Synthesis and evaluation of hyaluronic acid-poly(ethylene oxide) hydrogel via Michael-type addition reaction

Gun Woo Kim; Yoon Jeong Choi; Mi Sook Kim; Yongdoo Park; Kyu Back Lee; In Sook Kim; Soon Jung Hwang; Insup Noh

doi:10.1016/j.cap.2006.11.009

Synthesis and evaluation of hyaluronic acid-poly(ethylene oxide) hydrogel via Michael-type addition reaction

Gun Woo Kim
, Yoon Jeong Choi
, Mi Sook Kim
, Yongdoo Park
, Kyu Back Lee
, In Sook Kim
, Soon Jung Hwang
, Insup Noh

Dept. of Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Hyaluronic acid-based hydrogel was synthesized by reacting hyaluronic acid with aminopropyl methacrylate and then with poly(ethylene oxide). Gelation was observed within 5.5 h with a rheometer by employing viscous and elastic modulus. While the hydrogel was analyzed by light and electron microscopy for morphological observation, other analysis was performed by Fourier-transformed infrared and electron spectroscopy for chemical analysis. Understanding of a putative reaction scheme was outlined by reference to N-(3-diethylpropyl)-N-ethylcarbodiimide hydrochloride for acrylation of hyaluronic acid and by a Michael-type reaction between methacrylate in aminopropyl methacrylate and thiol arms in PEO end groups.

Original language	English
Pages (from-to)	e28-e32
Journal	Current Applied Physics
Volume	7
Issue number	SUPPL.1
DOIs	https://doi.org/10.1016/j.cap.2006.11.009
State	Published - Apr 2007

Keywords

Evaluation
Hyaluronic acid
In situ hydrogel
Poly(ethylene oxide)

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10.1016/j.cap.2006.11.009

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title = "Synthesis and evaluation of hyaluronic acid-poly(ethylene oxide) hydrogel via Michael-type addition reaction",

abstract = "Hyaluronic acid-based hydrogel was synthesized by reacting hyaluronic acid with aminopropyl methacrylate and then with poly(ethylene oxide). Gelation was observed within 5.5 h with a rheometer by employing viscous and elastic modulus. While the hydrogel was analyzed by light and electron microscopy for morphological observation, other analysis was performed by Fourier-transformed infrared and electron spectroscopy for chemical analysis. Understanding of a putative reaction scheme was outlined by reference to N-(3-diethylpropyl)-N-ethylcarbodiimide hydrochloride for acrylation of hyaluronic acid and by a Michael-type reaction between methacrylate in aminopropyl methacrylate and thiol arms in PEO end groups.",

keywords = "Evaluation, Hyaluronic acid, In situ hydrogel, Poly(ethylene oxide)",

author = "Kim, \{Gun Woo\} and Choi, \{Yoon Jeong\} and Kim, \{Mi Sook\} and Yongdoo Park and Lee, \{Kyu Back\} and Kim, \{In Sook\} and Hwang, \{Soon Jung\} and Insup Noh",

year = "2007",

month = apr,

doi = "10.1016/j.cap.2006.11.009",

language = "English",

volume = "7",

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journal = "Current Applied Physics",

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TY - JOUR

T1 - Synthesis and evaluation of hyaluronic acid-poly(ethylene oxide) hydrogel via Michael-type addition reaction

AU - Kim, Gun Woo

AU - Choi, Yoon Jeong

AU - Kim, Mi Sook

AU - Park, Yongdoo

AU - Lee, Kyu Back

AU - Kim, In Sook

AU - Hwang, Soon Jung

AU - Noh, Insup

PY - 2007/4

Y1 - 2007/4

N2 - Hyaluronic acid-based hydrogel was synthesized by reacting hyaluronic acid with aminopropyl methacrylate and then with poly(ethylene oxide). Gelation was observed within 5.5 h with a rheometer by employing viscous and elastic modulus. While the hydrogel was analyzed by light and electron microscopy for morphological observation, other analysis was performed by Fourier-transformed infrared and electron spectroscopy for chemical analysis. Understanding of a putative reaction scheme was outlined by reference to N-(3-diethylpropyl)-N-ethylcarbodiimide hydrochloride for acrylation of hyaluronic acid and by a Michael-type reaction between methacrylate in aminopropyl methacrylate and thiol arms in PEO end groups.

AB - Hyaluronic acid-based hydrogel was synthesized by reacting hyaluronic acid with aminopropyl methacrylate and then with poly(ethylene oxide). Gelation was observed within 5.5 h with a rheometer by employing viscous and elastic modulus. While the hydrogel was analyzed by light and electron microscopy for morphological observation, other analysis was performed by Fourier-transformed infrared and electron spectroscopy for chemical analysis. Understanding of a putative reaction scheme was outlined by reference to N-(3-diethylpropyl)-N-ethylcarbodiimide hydrochloride for acrylation of hyaluronic acid and by a Michael-type reaction between methacrylate in aminopropyl methacrylate and thiol arms in PEO end groups.

KW - Evaluation

KW - Hyaluronic acid

KW - In situ hydrogel

KW - Poly(ethylene oxide)

UR - https://www.scopus.com/pages/publications/33847159143

U2 - 10.1016/j.cap.2006.11.009

DO - 10.1016/j.cap.2006.11.009

M3 - Article

AN - SCOPUS:33847159143

SN - 1567-1739

VL - 7

SP - e28-e32

JO - Current Applied Physics

JF - Current Applied Physics

IS - SUPPL.1

ER -

Synthesis and evaluation of hyaluronic acid-poly(ethylene oxide) hydrogel via Michael-type addition reaction

Abstract

Keywords

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