Microphysiometric Measurement of PAF Receptor Responses to Ginkgolides

Sonja Krane; So Ra Kim; Leif M. Abrell; Koji Nakanishi

doi:10.1002/hlca.200390319

Microphysiometric Measurement of PAF Receptor Responses to Ginkgolides

Sonja Krane
, So Ra Kim
, Leif M. Abrell
, Koji Nakanishi

Dept. of Optometry

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Microphysiometry was used to evaluate the effects of terpene trilactone and flavonoid constituents of Ginkgo biloba on human platelet-activating-factor receptor (PAFR). Inhibition of the platelet-activating factor response by terpene trilactones was confirmed using this functional assay. Ginkgolide B (GB) and 10-O-benzyl-GB showed the strongest inhibition (81 and 93%, resp.) of the PAFR response, while the flavonoids rutin, quercetin, and kaempferol showed negligible response inhibition. G. biloba extract mixtures were also tested, and results indicate possible synergistic effects among various components.

Original language	English
Pages (from-to)	3776-3786
Number of pages	11
Journal	Helvetica Chimica Acta
Volume	86
Issue number	11
DOIs	https://doi.org/10.1002/hlca.200390319
State	Published - 2003

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title = "Microphysiometric Measurement of PAF Receptor Responses to Ginkgolides",

abstract = "Microphysiometry was used to evaluate the effects of terpene trilactone and flavonoid constituents of Ginkgo biloba on human platelet-activating-factor receptor (PAFR). Inhibition of the platelet-activating factor response by terpene trilactones was confirmed using this functional assay. Ginkgolide B (GB) and 10-O-benzyl-GB showed the strongest inhibition (81 and 93\%, resp.) of the PAFR response, while the flavonoids rutin, quercetin, and kaempferol showed negligible response inhibition. G. biloba extract mixtures were also tested, and results indicate possible synergistic effects among various components.",

author = "Sonja Krane and Kim, \{So Ra\} and Abrell, \{Leif M.\} and Koji Nakanishi",

year = "2003",

doi = "10.1002/hlca.200390319",

language = "English",

volume = "86",

pages = "3776--3786",

journal = "Helvetica Chimica Acta",

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T1 - Microphysiometric Measurement of PAF Receptor Responses to Ginkgolides

AU - Krane, Sonja

AU - Kim, So Ra

AU - Abrell, Leif M.

AU - Nakanishi, Koji

PY - 2003

Y1 - 2003

N2 - Microphysiometry was used to evaluate the effects of terpene trilactone and flavonoid constituents of Ginkgo biloba on human platelet-activating-factor receptor (PAFR). Inhibition of the platelet-activating factor response by terpene trilactones was confirmed using this functional assay. Ginkgolide B (GB) and 10-O-benzyl-GB showed the strongest inhibition (81 and 93%, resp.) of the PAFR response, while the flavonoids rutin, quercetin, and kaempferol showed negligible response inhibition. G. biloba extract mixtures were also tested, and results indicate possible synergistic effects among various components.

AB - Microphysiometry was used to evaluate the effects of terpene trilactone and flavonoid constituents of Ginkgo biloba on human platelet-activating-factor receptor (PAFR). Inhibition of the platelet-activating factor response by terpene trilactones was confirmed using this functional assay. Ginkgolide B (GB) and 10-O-benzyl-GB showed the strongest inhibition (81 and 93%, resp.) of the PAFR response, while the flavonoids rutin, quercetin, and kaempferol showed negligible response inhibition. G. biloba extract mixtures were also tested, and results indicate possible synergistic effects among various components.

UR - https://www.scopus.com/pages/publications/0346752023

U2 - 10.1002/hlca.200390319

DO - 10.1002/hlca.200390319

M3 - Article

AN - SCOPUS:0346752023

SN - 0018-019X

VL - 86

SP - 3776

EP - 3786

JO - Helvetica Chimica Acta

JF - Helvetica Chimica Acta

IS - 11

ER -

Microphysiometric Measurement of PAF Receptor Responses to Ginkgolides

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