Abstract
Among the SARS-CoV-2 vaccines developed to date, the mRNA vaccines developed by the Pfizer/BioNTech and Moderna companies have been formulated using saturated lipids, specifically 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), along with cholesterol. DSPC and cholesterol have the disadvantage of causing sclerosis. Therefore, in this study, lipid nanoparticles (LNPs) were prepared and characterized by replacing DSPC with 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and excluding cholesterol. The results showed that the DOPC-based LNPs had a smaller diameter (75.67nm) compared to the previous study and the polydispersity index (PI) indicated a good dispersion homogeneity, suggesting size uniformity. Additionally, the LNPs maintained their size between 57nm and 152nm and showed stable PI values (0.330-0.393) throughout the 25 days.
| Original language | English |
|---|---|
| Pages (from-to) | 594-598 |
| Number of pages | 5 |
| Journal | Tenside, Surfactants, Detergents |
| Volume | 60 |
| Issue number | 6 |
| DOIs | |
| State | Published - Nov 2023 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- atherosclerosis
- ethanol injection method
- lipid nanoparticle
- polydispersity index
- unsaturated lipid
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