Sequential detection of mercury(II) and thiol-containing amino acids by a fluorescent chemosensor

Ga Rim You; Sun Young Lee; Jae Jun Lee; Yong Sung Kim; Cheal Kim

doi:10.1039/c5ra25138a

Sequential detection of mercury(II) and thiol-containing amino acids by a fluorescent chemosensor

Ga Rim You, Sun Young Lee, Jae Jun Lee, Yong Sung Kim, Cheal Kim

Dept. of Fine Chemistry

Seoul National University of Science and Technology (SNUST)

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

A simple fluorescent chemosensor 1 for the sequential detection of Hg²⁺ and cysteine or glutathione was developed by combination of thiosemicarbazide and 8-hydroxyjulolidine-9-carboxaldehyde. Sensor 1 exhibited an 'ON-OFF' fluorescence quenching response in the presence of Hg²⁺, which was explained by theoretical calculations. 1 also showed high selectivity in the presence of potential competitors such as Ag⁺ and Pb²⁺. Moreover, the resulting Hg²⁺-2·1 complex acted as an efficient 'OFF-ON' sensor for cysteine or glutathione, showing recovery of 2·1 from Hg²⁺-2·1 complex. Therefore, sensor 1 can be employed as a practical fluorescent chemosensor for recognition of Hg²⁺ and thiol-containing amino acids in aqueous solution.

Original language	English
Pages (from-to)	4212-4220
Number of pages	9
Journal	RSC Advances
Volume	6
Issue number	5
DOIs	https://doi.org/10.1039/c5ra25138a
State	Published - 2016

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title = "Sequential detection of mercury(II) and thiol-containing amino acids by a fluorescent chemosensor",

abstract = "A simple fluorescent chemosensor 1 for the sequential detection of Hg2+ and cysteine or glutathione was developed by combination of thiosemicarbazide and 8-hydroxyjulolidine-9-carboxaldehyde. Sensor 1 exhibited an 'ON-OFF' fluorescence quenching response in the presence of Hg2+, which was explained by theoretical calculations. 1 also showed high selectivity in the presence of potential competitors such as Ag+ and Pb2+. Moreover, the resulting Hg2+-2·1 complex acted as an efficient 'OFF-ON' sensor for cysteine or glutathione, showing recovery of 2·1 from Hg2+-2·1 complex. Therefore, sensor 1 can be employed as a practical fluorescent chemosensor for recognition of Hg2+ and thiol-containing amino acids in aqueous solution.",

author = "You, {Ga Rim} and Lee, {Sun Young} and Lee, {Jae Jun} and Kim, {Yong Sung} and Cheal Kim",

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AU - You, Ga Rim

AU - Lee, Sun Young

AU - Lee, Jae Jun

AU - Kim, Yong Sung

AU - Kim, Cheal

PY - 2016

Y1 - 2016

N2 - A simple fluorescent chemosensor 1 for the sequential detection of Hg2+ and cysteine or glutathione was developed by combination of thiosemicarbazide and 8-hydroxyjulolidine-9-carboxaldehyde. Sensor 1 exhibited an 'ON-OFF' fluorescence quenching response in the presence of Hg2+, which was explained by theoretical calculations. 1 also showed high selectivity in the presence of potential competitors such as Ag+ and Pb2+. Moreover, the resulting Hg2+-2·1 complex acted as an efficient 'OFF-ON' sensor for cysteine or glutathione, showing recovery of 2·1 from Hg2+-2·1 complex. Therefore, sensor 1 can be employed as a practical fluorescent chemosensor for recognition of Hg2+ and thiol-containing amino acids in aqueous solution.

AB - A simple fluorescent chemosensor 1 for the sequential detection of Hg2+ and cysteine or glutathione was developed by combination of thiosemicarbazide and 8-hydroxyjulolidine-9-carboxaldehyde. Sensor 1 exhibited an 'ON-OFF' fluorescence quenching response in the presence of Hg2+, which was explained by theoretical calculations. 1 also showed high selectivity in the presence of potential competitors such as Ag+ and Pb2+. Moreover, the resulting Hg2+-2·1 complex acted as an efficient 'OFF-ON' sensor for cysteine or glutathione, showing recovery of 2·1 from Hg2+-2·1 complex. Therefore, sensor 1 can be employed as a practical fluorescent chemosensor for recognition of Hg2+ and thiol-containing amino acids in aqueous solution.

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JO - RSC Advances

JF - RSC Advances

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Sequential detection of mercury(II) and thiol-containing amino acids by a fluorescent chemosensor

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