Rapid monitoring of sepsis by integration of spiral inertial microfluidics and isodielectric separation

Do Hyun Lee, Hyungkook Jeon, Bakr Jundi, Rebecca M. Baron, Bruce D. Levy, Jongyoon Han, Joel Voldman

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Here, we show the first clinical application of dielectrophoresis (DEP), specifically that electrical phenotyping correlates with clinical severity scores better than leukocyte counts (r = -0.23, not shown), and therefore holds promise for rapid label-free monitoring of sepsis progression. Further, we integrated isodielectric separation (IDS) device with a multi-dimensional double spiral (MDDS) inertial separation device to develop a fully-automated integrated platform for label-free and rapid measurement of polymorphonuclear neutrophils (PMN) from microliter quantities of human peripheral blood.

Original languageEnglish
Title of host publication23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
PublisherChemical and Biological Microsystems Society
Pages213-214
Number of pages2
ISBN (Electronic)9781733419000
StatePublished - 2019
Event23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, Switzerland
Duration: 27 Oct 201931 Oct 2019

Publication series

Name23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

Conference

Conference23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
Country/TerritorySwitzerland
CityBasel
Period27/10/1931/10/19

Keywords

  • Dielectrophoresis
  • Inertial microfluidics
  • Neutrophil activation
  • Sepsis

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