Simultaneous bioimaging recognition of cation Al3+ and anion F- by a fluorogenic method

Yong Sung Kim; Jae Jun Lee; Ye Won Choi; Ga Rim You; Le Tuyen Nguyen; Insup Noh; Cheal Kim

doi:10.1016/j.dyepig.2016.02.016

Simultaneous bioimaging recognition of cation Al³⁺ and anion F^- by a fluorogenic method

Yong Sung Kim, Jae Jun Lee, Ye Won Choi, Ga Rim You, Le Tuyen Nguyen, Insup Noh, Cheal Kim

Seoul National University of Science and Technology (SNUST)

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

A new highly selective and sensitive chemosensor 1 for both Al³⁺ and F^- was designed and synthesized. 1 could detect both Al³⁺ and F^- with turn-on fluorescence behavior in a nearly perfect aqueous solution. The binding stoichiometry of receptor 1 with Al³⁺ and F^- was proposed to be 1:1, respectively, based on Job plot, ¹H NMR titration and ESI-mass spectrometry analysis. The detection limits (1.12 μM for Al³⁺ and 7.01 μM for F^-) of 1 for Al³⁺ and F^- were lower than the World Health Organization guidelines (7.41 μM for Al³⁺ and 79 μM for F^-) for drinking water. Chemosensor 1 was also successfully applied to living cells for simultaneous detection and quantification of both Al³⁺ and F^-. Moreover, the sensing mechanisms of 1 toward Al³⁺ and F^- were explained by theoretical calculations.

Original language	English
Pages (from-to)	43-53
Number of pages	11
Journal	Dyes and Pigments
Volume	129
DOIs	https://doi.org/10.1016/j.dyepig.2016.02.016
State	Published - Jun 2016

Keywords

Aluminum ion
Cell imaging
Fluorescence
Fluoride
Julolidine
Theoretical calculations

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.dyepig.2016.02.016

Cite this

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title = "Simultaneous bioimaging recognition of cation Al3+ and anion F- by a fluorogenic method",

abstract = "A new highly selective and sensitive chemosensor 1 for both Al3+ and F- was designed and synthesized. 1 could detect both Al3+ and F- with turn-on fluorescence behavior in a nearly perfect aqueous solution. The binding stoichiometry of receptor 1 with Al3+ and F- was proposed to be 1:1, respectively, based on Job plot, 1H NMR titration and ESI-mass spectrometry analysis. The detection limits (1.12 μM for Al3+ and 7.01 μM for F-) of 1 for Al3+ and F- were lower than the World Health Organization guidelines (7.41 μM for Al3+ and 79 μM for F-) for drinking water. Chemosensor 1 was also successfully applied to living cells for simultaneous detection and quantification of both Al3+ and F-. Moreover, the sensing mechanisms of 1 toward Al3+ and F- were explained by theoretical calculations.",

keywords = "Aluminum ion, Cell imaging, Fluorescence, Fluoride, Julolidine, Theoretical calculations",

author = "Kim, \{Yong Sung\} and Lee, \{Jae Jun\} and Choi, \{Ye Won\} and You, \{Ga Rim\} and Nguyen, \{Le Tuyen\} and Insup Noh and Cheal Kim",

year = "2016",

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doi = "10.1016/j.dyepig.2016.02.016",

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AU - Kim, Yong Sung

AU - Lee, Jae Jun

AU - Choi, Ye Won

AU - You, Ga Rim

AU - Nguyen, Le Tuyen

AU - Noh, Insup

AU - Kim, Cheal

PY - 2016/6

Y1 - 2016/6

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AB - A new highly selective and sensitive chemosensor 1 for both Al3+ and F- was designed and synthesized. 1 could detect both Al3+ and F- with turn-on fluorescence behavior in a nearly perfect aqueous solution. The binding stoichiometry of receptor 1 with Al3+ and F- was proposed to be 1:1, respectively, based on Job plot, 1H NMR titration and ESI-mass spectrometry analysis. The detection limits (1.12 μM for Al3+ and 7.01 μM for F-) of 1 for Al3+ and F- were lower than the World Health Organization guidelines (7.41 μM for Al3+ and 79 μM for F-) for drinking water. Chemosensor 1 was also successfully applied to living cells for simultaneous detection and quantification of both Al3+ and F-. Moreover, the sensing mechanisms of 1 toward Al3+ and F- were explained by theoretical calculations.

KW - Aluminum ion

KW - Cell imaging

KW - Fluorescence

KW - Fluoride

KW - Julolidine

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