Ratiometric fluorescence In3+ sensing via In3+-triggered tautomerization: Its applications to water samples, live cells and zebrafish

Dongju Yun; Ju Byeong Chae; Haeri So; Trinh N. Do; Ki Tae Kim; Yelim Yi; Mi Hee Lim; Cheal Kim

doi:10.1016/j.dyepig.2020.108704

Ratiometric fluorescence In³⁺ sensing via In³⁺-triggered tautomerization: Its applications to water samples, live cells and zebrafish

Dongju Yun, Ju Byeong Chae, Haeri So, Trinh N. Do, Ki Tae Kim, Yelim Yi, Mi Hee Lim, Cheal Kim

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

A novel ratiometric fluorescence sensor NCS ((E)-N-(furan-2-ylmethyl)-2-(2-hydroxybenzylidene)hydrazine-1-carbothioamide) was synthesized by a combination of furfuryl isothiocyanate bearing hydrazine and salicylaldehyde. Sensor NCS exhibited a ratiometric fluorescent response toward In³⁺ via thioamide tautomerization with blue-shifted emission from 484 to 444 nm in a near-perfect aqueous solution. NCS displayed a linear ratiometric relationship to micromolar concentrations (0–60 μM) of In³⁺ and the detection limit was found to be 2.68 μM. Moreover, sensor NCS exhibited an excellent selectivity for sensing In³⁺ in real samples as well as live cell and zebrafish. The sensing mechanism was demonstrated through UV–visible, fluorescent and ¹H NMR titrations, Job's plot, ESI-MS and theoretical calculations.

Original language	English
Article number	108704
Journal	Dyes and Pigments
Volume	183
DOIs	https://doi.org/10.1016/j.dyepig.2020.108704
State	Published - Dec 2020

Keywords

Bioimaging
Calculations
Fluorescence chemosensor
Indium
Ratiometric
Tautomerization

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10.1016/j.dyepig.2020.108704

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@article{7b79a360c9db4114992c8324241a0100,

title = "Ratiometric fluorescence In3+ sensing via In3+-triggered tautomerization: Its applications to water samples, live cells and zebrafish",

abstract = "A novel ratiometric fluorescence sensor NCS ((E)-N-(furan-2-ylmethyl)-2-(2-hydroxybenzylidene)hydrazine-1-carbothioamide) was synthesized by a combination of furfuryl isothiocyanate bearing hydrazine and salicylaldehyde. Sensor NCS exhibited a ratiometric fluorescent response toward In3+ via thioamide tautomerization with blue-shifted emission from 484 to 444 nm in a near-perfect aqueous solution. NCS displayed a linear ratiometric relationship to micromolar concentrations (0–60 μM) of In3+ and the detection limit was found to be 2.68 μM. Moreover, sensor NCS exhibited an excellent selectivity for sensing In3+ in real samples as well as live cell and zebrafish. The sensing mechanism was demonstrated through UV–visible, fluorescent and 1H NMR titrations, Job's plot, ESI-MS and theoretical calculations.",

keywords = "Bioimaging, Calculations, Fluorescence chemosensor, Indium, Ratiometric, Tautomerization",

author = "Dongju Yun and Chae, \{Ju Byeong\} and Haeri So and Do, \{Trinh N.\} and Kim, \{Ki Tae\} and Yelim Yi and Lim, \{Mi Hee\} and Cheal Kim",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2020",

month = dec,

doi = "10.1016/j.dyepig.2020.108704",

language = "English",

volume = "183",

journal = "Dyes and Pigments",

issn = "0143-7208",

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T1 - Ratiometric fluorescence In3+ sensing via In3+-triggered tautomerization

T2 - Its applications to water samples, live cells and zebrafish

AU - Yun, Dongju

AU - Chae, Ju Byeong

AU - So, Haeri

AU - Do, Trinh N.

AU - Kim, Ki Tae

AU - Yi, Yelim

AU - Lim, Mi Hee

AU - Kim, Cheal

PY - 2020/12

Y1 - 2020/12

N2 - A novel ratiometric fluorescence sensor NCS ((E)-N-(furan-2-ylmethyl)-2-(2-hydroxybenzylidene)hydrazine-1-carbothioamide) was synthesized by a combination of furfuryl isothiocyanate bearing hydrazine and salicylaldehyde. Sensor NCS exhibited a ratiometric fluorescent response toward In3+ via thioamide tautomerization with blue-shifted emission from 484 to 444 nm in a near-perfect aqueous solution. NCS displayed a linear ratiometric relationship to micromolar concentrations (0–60 μM) of In3+ and the detection limit was found to be 2.68 μM. Moreover, sensor NCS exhibited an excellent selectivity for sensing In3+ in real samples as well as live cell and zebrafish. The sensing mechanism was demonstrated through UV–visible, fluorescent and 1H NMR titrations, Job's plot, ESI-MS and theoretical calculations.

AB - A novel ratiometric fluorescence sensor NCS ((E)-N-(furan-2-ylmethyl)-2-(2-hydroxybenzylidene)hydrazine-1-carbothioamide) was synthesized by a combination of furfuryl isothiocyanate bearing hydrazine and salicylaldehyde. Sensor NCS exhibited a ratiometric fluorescent response toward In3+ via thioamide tautomerization with blue-shifted emission from 484 to 444 nm in a near-perfect aqueous solution. NCS displayed a linear ratiometric relationship to micromolar concentrations (0–60 μM) of In3+ and the detection limit was found to be 2.68 μM. Moreover, sensor NCS exhibited an excellent selectivity for sensing In3+ in real samples as well as live cell and zebrafish. The sensing mechanism was demonstrated through UV–visible, fluorescent and 1H NMR titrations, Job's plot, ESI-MS and theoretical calculations.

KW - Bioimaging

KW - Calculations

KW - Fluorescence chemosensor

KW - Indium

KW - Ratiometric

KW - Tautomerization

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U2 - 10.1016/j.dyepig.2020.108704

DO - 10.1016/j.dyepig.2020.108704

M3 - Article

AN - SCOPUS:85089139370

SN - 0143-7208

VL - 183

JO - Dyes and Pigments

JF - Dyes and Pigments

M1 - 108704

ER -

Ratiometric fluorescence In³⁺ sensing via In³⁺-triggered tautomerization: Its applications to water samples, live cells and zebrafish

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Keywords

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