TY - GEN
T1 - Nonlithographic fabrication of inflatable and deflatable polydimethylsiloxane (PDMS) micro-channels for magnetic actuation
AU - Kim, Hyun
AU - Kim, Pyojin
AU - Seo, Jong Mo
N1 - Publisher Copyright:
© 2017 IEEE.
PY - 2017/9/13
Y1 - 2017/9/13
N2 - An implantable drug delivery device with an inflatable/deflatable reservoir, a release rate controlling micro-channel, a syringe attachable inlet, a unidirectional channel preventing drug substances from flowing back into the inlet, and a magnetic polydimethylsiloxane (PDMS) outlet capable of on-demand drug release was designed and fabricated to realize effective drug therapy. The reservoir is refillable through the inlet. Therefore, the device is reusable. The device does not employ photolithography patterning. Vapor coating, a precise cutting plotter, a vinyl adhesive material, and oxygen plasma treatment were employed to fabricate the device. Drug release rate was controlled by the micro-channel attached to the reservoir. Micro-channels with widths 300μm, 400μm, 500μm and depth 95μm were tested. Drug release is executed by deflecting the magnetic membrane outlet by an external electromagnetic field generating source: a permanent magnet or a planar copper coil.
AB - An implantable drug delivery device with an inflatable/deflatable reservoir, a release rate controlling micro-channel, a syringe attachable inlet, a unidirectional channel preventing drug substances from flowing back into the inlet, and a magnetic polydimethylsiloxane (PDMS) outlet capable of on-demand drug release was designed and fabricated to realize effective drug therapy. The reservoir is refillable through the inlet. Therefore, the device is reusable. The device does not employ photolithography patterning. Vapor coating, a precise cutting plotter, a vinyl adhesive material, and oxygen plasma treatment were employed to fabricate the device. Drug release rate was controlled by the micro-channel attached to the reservoir. Micro-channels with widths 300μm, 400μm, 500μm and depth 95μm were tested. Drug release is executed by deflecting the magnetic membrane outlet by an external electromagnetic field generating source: a permanent magnet or a planar copper coil.
UR - https://www.scopus.com/pages/publications/85032207034
U2 - 10.1109/EMBC.2017.8036822
DO - 10.1109/EMBC.2017.8036822
M3 - Conference contribution
C2 - 29059870
AN - SCOPUS:85032207034
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 300
EP - 303
BT - 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017
Y2 - 11 July 2017 through 15 July 2017
ER -