TY - JOUR
T1 - Preparation, characterization, and stability of lipid nanoparticles including unsaturated lipids
AU - Park, Yeseul
AU - Park, Jin Won
N1 - Publisher Copyright:
© 2023 the author(s), published by De Gruyter, Berlin/Boston.
PY - 2023/11
Y1 - 2023/11
N2 - Among the SARS-CoV-2 vaccines developed to date, the mRNA vaccines developed by the Pfizer/BioNTech and Moderna companies have been formulated using saturated lipids, specifically 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), along with cholesterol. DSPC and cholesterol have the disadvantage of causing sclerosis. Therefore, in this study, lipid nanoparticles (LNPs) were prepared and characterized by replacing DSPC with 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and excluding cholesterol. The results showed that the DOPC-based LNPs had a smaller diameter (75.67nm) compared to the previous study and the polydispersity index (PI) indicated a good dispersion homogeneity, suggesting size uniformity. Additionally, the LNPs maintained their size between 57nm and 152nm and showed stable PI values (0.330-0.393) throughout the 25 days.
AB - Among the SARS-CoV-2 vaccines developed to date, the mRNA vaccines developed by the Pfizer/BioNTech and Moderna companies have been formulated using saturated lipids, specifically 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), along with cholesterol. DSPC and cholesterol have the disadvantage of causing sclerosis. Therefore, in this study, lipid nanoparticles (LNPs) were prepared and characterized by replacing DSPC with 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and excluding cholesterol. The results showed that the DOPC-based LNPs had a smaller diameter (75.67nm) compared to the previous study and the polydispersity index (PI) indicated a good dispersion homogeneity, suggesting size uniformity. Additionally, the LNPs maintained their size between 57nm and 152nm and showed stable PI values (0.330-0.393) throughout the 25 days.
KW - atherosclerosis
KW - ethanol injection method
KW - lipid nanoparticle
KW - polydispersity index
KW - unsaturated lipid
UR - https://www.scopus.com/pages/publications/85172120129
U2 - 10.1515/tsd-2023-2544
DO - 10.1515/tsd-2023-2544
M3 - Article
AN - SCOPUS:85172120129
SN - 0932-3414
VL - 60
SP - 594
EP - 598
JO - Tenside, Surfactants, Detergents
JF - Tenside, Surfactants, Detergents
IS - 6
ER -
