TY - JOUR
T1 - Perilla oil and α-linolenic acid ameliorated thrombosis in rats induced by collagen and epinephrine
AU - Kim, Jin Tae
AU - Lee, Seung Beom
AU - Son, Moon Jeong
AU - Zhou, Yimeng
AU - Qiu, Shuai
AU - Park, Ho Jin
AU - Jeon, Dong Hyeon
AU - Kim, Young Jun
AU - Lee, Hong Jin
N1 - Publisher Copyright:
© 2023, The Korean Society of Food Science and Technology.
PY - 2023/6
Y1 - 2023/6
N2 - Perilla frutescens is an annual herbaceous plant widely cultivated for oil production in China, Japan, and Korea. In this study, we investigated the effect of perilla oil (PO) on thrombosis induced by collagen and epinephrine (CE) in rats. The oral administration of PO significantly increased prothrombin time (PT) and activated partial thromboplastin time (aPTT) in the blood plasma and inhibited the expression of cells adhesion markers (CAMs) such as intercellular CAM-1 (ICAM-1), vascular CAM (VCAM-1), E-selectin and P-selectin in the aorta tissue. Furthermore, pulmonary occlusion induced by CE in rats was suppressed by PO. α-Linolenic acid (ALA) was quantified at 60.14 ± 2.50 g/100 g of PO, and its oral administration at the same concentration with that in PO exerted the similar effect on PT, aPTT, ICAM-1, VCAM-1, E-selectin and P-selectin in CE-induced thrombosis rats. Taken together, PO and ALA significantly ameliorated thrombosis by regulating CAMs.
AB - Perilla frutescens is an annual herbaceous plant widely cultivated for oil production in China, Japan, and Korea. In this study, we investigated the effect of perilla oil (PO) on thrombosis induced by collagen and epinephrine (CE) in rats. The oral administration of PO significantly increased prothrombin time (PT) and activated partial thromboplastin time (aPTT) in the blood plasma and inhibited the expression of cells adhesion markers (CAMs) such as intercellular CAM-1 (ICAM-1), vascular CAM (VCAM-1), E-selectin and P-selectin in the aorta tissue. Furthermore, pulmonary occlusion induced by CE in rats was suppressed by PO. α-Linolenic acid (ALA) was quantified at 60.14 ± 2.50 g/100 g of PO, and its oral administration at the same concentration with that in PO exerted the similar effect on PT, aPTT, ICAM-1, VCAM-1, E-selectin and P-selectin in CE-induced thrombosis rats. Taken together, PO and ALA significantly ameliorated thrombosis by regulating CAMs.
KW - Cells adhesion molecules
KW - Collagen and epinephrine
KW - Perilla oil
KW - Thrombosis
KW - α-Linolenic acid
UR - http://www.scopus.com/inward/record.url?scp=85146861461&partnerID=8YFLogxK
U2 - 10.1007/s10068-022-01241-6
DO - 10.1007/s10068-022-01241-6
M3 - Article
AN - SCOPUS:85146861461
SN - 1226-7708
VL - 32
SP - 997
EP - 1003
JO - Food Science and Biotechnology
JF - Food Science and Biotechnology
IS - 7
ER -