TY - GEN
T1 - Physicochemical and biological characterization of hyaluronic acid-poly(ethylene oxide) hydrogel
AU - Jo, Seongyeon
AU - Hwang, Yunjae
AU - Kim, Sumi
AU - Shin, Eunkyoung
AU - Noh, Insup
PY - 2011
Y1 - 2011
N2 - Hydrogel is a cross-linked, 3-D network of polymers absorbing and retaining large amount water. It has been employed as diverse forms in tissue engineering and cell therapy, including micro- or nano- particles, films and coatings. Hyaluronic acid (HA), consisting of disaccharide units of glucuronic acid and N-acetylglucosamine, is major components of synovial fluid and a biodegradable polysaccharide, which is degraded by hyaluronidases. A HA-based hydrogel was synthesized by employing HA and poly(ethylene oxide) (PEO) after chemical modification of HA. Its physicochemical characterization was evlautaed by observing behaviors of gelation, rheology, swelling and drug release. In vitro biocompatibility and cell cytoxicity of the HA-PEO hydrogel were also done. Their results showed excellent potential as a scaffold for tissue engineering.
AB - Hydrogel is a cross-linked, 3-D network of polymers absorbing and retaining large amount water. It has been employed as diverse forms in tissue engineering and cell therapy, including micro- or nano- particles, films and coatings. Hyaluronic acid (HA), consisting of disaccharide units of glucuronic acid and N-acetylglucosamine, is major components of synovial fluid and a biodegradable polysaccharide, which is degraded by hyaluronidases. A HA-based hydrogel was synthesized by employing HA and poly(ethylene oxide) (PEO) after chemical modification of HA. Its physicochemical characterization was evlautaed by observing behaviors of gelation, rheology, swelling and drug release. In vitro biocompatibility and cell cytoxicity of the HA-PEO hydrogel were also done. Their results showed excellent potential as a scaffold for tissue engineering.
UR - https://www.scopus.com/pages/publications/84860496807
U2 - 10.1109/NMDC.2011.6155370
DO - 10.1109/NMDC.2011.6155370
M3 - Conference contribution
AN - SCOPUS:84860496807
SN - 9781457721397
T3 - 2011 IEEE Nanotechnology Materials and Devices Conference, NMDC 2011
SP - 318
EP - 319
BT - 2011 IEEE Nanotechnology Materials and Devices Conference, NMDC 2011
T2 - 2011 IEEE Nanotechnology Materials and Devices Conference, NMDC 2011
Y2 - 18 October 2011 through 21 October 2011
ER -