Radioiodination and biodistribution of quantum dots using Bolton-Hunter reagent

Jae Jun Park; Tae Sup Lee; Joo Hyun Kang; Rita Song; Gi Jeong Cheon

doi:10.1016/j.apradiso.2010.09.004

Radioiodination and biodistribution of quantum dots using Bolton-Hunter reagent

Jae Jun Park
, Tae Sup Lee
, Joo Hyun Kang
, Rita Song
, Gi Jeong Cheon

Dept. of Biomedical Sciences

Korea Institute of Radiological and Medical Sciences
Institut Pasteur Korea

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

In this study, the radioiodination and biodistribution of quantum dots (QDs) using Bolton-Hunter reagent were investigated. Radioiodination yield was 33.4±2.0%. Fluorescent intensity of radioiodinated QDs decreased to 75.4% of the maximum prior to radioiodination. In biodistribution and ex vivo fluorescence imaging, radioiodinated QDs were highly accumulated in reticuloendothelial system (liver and spleen) and had low level bone uptakes and slow clearance from body. These results suggest that the radioiodination method of nanoparticles using Bolton-Hunter reagent could be easily used in the biodistribution and quantification of nanoparticles in vivo.

Original language	English
Pages (from-to)	56-62
Number of pages	7
Journal	Applied Radiation and Isotopes
Volume	69
Issue number	1
DOIs	https://doi.org/10.1016/j.apradiso.2010.09.004
State	Published - Jan 2011

Keywords

Biodistribution
Bolton-Hunter reagent
Fluorescence imaging
Quantum dot

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10.1016/j.apradiso.2010.09.004

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title = "Radioiodination and biodistribution of quantum dots using Bolton-Hunter reagent",

abstract = "In this study, the radioiodination and biodistribution of quantum dots (QDs) using Bolton-Hunter reagent were investigated. Radioiodination yield was 33.4±2.0\%. Fluorescent intensity of radioiodinated QDs decreased to 75.4\% of the maximum prior to radioiodination. In biodistribution and ex vivo fluorescence imaging, radioiodinated QDs were highly accumulated in reticuloendothelial system (liver and spleen) and had low level bone uptakes and slow clearance from body. These results suggest that the radioiodination method of nanoparticles using Bolton-Hunter reagent could be easily used in the biodistribution and quantification of nanoparticles in vivo.",

keywords = "Biodistribution, Bolton-Hunter reagent, Fluorescence imaging, Quantum dot",

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AU - Hyun Kang, Joo

AU - Song, Rita

AU - Jeong Cheon, Gi

PY - 2011/1

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N2 - In this study, the radioiodination and biodistribution of quantum dots (QDs) using Bolton-Hunter reagent were investigated. Radioiodination yield was 33.4±2.0%. Fluorescent intensity of radioiodinated QDs decreased to 75.4% of the maximum prior to radioiodination. In biodistribution and ex vivo fluorescence imaging, radioiodinated QDs were highly accumulated in reticuloendothelial system (liver and spleen) and had low level bone uptakes and slow clearance from body. These results suggest that the radioiodination method of nanoparticles using Bolton-Hunter reagent could be easily used in the biodistribution and quantification of nanoparticles in vivo.

AB - In this study, the radioiodination and biodistribution of quantum dots (QDs) using Bolton-Hunter reagent were investigated. Radioiodination yield was 33.4±2.0%. Fluorescent intensity of radioiodinated QDs decreased to 75.4% of the maximum prior to radioiodination. In biodistribution and ex vivo fluorescence imaging, radioiodinated QDs were highly accumulated in reticuloendothelial system (liver and spleen) and had low level bone uptakes and slow clearance from body. These results suggest that the radioiodination method of nanoparticles using Bolton-Hunter reagent could be easily used in the biodistribution and quantification of nanoparticles in vivo.

KW - Biodistribution

KW - Bolton-Hunter reagent

KW - Fluorescence imaging

KW - Quantum dot

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EP - 62

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

IS - 1

ER -

Radioiodination and biodistribution of quantum dots using Bolton-Hunter reagent

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Keywords

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