Prediction of Drug Classes with a Deep Neural Network using Drug Targets and Chemical Structure Data

Jeonghee Jo, Hyun Soo Choi, Sungroh Yoon

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

6 Scopus citations

Abstract

Drugs are classified according to their biological and chemical reactions, and the systems that they target. Thus, an accurate and efficient prediction method for drug class discovery would reveal key properties of candidate drugs, significantly conserving time and resources in drug repositioning and design. Previous approaches, based on data mining or statistics, required complicated feature construction in advance. Knowing that deep learning can identifying patterns in high-dimensional datasets without elaborate feature selection or engineering, we constructed a model for predicting drug classes using deep neural networks - with biological and chemical structure data. Our proposed model outperforms previous learning-based methods in terms of prediction accuracy.

Original languageEnglish
Title of host publicationProceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019
EditorsIllhoi Yoo, Jinbo Bi, Xiaohua Tony Hu
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages664-667
Number of pages4
ISBN (Electronic)9781728118673
DOIs
StatePublished - Nov 2019
Event2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019 - San Diego, United States
Duration: 18 Nov 201921 Nov 2019

Publication series

NameProceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019

Conference

Conference2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019
Country/TerritoryUnited States
CitySan Diego
Period18/11/1921/11/19

Keywords

  • convolutional neural network (CNN)
  • deep learning
  • drug
  • prediction
  • recurrent neural network (RNN)

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