as melanin synthesis inhibitors
| Translated title of the contribution | Synthesis and Biochemical Analysis of Carbamate Pro-Drugs with Vanillyl Alcohol as Melanogenesis Inhibitors |
|---|---|
| Original language | Korean |
| Pages (from-to) | 9-16 |
| Number of pages | 8 |
| Journal | 과학수사학 |
| Volume | 5 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2011 |
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